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- W2122808130 abstract "A 64-year old man who presented with stress angina, carotid atheromatous plaques and high blood pressure was admitted to undergo coronary angiography whose results were grossly normal (Fig. 1) including right and left hemodynamic data. The patient was detected 6 months later with laryngeal carcinoma and he underwent radiotherapy. During 3 successive months he was exposed to 5040 centi-Gray units (cGy) plus a boost dose of 1980 cGy. The overall exposure, also taking the previous coronarographic session (15 sequences totaling 208.6 cGy) into account, was therefore 7228.6 cGy. The patient was also treated by cycles of cisplatin and 5-fluorouracil. He had to stop the second chemotherapeutical cycle because of typical angina, marked bradycardia and widespread abnormalities of ventricular repolarization. He was then referred for a second coronary angiography. Significant stenoses were shown at the ostial level of both left anterior and circumflex coronary arteries (Fig. 2A). A kissing–stenting technique was performed with excellent angiographic results (Fig. 2B). Radiation exposure may induce, especially in the young, ostial coronary lesions [1]. Radiationsmay affect the heart to induce from subclinical histopathological changes to overt clinical diseases including coronary artery disease, pericarditis, conduction abnormalities and valvular injuries [2,3]. The risk is higher when the mediastinal doses exceed 30 Gy [4] and it seems related to irradiated tissue volume and fraction size [5]. Cancer and atherosclerosis share the same stages of initiation, promotion and complication beginning in a single cell mutation, whereas cytokines and growth factors are involved in the atherosclerotic process [6]. Radiation" @default.
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- W2122808130 date "2012-08-01" @default.
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- W2122808130 title "Ostial coronary stenoses after radiation therapy" @default.
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- W2122808130 doi "https://doi.org/10.1016/j.ijcard.2011.10.123" @default.
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