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- W2122914162 endingPage "R31" @default.
- W2122914162 startingPage "R31" @default.
- W2122914162 abstract "Structured noncoding RNAs perform many functions that are essential for protein synthesis, RNA processing, and gene regulation. Structured RNAs can be detected by comparative genomics, in which homologous sequences are identified and inspected for mutations that conserve RNA secondary structure. By applying a comparative genomics-based approach to genome and metagenome sequences from bacteria and archaea, we identified 104 candidate structured RNAs and inferred putative functions for many of these. Twelve candidate metabolite-binding RNAs were identified, three of which were validated, including one reported herein that binds the coenzyme S-adenosylmethionine. Newly identified cis-regulatory RNAs are implicated in photosynthesis or nitrogen regulation in cyanobacteria, purine and one-carbon metabolism, stomach infection by Helicobacter, and many other physiological processes. A candidate riboswitch termed crcB is represented in both bacteria and archaea. Another RNA motif may control gene expression from 3'-untranslated regions of mRNAs, which is unusual for bacteria. Many noncoding RNAs that likely act in trans are also revealed, and several of the noncoding RNA candidates are found mostly or exclusively in metagenome DNA sequences. This work greatly expands the variety of highly structured noncoding RNAs known to exist in bacteria and archaea and provides a starting point for biochemical and genetic studies needed to validate their biologic functions. Given the sustained rate of RNA discovery over several similar projects, we expect that far more structured RNAs remain to be discovered from bacterial and archaeal organisms." @default.
- W2122914162 created "2016-06-24" @default.
- W2122914162 creator A5000209540 @default.
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- W2122914162 creator A5056318126 @default.
- W2122914162 creator A5057146023 @default.
- W2122914162 creator A5058375820 @default.
- W2122914162 date "2010-01-01" @default.
- W2122914162 modified "2023-10-16" @default.
- W2122914162 title "Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea, and their metagenomes" @default.
- W2122914162 cites W1480754512 @default.
- W2122914162 cites W1517126644 @default.
- W2122914162 cites W1518638519 @default.
- W2122914162 cites W1549090124 @default.
- W2122914162 cites W1555727469 @default.
- W2122914162 cites W1575401889 @default.
- W2122914162 cites W1791999417 @default.
- W2122914162 cites W180545548 @default.
- W2122914162 cites W1822105579 @default.
- W2122914162 cites W1847569243 @default.
- W2122914162 cites W1900505923 @default.
- W2122914162 cites W1946545751 @default.
- W2122914162 cites W1964106002 @default.
- W2122914162 cites W1974489304 @default.
- W2122914162 cites W1975156117 @default.
- W2122914162 cites W1976021976 @default.
- W2122914162 cites W1976273670 @default.
- W2122914162 cites W1978030581 @default.
- W2122914162 cites W1978647329 @default.
- W2122914162 cites W1979622547 @default.
- W2122914162 cites W1984598765 @default.
- W2122914162 cites W1986008269 @default.
- W2122914162 cites W1986173091 @default.
- W2122914162 cites W1987139333 @default.
- W2122914162 cites W1988380385 @default.
- W2122914162 cites W1992770777 @default.
- W2122914162 cites W1993249234 @default.
- W2122914162 cites W1995076601 @default.
- W2122914162 cites W1995119217 @default.
- W2122914162 cites W1996987673 @default.
- W2122914162 cites W1998709767 @default.
- W2122914162 cites W2001031283 @default.
- W2122914162 cites W2001620437 @default.
- W2122914162 cites W2002555522 @default.
- W2122914162 cites W2003016263 @default.
- W2122914162 cites W2003658337 @default.
- W2122914162 cites W2005642753 @default.
- W2122914162 cites W2007604850 @default.
- W2122914162 cites W2009404076 @default.
- W2122914162 cites W2011368877 @default.
- W2122914162 cites W2012879790 @default.
- W2122914162 cites W2016102624 @default.
- W2122914162 cites W2016961011 @default.
- W2122914162 cites W2020812606 @default.
- W2122914162 cites W2023829651 @default.
- W2122914162 cites W2032510444 @default.
- W2122914162 cites W2033150420 @default.
- W2122914162 cites W2034411310 @default.
- W2122914162 cites W2035793410 @default.
- W2122914162 cites W2039338934 @default.
- W2122914162 cites W2041698201 @default.
- W2122914162 cites W2042398310 @default.
- W2122914162 cites W2044927713 @default.
- W2122914162 cites W2045401515 @default.
- W2122914162 cites W2048706341 @default.
- W2122914162 cites W2049105226 @default.
- W2122914162 cites W2055579692 @default.
- W2122914162 cites W2060118564 @default.
- W2122914162 cites W2061784511 @default.
- W2122914162 cites W2062955020 @default.
- W2122914162 cites W2063649343 @default.
- W2122914162 cites W2064345118 @default.
- W2122914162 cites W2066728696 @default.
- W2122914162 cites W2067060338 @default.
- W2122914162 cites W2071004407 @default.
- W2122914162 cites W2071779535 @default.
- W2122914162 cites W2072180333 @default.
- W2122914162 cites W2075147968 @default.
- W2122914162 cites W2078739770 @default.
- W2122914162 cites W2080254594 @default.
- W2122914162 cites W2080437762 @default.
- W2122914162 cites W2082124641 @default.
- W2122914162 cites W2082644333 @default.
- W2122914162 cites W2085672959 @default.
- W2122914162 cites W2088887932 @default.
- W2122914162 cites W2092202445 @default.
- W2122914162 cites W2092499114 @default.
- W2122914162 cites W2092802254 @default.
- W2122914162 cites W2093830129 @default.
- W2122914162 cites W2096647099 @default.
- W2122914162 cites W2097052411 @default.
- W2122914162 cites W2098508116 @default.
- W2122914162 cites W2098769462 @default.
- W2122914162 cites W2101107510 @default.
- W2122914162 cites W2103414965 @default.
- W2122914162 cites W2103439201 @default.