Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122827512> ?p ?o ?g. }
- W2122827512 endingPage "255" @default.
- W2122827512 startingPage "247" @default.
- W2122827512 abstract "Transmissible spongiform encephalopathies (TSEs) are characterized by the accumulation of a proteaseresistant abnormal isoform of the prion protein (PrPSc), which is converted from the cellular isoform of the prion protein (PrPC). In the oral transmission of prion protein, PrPSc can invade a host body through the intestinal tract. There is only limited information available on how the infectious agent passes through one or several biological barriers before it can finally reach the brain. After oral administration, PrPSc withstands the digestive process and may be incorporated by microfold (M) cells or villous columnar epithelial cells in the intestine. After entry into the intestinal epithelium, PrPSc accumulates and is amplified in follicular dendritic cells (FDCs) within Peyers patches and other isolated lymphoid follicles possibly by an interaction with dendritic cells or macrophages. Following accumulation in gut-associated lymphoid tissues, PrPSc is thought to move to the enteric nervous systems (ENS) by an interaction with FDCs or dendritic cells. As a result of neuroinvasion into the ENS, PrPSc spreads to the central nervous system. In addition, an epidemiological study suggested that most bovine spongiform encephalopathy cases had been exposed to the agent in the first 6 months of life. Developments of the intestinal defense and immune system may be involved in the susceptibility to infection. Keywords: GALT, intestinal epithelium, M cells, peripheral nervous system, prion protein" @default.
- W2122827512 created "2016-06-24" @default.
- W2122827512 creator A5016398425 @default.
- W2122827512 creator A5026563833 @default.
- W2122827512 creator A5056712491 @default.
- W2122827512 creator A5086535576 @default.
- W2122827512 date "2009-03-01" @default.
- W2122827512 modified "2023-10-17" @default.
- W2122827512 title "Uptake and Dynamics of Infectious Prion Protein in the Intestine" @default.
- W2122827512 cites W1483340343 @default.
- W2122827512 cites W15007214 @default.
- W2122827512 cites W1502117212 @default.
- W2122827512 cites W1504399240 @default.
- W2122827512 cites W1523600076 @default.
- W2122827512 cites W1528983532 @default.
- W2122827512 cites W1540278447 @default.
- W2122827512 cites W1541148800 @default.
- W2122827512 cites W1550397805 @default.
- W2122827512 cites W1551003041 @default.
- W2122827512 cites W1557415728 @default.
- W2122827512 cites W1567308366 @default.
- W2122827512 cites W1578176285 @default.
- W2122827512 cites W1610246685 @default.
- W2122827512 cites W1645442091 @default.
- W2122827512 cites W1829344915 @default.
- W2122827512 cites W1912744811 @default.
- W2122827512 cites W1964670668 @default.
- W2122827512 cites W1964712424 @default.
- W2122827512 cites W1966745534 @default.
- W2122827512 cites W1970266867 @default.
- W2122827512 cites W1970914909 @default.
- W2122827512 cites W1972644169 @default.
- W2122827512 cites W1978367617 @default.
- W2122827512 cites W1979554990 @default.
- W2122827512 cites W1983293478 @default.
- W2122827512 cites W1984335567 @default.
- W2122827512 cites W1985273834 @default.
- W2122827512 cites W1990496336 @default.
- W2122827512 cites W1991656595 @default.
- W2122827512 cites W1996051740 @default.
- W2122827512 cites W1998358216 @default.
- W2122827512 cites W1998648004 @default.
- W2122827512 cites W2003111539 @default.
- W2122827512 cites W2005566671 @default.
- W2122827512 cites W2013679718 @default.
- W2122827512 cites W2013696290 @default.
- W2122827512 cites W2016165466 @default.
- W2122827512 cites W2018290520 @default.
- W2122827512 cites W2020830047 @default.
- W2122827512 cites W2023486022 @default.
- W2122827512 cites W2023597018 @default.
- W2122827512 cites W2024965367 @default.
- W2122827512 cites W2028877565 @default.
- W2122827512 cites W2032735666 @default.
- W2122827512 cites W2037800837 @default.
- W2122827512 cites W2041844695 @default.
- W2122827512 cites W2043565278 @default.
- W2122827512 cites W2046511935 @default.
- W2122827512 cites W2048472782 @default.
- W2122827512 cites W2060087062 @default.
- W2122827512 cites W2063694409 @default.
- W2122827512 cites W2071711923 @default.
- W2122827512 cites W2074933353 @default.
- W2122827512 cites W2077118428 @default.
- W2122827512 cites W2082573664 @default.
- W2122827512 cites W2086169382 @default.
- W2122827512 cites W2090202861 @default.
- W2122827512 cites W2090900358 @default.
- W2122827512 cites W2094279987 @default.
- W2122827512 cites W2094521427 @default.
- W2122827512 cites W2099763646 @default.
- W2122827512 cites W2102731671 @default.
- W2122827512 cites W2104705629 @default.
- W2122827512 cites W2106922949 @default.
- W2122827512 cites W2111896347 @default.
- W2122827512 cites W2113193658 @default.
- W2122827512 cites W2116827456 @default.
- W2122827512 cites W2119749560 @default.
- W2122827512 cites W2120130639 @default.
- W2122827512 cites W2120568334 @default.
- W2122827512 cites W2121574465 @default.
- W2122827512 cites W2124577407 @default.
- W2122827512 cites W2127125043 @default.
- W2122827512 cites W2131820270 @default.
- W2122827512 cites W2136406145 @default.
- W2122827512 cites W2136563180 @default.
- W2122827512 cites W2141119255 @default.
- W2122827512 cites W2144104265 @default.
- W2122827512 cites W2150497169 @default.
- W2122827512 cites W2152074543 @default.
- W2122827512 cites W2155463696 @default.
- W2122827512 cites W2155817841 @default.
- W2122827512 cites W2158058793 @default.
- W2122827512 cites W2160322119 @default.
- W2122827512 cites W2161961129 @default.
- W2122827512 cites W2163455306 @default.
- W2122827512 cites W2164738818 @default.
- W2122827512 cites W2165062718 @default.