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- W2122874855 endingPage "3661" @default.
- W2122874855 startingPage "3646" @default.
- W2122874855 abstract "The endothelium is a cellular monolayer that lines the inner surface of blood vessels and plays a central role in the maintenance of cardiovascular homeostasis by controlling platelet aggregation, vascular tone, blood fluidity and fibrinolysis, adhesion and transmigration of inflammatory cells, and angiogenesis. Endothelial dysfunctions are associated with various cardiovascular diseases, including atherosclerosis, hypertension, myocardial infarction, and cardiovascular complications of diabetes. Numerous studies have established the anti-inflammatory, anti-apoptotic, and anti-oxidant effects of hydrogen sulfide (H2S), the latest member to join the gasotransmitter family along with nitric oxide and carbon monoxide, on vascular endothelium. In addition, H2S may prime endothelial cells (ECs) toward angiogenesis and contribute to wound healing, besides to its well-known ability to relax vascular smooth muscle cells (VSMCs), and thereby reducing blood pressure. Finally, H2S may inhibit VSMC proliferation and platelet aggregation. Consistently, a deficit in H2S homeostasis is involved in the pathogenesis of atherosclerosis and of hyperglycaemic endothelial injury. Therefore, the application of H2S-releasing drugs or using gene therapy to increase endogenous H2S level may help restore endothelial function and antagonize the progression of cardiovascular diseases. The present article reviews recent studies on the role of H2S in endothelial homeostasis, under both physiological and pathological conditions, and its putative therapeutic applications. Keywords: Angiogenesis, Endothelial dysfunction, Endothelium, Gasotransmitters, Hydrogen sulfide, Nitric oxide, Snitrosylation, S-sulfhydration." @default.
- W2122874855 created "2016-06-24" @default.
- W2122874855 creator A5010445895 @default.
- W2122874855 creator A5021553062 @default.
- W2122874855 creator A5026120374 @default.
- W2122874855 creator A5043861758 @default.
- W2122874855 creator A5059836069 @default.
- W2122874855 date "2014-07-06" @default.
- W2122874855 modified "2023-10-16" @default.
- W2122874855 title "Hydrogen Sulfide and Endothelial Dysfunction: Relationship with Nitric Oxide" @default.
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