Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122913401> ?p ?o ?g. }
- W2122913401 endingPage "5458" @default.
- W2122913401 startingPage "5447" @default.
- W2122913401 abstract "Id proteins are known to play important roles in the proliferation and differentiation of many cell types. The type 1 insulin-like growth factor receptor (IGF-IR), activated by its ligand, induces the differentiation of 32D IGF-IR cells, a murine hematopoietic cell line, expressing a human IGF-IR. Expression in 32D IGF-IR cells of a dominant negative mutant of Stat3 (DNStat3) inhibits IGF-I-mediated differentiation. DNStat3 causes a dramatic increase in Id2 gene expression. This increase, however, is IGF-I dependent and is abrogated by a mutation at tyrosine 950 of the IGF-IR. These results indicate that in 32D cells, the IGF-IR regulates the expression of the Id2 gene and that this regulation is modulated by both positive and negative signals. Our results also suggest that in this model, Id2 proteins influence the differentiation program of cells but are not sufficient for the full stimulation of their proliferation program." @default.
- W2122913401 created "2016-06-24" @default.
- W2122913401 creator A5016172056 @default.
- W2122913401 creator A5039304271 @default.
- W2122913401 creator A5050473672 @default.
- W2122913401 creator A5087771423 @default.
- W2122913401 date "2001-08-01" @default.
- W2122913401 modified "2023-10-10" @default.
- W2122913401 title "Regulation of Id Gene Expression by Type I Insulin-Like Growth Factor: Roles of STAT3 and the Tyrosine 950 Residue of the Receptor" @default.
- W2122913401 cites W105270160 @default.
- W2122913401 cites W13141722 @default.
- W2122913401 cites W1491356095 @default.
- W2122913401 cites W1496109170 @default.
- W2122913401 cites W1505072532 @default.
- W2122913401 cites W1523684384 @default.
- W2122913401 cites W1532583795 @default.
- W2122913401 cites W1550156431 @default.
- W2122913401 cites W1585751449 @default.
- W2122913401 cites W1622668755 @default.
- W2122913401 cites W1669954301 @default.
- W2122913401 cites W1782837552 @default.
- W2122913401 cites W1963723155 @default.
- W2122913401 cites W1967888146 @default.
- W2122913401 cites W1976259288 @default.
- W2122913401 cites W1982725837 @default.
- W2122913401 cites W1983165764 @default.
- W2122913401 cites W199729741 @default.
- W2122913401 cites W2001337617 @default.
- W2122913401 cites W2002014825 @default.
- W2122913401 cites W2002052645 @default.
- W2122913401 cites W2007217993 @default.
- W2122913401 cites W2008532096 @default.
- W2122913401 cites W2017237635 @default.
- W2122913401 cites W2026526170 @default.
- W2122913401 cites W2026577261 @default.
- W2122913401 cites W2026629561 @default.
- W2122913401 cites W2033726443 @default.
- W2122913401 cites W2041653037 @default.
- W2122913401 cites W2042218061 @default.
- W2122913401 cites W2046184981 @default.
- W2122913401 cites W2048121649 @default.
- W2122913401 cites W2051393939 @default.
- W2122913401 cites W2053383702 @default.
- W2122913401 cites W2055640859 @default.
- W2122913401 cites W2057216898 @default.
- W2122913401 cites W2063361476 @default.
- W2122913401 cites W2066647113 @default.
- W2122913401 cites W2079263525 @default.
- W2122913401 cites W2079392615 @default.
- W2122913401 cites W2081742266 @default.
- W2122913401 cites W2088894802 @default.
- W2122913401 cites W2090289340 @default.
- W2122913401 cites W2097645314 @default.
- W2122913401 cites W2099000660 @default.
- W2122913401 cites W2102369096 @default.
- W2122913401 cites W2102847486 @default.
- W2122913401 cites W2109577274 @default.
- W2122913401 cites W2109663412 @default.
- W2122913401 cites W2115186999 @default.
- W2122913401 cites W2116189789 @default.
- W2122913401 cites W2120662932 @default.
- W2122913401 cites W2121079321 @default.
- W2122913401 cites W2127945858 @default.
- W2122913401 cites W2132893561 @default.
- W2122913401 cites W2135913015 @default.
- W2122913401 cites W2139381527 @default.
- W2122913401 cites W2140793658 @default.
- W2122913401 cites W2144264604 @default.
- W2122913401 cites W2144447876 @default.
- W2122913401 cites W2159511823 @default.
- W2122913401 cites W2160770127 @default.
- W2122913401 cites W2168158551 @default.
- W2122913401 cites W2312447867 @default.
- W2122913401 cites W2313319084 @default.
- W2122913401 cites W2402392811 @default.
- W2122913401 cites W2430072599 @default.
- W2122913401 cites W3203413 @default.
- W2122913401 cites W4244341972 @default.
- W2122913401 cites W4253418569 @default.
- W2122913401 doi "https://doi.org/10.1128/mcb.21.16.5447-5458.2001" @default.
- W2122913401 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/87267" @default.
- W2122913401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11463827" @default.
- W2122913401 hasPublicationYear "2001" @default.
- W2122913401 type Work @default.
- W2122913401 sameAs 2122913401 @default.
- W2122913401 citedByCount "31" @default.
- W2122913401 countsByYear W21229134012012 @default.
- W2122913401 countsByYear W21229134012020 @default.
- W2122913401 crossrefType "journal-article" @default.
- W2122913401 hasAuthorship W2122913401A5016172056 @default.
- W2122913401 hasAuthorship W2122913401A5039304271 @default.
- W2122913401 hasAuthorship W2122913401A5050473672 @default.
- W2122913401 hasAuthorship W2122913401A5087771423 @default.
- W2122913401 hasBestOaLocation W21229134011 @default.
- W2122913401 hasConcept C104317684 @default.
- W2122913401 hasConcept C143065580 @default.
- W2122913401 hasConcept C148738053 @default.
- W2122913401 hasConcept C150194340 @default.