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• W2122893105 abstract "The role of host and environmental factors in the pathogenesis of multiple melanocytic nevi, atypical nevi, and freckles was studied in 1989 in a random sample of 3,040 Israeli males aged 17 years. Multiple melanocytic nevi were significantly associated with family history of melanoma or multiple melanocytic nevi (odds ratio (OR)=15.0), fair or lightly pigmented skin color (OR=2.7 and 2.3, respectively), and affiliation to the high or heterogenous melanoma risk group, determined by the incidence rates of melanoma in Jewish migrants from corresponding origin (OR=3.1 and 2.1, respectively). An environment-related effect may account for the increased multiple melanocytic nevi risk among second- (OR=8.2) compared with first-generation, native-born recruits (OR=3.0) from the high melanoma risk group whose families had been living in Israel the longest. Atypical nevi were associated with fair (OR=6.1) and lightly pigmented (OR=3.5) skin color, high and moderate sunburn susceptibility (OR=4.7 and 2.5, respectively), and family history of melanoma or multiple melanocytic nevi (OR=4.7) Freckles were significantly associated with sun-sensitive phenotype, family history of melanoma or multiple melanocytic nevi (OR=1.5), Conservative (OR=1.9) or nonreligious status (OR=1.9), and high (OR=2.4) or heterogenous melanoma risk groups (OR=1.8). These findings indicate that environmental factors may modify the occurrence of multiple melanocytic nevi and freckles in genetically susceptible ethnic groups. Am J Epidemiol 1997;146:78–86." @default.
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• W2122893105 date "1997-07-01" @default.
• W2122893105 modified "2023-10-17" @default.
• W2122893105 title "Prevalence of Melanocytic Nevi and Freckles in Young Israeli Males: Correlation with Melanoma Incidence in Jewish Migrants: Demographic and Host Factors" @default.
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• W2122893105 doi "https://doi.org/10.1093/oxfordjournals.aje.a009193" @default.
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