FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122936589> ?p ?o ?g. }

• W2122936589 endingPage "80" @default.
• W2122936589 startingPage "69" @default.
• W2122936589 abstract "Heparin-induced thrombocytopenia (HIT) is caused by antibodies, elicited in response to heparin anticoagulant therapy, which can cause extreme platelet activation and result in a highly procoagulant state. Most diagnostic tests for HIT antibodies measure in vitro platelet activation by detecting aggregation or granule release responses. This study demonstrates that the high level of activation by HIT antibodies leads to a rapid breakdown of platelet metabolic activity. Resting or mildly activated platelets metabolize tetrazolium-based indicator dye to a dark colored product, in proportion to cell concentration and dye incubation time. Highly activated, procoagulant platelets resulting from incubation with HIT antibodies fail to metabolize dye and remain light in color. The loss of ability to metabolically reduce indicator dye provides a colorimetric endpoint that can be used in an in vitro washed platelet activation assay to detect HIT antibodies. In a prospective evaluation, 145 diagnostic specimens were tested concurrently by both the colorimetric, dye reduction assay and the clinical laboratory standard, radiolabeled-serotonin release assay ((14)C-SRA). Results were in agreement for 96-100% of cases, depending on the chosen stringency of assay cut-off values. This study demonstrates that the metabolic dye reduction assay is comparable to the (14)C-SRA for HIT diagnosis. In addition, this novel assay may have even wider applicability, facilitating studies on the physiologic and clinical relevance of highly activated platelet populations." @default.
• W2122936589 created "2016-06-24" @default.
• W2122936589 creator A5052058621 @default.
• W2122936589 creator A5064909711 @default.
• W2122936589 creator A5074304553 @default.
• W2122936589 creator A5083350237 @default.
• W2122936589 date "2011-07-08" @default.
• W2122936589 modified "2023-09-24" @default.
• W2122936589 title "A colorimetric, metabolic dye reduction assay detects highly activated platelets: application in the diagnosis of heparin-induced thrombocytopenia" @default.
• W2122936589 cites W108425301 @default.
• W2122936589 cites W1519061284 @default.
• W2122936589 cites W1540375091 @default.
• W2122936589 cites W1812279404 @default.
• W2122936589 cites W1897676422 @default.
• W2122936589 cites W193975376 @default.
• W2122936589 cites W1975935770 @default.
• W2122936589 cites W1977631177 @default.
• W2122936589 cites W1984138867 @default.
• W2122936589 cites W1988789324 @default.
• W2122936589 cites W1999739482 @default.
• W2122936589 cites W2005073515 @default.
• W2122936589 cites W2013977506 @default.
• W2122936589 cites W2022645745 @default.
• W2122936589 cites W2023718145 @default.
• W2122936589 cites W2024341906 @default.
• W2122936589 cites W2025166330 @default.
• W2122936589 cites W2026192405 @default.
• W2122936589 cites W2039640090 @default.
• W2122936589 cites W2050014820 @default.
• W2122936589 cites W2050808293 @default.
• W2122936589 cites W2057686043 @default.
• W2122936589 cites W2063831497 @default.
• W2122936589 cites W2070063154 @default.
• W2122936589 cites W2082211789 @default.
• W2122936589 cites W2114918609 @default.
• W2122936589 cites W2145592812 @default.
• W2122936589 cites W2150922204 @default.
• W2122936589 cites W2153270908 @default.
• W2122936589 cites W2157415059 @default.
• W2122936589 cites W2274550965 @default.
• W2122936589 cites W2410474183 @default.
• W2122936589 cites W2572922408 @default.
• W2122936589 cites W36050078 @default.
• W2122936589 cites W4230777169 @default.
• W2122936589 cites W4251818240 @default.
• W2122936589 cites W73721486 @default.
• W2122936589 doi "https://doi.org/10.3109/09537104.2011.592957" @default.
• W2122936589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21736539" @default.
• W2122936589 hasPublicationYear "2011" @default.
• W2122936589 type Work @default.
• W2122936589 sameAs 2122936589 @default.
• W2122936589 citedByCount "4" @default.
• W2122936589 countsByYear W21229365892012 @default.
• W2122936589 countsByYear W21229365892018 @default.
• W2122936589 countsByYear W21229365892019 @default.
• W2122936589 crossrefType "journal-article" @default.
• W2122936589 hasAuthorship W2122936589A5052058621 @default.
• W2122936589 hasAuthorship W2122936589A5064909711 @default.
• W2122936589 hasAuthorship W2122936589A5074304553 @default.
• W2122936589 hasAuthorship W2122936589A5083350237 @default.
• W2122936589 hasConcept C153911025 @default.
• W2122936589 hasConcept C159654299 @default.
• W2122936589 hasConcept C159973064 @default.
• W2122936589 hasConcept C185592680 @default.
• W2122936589 hasConcept C202751555 @default.
• W2122936589 hasConcept C203014093 @default.
• W2122936589 hasConcept C25642318 @default.
• W2122936589 hasConcept C2776472838 @default.
• W2122936589 hasConcept C2776892249 @default.
• W2122936589 hasConcept C2777557582 @default.
• W2122936589 hasConcept C2778914503 @default.
• W2122936589 hasConcept C2780076745 @default.
• W2122936589 hasConcept C3018697912 @default.
• W2122936589 hasConcept C55493867 @default.
• W2122936589 hasConcept C71924100 @default.
• W2122936589 hasConcept C86803240 @default.
• W2122936589 hasConcept C89560881 @default.
• W2122936589 hasConcept C98274493 @default.
• W2122936589 hasConceptScore W2122936589C153911025 @default.
• W2122936589 hasConceptScore W2122936589C159654299 @default.
• W2122936589 hasConceptScore W2122936589C159973064 @default.
• W2122936589 hasConceptScore W2122936589C185592680 @default.
• W2122936589 hasConceptScore W2122936589C202751555 @default.
• W2122936589 hasConceptScore W2122936589C203014093 @default.
• W2122936589 hasConceptScore W2122936589C25642318 @default.
• W2122936589 hasConceptScore W2122936589C2776472838 @default.
• W2122936589 hasConceptScore W2122936589C2776892249 @default.
• W2122936589 hasConceptScore W2122936589C2777557582 @default.
• W2122936589 hasConceptScore W2122936589C2778914503 @default.
• W2122936589 hasConceptScore W2122936589C2780076745 @default.
• W2122936589 hasConceptScore W2122936589C3018697912 @default.
• W2122936589 hasConceptScore W2122936589C55493867 @default.
• W2122936589 hasConceptScore W2122936589C71924100 @default.
• W2122936589 hasConceptScore W2122936589C86803240 @default.
• W2122936589 hasConceptScore W2122936589C89560881 @default.
• W2122936589 hasConceptScore W2122936589C98274493 @default.
• W2122936589 hasIssue "1" @default.
• W2122936589 hasLocation W21229365891 @default.

• next