FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122811559> ?p ?o ?g. }

• W2122811559 endingPage "4091" @default.
• W2122811559 startingPage "4082" @default.
• W2122811559 abstract "Context: Whereas insulin resistance and obesity coexist, some obese individuals remain insulin sensitive. Objective: We examined phenotypic and metabolic factors associated with insulin sensitivity in both muscle and liver in obese individuals. Design and Participants: Sixty-four nondiabetic obese adults (29 males) underwent hyperinsulinemic (15 and 80 mU/m2 · min)-euglycemic clamps with deuterated glucose. Top tertile subjects for glucose infusion rate during the high-dose insulin clamp were assigned Musclesen and those in the lower two tertiles were assigned Muscleres. Secondarily, top tertile subjects for endogenous glucose production suppression during the low-dose insulin clamp were deemed Liversen and the remainder Liverres. Main Outcomes Measures: Clinical and laboratory parameters and visceral, subcutaneous, liver, and pancreatic fat were compared. Results: Musclesen and Muscleres had similar body mass index and total fat (P &gt; .16), but Musclesen had lower glycated hemoglobin (P &lt; .001) and systolic (P = .01) and diastolic (P = .03) blood pressure (BP). Despite similar sc fat (P = 1), Musclesen had lower visceral (P &lt; .001) and liver (P &lt; .001) fat. Liversen had lower visceral (P &lt; .01) and liver (P &lt; .01) fat and C-reactive protein (P = .02) than Liverres. When subjects were grouped by both glucose infusion rate during the high-dose insulin clamp and endogenous glucose production suppression, insulin sensitivity at either muscle or liver conferred apparent protection from the adverse metabolic features that characterized subjects insulin resistant at both sites. High-density lipoprotein-cholesterol, 1-hour glucose, systolic BP, and triglycerides explained 54% of the variance in muscle insulin sensitivity. Conclusions: Obese subjects who were insulin sensitive at muscle and/or liver exhibited favorable metabolic features, including lower BP, liver and visceral adiposity. This study identifies factors associated with, and possibly contributing to, insulin sensitivity in obesity." @default.
• W2122811559 created "2016-06-24" @default.
• W2122811559 creator A5001212969 @default.
• W2122811559 creator A5006496319 @default.
• W2122811559 creator A5016988315 @default.
• W2122811559 creator A5019114599 @default.
• W2122811559 creator A5027877296 @default.
• W2122811559 creator A5031014820 @default.
• W2122811559 creator A5036796175 @default.
• W2122811559 creator A5052330951 @default.
• W2122811559 creator A5060261534 @default.
• W2122811559 creator A5072810264 @default.
• W2122811559 creator A5074403803 @default.
• W2122811559 creator A5079248131 @default.
• W2122811559 date "2015-11-01" @default.
• W2122811559 modified "2023-10-14" @default.
• W2122811559 title "Phenotypic Characterization of Insulin-Resistant and Insulin-Sensitive Obesity" @default.
• W2122811559 cites W1572399582 @default.
• W2122811559 cites W1935184657 @default.
• W2122811559 cites W1984182813 @default.
• W2122811559 cites W1986834207 @default.
• W2122811559 cites W1988918826 @default.
• W2122811559 cites W1989674525 @default.
• W2122811559 cites W1995268681 @default.
• W2122811559 cites W2006433855 @default.
• W2122811559 cites W2017342841 @default.
• W2122811559 cites W2018355423 @default.
• W2122811559 cites W2031736232 @default.
• W2122811559 cites W2033014138 @default.
• W2122811559 cites W2040945658 @default.
• W2122811559 cites W2044760021 @default.
• W2122811559 cites W2051772622 @default.
• W2122811559 cites W2054100836 @default.
• W2122811559 cites W2054963090 @default.
• W2122811559 cites W2055801125 @default.
• W2122811559 cites W2060115948 @default.
• W2122811559 cites W2071867050 @default.
• W2122811559 cites W2073584727 @default.
• W2122811559 cites W2077963393 @default.
• W2122811559 cites W2078849404 @default.
• W2122811559 cites W2084588743 @default.
• W2122811559 cites W2114647414 @default.
• W2122811559 cites W2115195372 @default.
• W2122811559 cites W2117434275 @default.
• W2122811559 cites W2122271489 @default.
• W2122811559 cites W2131525837 @default.
• W2122811559 cites W2133374684 @default.
• W2122811559 cites W2133795831 @default.
• W2122811559 cites W2135666165 @default.
• W2122811559 cites W2137890984 @default.
• W2122811559 cites W2146877877 @default.
• W2122811559 cites W2164122881 @default.
• W2122811559 cites W2168445785 @default.
• W2122811559 cites W2196957880 @default.
• W2122811559 cites W2329566104 @default.
• W2122811559 cites W2510708214 @default.
• W2122811559 doi "https://doi.org/10.1210/jc.2015-2712" @default.
• W2122811559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26378474" @default.
• W2122811559 hasPublicationYear "2015" @default.
• W2122811559 type Work @default.
• W2122811559 sameAs 2122811559 @default.
• W2122811559 citedByCount "54" @default.
• W2122811559 countsByYear W21228115592016 @default.
• W2122811559 countsByYear W21228115592017 @default.
• W2122811559 countsByYear W21228115592018 @default.
• W2122811559 countsByYear W21228115592019 @default.
• W2122811559 countsByYear W21228115592020 @default.
• W2122811559 countsByYear W21228115592021 @default.
• W2122811559 countsByYear W21228115592022 @default.
• W2122811559 countsByYear W21228115592023 @default.
• W2122811559 crossrefType "journal-article" @default.
• W2122811559 hasAuthorship W2122811559A5001212969 @default.
• W2122811559 hasAuthorship W2122811559A5006496319 @default.
• W2122811559 hasAuthorship W2122811559A5016988315 @default.
• W2122811559 hasAuthorship W2122811559A5019114599 @default.
• W2122811559 hasAuthorship W2122811559A5027877296 @default.
• W2122811559 hasAuthorship W2122811559A5031014820 @default.
• W2122811559 hasAuthorship W2122811559A5036796175 @default.
• W2122811559 hasAuthorship W2122811559A5052330951 @default.
• W2122811559 hasAuthorship W2122811559A5060261534 @default.
• W2122811559 hasAuthorship W2122811559A5072810264 @default.
• W2122811559 hasAuthorship W2122811559A5074403803 @default.
• W2122811559 hasAuthorship W2122811559A5079248131 @default.
• W2122811559 hasBestOaLocation W21228115591 @default.
• W2122811559 hasConcept C126322002 @default.
• W2122811559 hasConcept C134018914 @default.
• W2122811559 hasConcept C151730666 @default.
• W2122811559 hasConcept C2777180221 @default.
• W2122811559 hasConcept C2777391703 @default.
• W2122811559 hasConcept C2777538456 @default.
• W2122811559 hasConcept C2777866211 @default.
• W2122811559 hasConcept C2778808658 @default.
• W2122811559 hasConcept C2779306644 @default.
• W2122811559 hasConcept C2779343474 @default.
• W2122811559 hasConcept C2780352109 @default.
• W2122811559 hasConcept C511355011 @default.
• W2122811559 hasConcept C555293320 @default.
• W2122811559 hasConcept C71924100 @default.

• next