FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122939867> ?p ?o ?g. }

• W2122939867 endingPage "1599" @default.
• W2122939867 startingPage "1597" @default.
• W2122939867 abstract "The immunophilin FKBP12 binds the skeletal muscle Ca2+ release channel or ryanodine receptor (RyR1), but the functional consequences of this interaction are not known. In this study, we have generated skeletal muscle specific FKBP12-deficient mice to investigate the role of FKBP12 in skeletal muscle. Primary myotubes from these mice show no obvious change in either Ca2+ stores or resting Ca2+ levels but display decreased voltage-gated intracellular Ca2+ release and increased L-type Ca2+ currents. Consistent with the decreased voltage-gated Ca2+ release, maximal tetanic force production is decreased and the force frequency curves are shifted to the right in extensor digitorum longus (EDL) muscles of the mutant mice. In contrast, there is no decrease in maximal tetanic force production in the mutant diaphragm or soleus muscle. The force frequency curve is shifted to the left in the FKBP12-deficient diaphragm muscle compared with controls. No changes in myosin heavy chain (MHC) phenotype are observed in EDL or soleus muscle of the FKBP12-deficient mice, but diaphragm muscle displays an increased ratio of slow to fast MHC isoforms. Also, calcineurin levels are increased in the diaphragm of the mutant mice but not in the soleus or EDL. In summary, FKBP12 deficiency alters both orthograde and retrograde coupling between the L-type Ca2+ channel and RyR1 and the consequences of these changes depend on muscle type and activity. In highly used muscles such as the diaphragm, adaptation to the loss of FKBP12 occurs, possibly due to the increased Ca2+ influx." @default.
• W2122939867 created "2016-06-24" @default.
• W2122939867 creator A5011314369 @default.
• W2122939867 creator A5025785274 @default.
• W2122939867 creator A5033768941 @default.
• W2122939867 creator A5050406946 @default.
• W2122939867 creator A5050632280 @default.
• W2122939867 creator A5074327110 @default.
• W2122939867 creator A5081827574 @default.
• W2122939867 creator A5082837550 @default.
• W2122939867 date "2004-08-02" @default.
• W2122939867 modified "2023-10-10" @default.
• W2122939867 title "Altered excitation‐contraction coupling with skeletal muscle specific FKBP12 deficiency" @default.
• W2122939867 cites W1522775437 @default.
• W2122939867 cites W1887401978 @default.
• W2122939867 cites W1957733733 @default.
• W2122939867 cites W1963674209 @default.
• W2122939867 cites W1967287827 @default.
• W2122939867 cites W1971754413 @default.
• W2122939867 cites W1973150566 @default.
• W2122939867 cites W1976582108 @default.
• W2122939867 cites W1978879981 @default.
• W2122939867 cites W1984324503 @default.
• W2122939867 cites W1986465886 @default.
• W2122939867 cites W1995179761 @default.
• W2122939867 cites W2009667219 @default.
• W2122939867 cites W2010469212 @default.
• W2122939867 cites W2012247789 @default.
• W2122939867 cites W2024929666 @default.
• W2122939867 cites W2028225339 @default.
• W2122939867 cites W2034998738 @default.
• W2122939867 cites W2035885166 @default.
• W2122939867 cites W2047664621 @default.
• W2122939867 cites W2048139403 @default.
• W2122939867 cites W2049404915 @default.
• W2122939867 cites W2053127486 @default.
• W2122939867 cites W2076384379 @default.
• W2122939867 cites W2086162843 @default.
• W2122939867 cites W2108764665 @default.
• W2122939867 cites W2115263783 @default.
• W2122939867 cites W2123343796 @default.
• W2122939867 cites W2141385342 @default.
• W2122939867 cites W2149060964 @default.
• W2122939867 cites W2154198415 @default.
• W2122939867 cites W2185840810 @default.
• W2122939867 cites W2307344257 @default.
• W2122939867 cites W2341509841 @default.
• W2122939867 cites W4313371759 @default.
• W2122939867 doi "https://doi.org/10.1096/fj.04-1587fje" @default.
• W2122939867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15289441" @default.
• W2122939867 hasPublicationYear "2004" @default.
• W2122939867 type Work @default.
• W2122939867 sameAs 2122939867 @default.
• W2122939867 citedByCount "49" @default.
• W2122939867 countsByYear W21229398672012 @default.
• W2122939867 countsByYear W21229398672013 @default.
• W2122939867 countsByYear W21229398672014 @default.
• W2122939867 countsByYear W21229398672015 @default.
• W2122939867 countsByYear W21229398672016 @default.
• W2122939867 countsByYear W21229398672017 @default.
• W2122939867 countsByYear W21229398672018 @default.
• W2122939867 countsByYear W21229398672019 @default.
• W2122939867 countsByYear W21229398672020 @default.
• W2122939867 countsByYear W21229398672021 @default.
• W2122939867 countsByYear W21229398672023 @default.
• W2122939867 crossrefType "journal-article" @default.
• W2122939867 hasAuthorship W2122939867A5011314369 @default.
• W2122939867 hasAuthorship W2122939867A5025785274 @default.
• W2122939867 hasAuthorship W2122939867A5033768941 @default.
• W2122939867 hasAuthorship W2122939867A5050406946 @default.
• W2122939867 hasAuthorship W2122939867A5050632280 @default.
• W2122939867 hasAuthorship W2122939867A5074327110 @default.
• W2122939867 hasAuthorship W2122939867A5081827574 @default.
• W2122939867 hasAuthorship W2122939867A5082837550 @default.
• W2122939867 hasConcept C103486182 @default.
• W2122939867 hasConcept C113217602 @default.
• W2122939867 hasConcept C12554922 @default.
• W2122939867 hasConcept C126322002 @default.
• W2122939867 hasConcept C134018914 @default.
• W2122939867 hasConcept C185592680 @default.
• W2122939867 hasConcept C207200792 @default.
• W2122939867 hasConcept C2776333580 @default.
• W2122939867 hasConcept C2779959927 @default.
• W2122939867 hasConcept C3763915 @default.
• W2122939867 hasConcept C55493867 @default.
• W2122939867 hasConcept C6997183 @default.
• W2122939867 hasConcept C71924100 @default.
• W2122939867 hasConcept C79879829 @default.
• W2122939867 hasConcept C86803240 @default.
• W2122939867 hasConceptScore W2122939867C103486182 @default.
• W2122939867 hasConceptScore W2122939867C113217602 @default.
• W2122939867 hasConceptScore W2122939867C12554922 @default.
• W2122939867 hasConceptScore W2122939867C126322002 @default.
• W2122939867 hasConceptScore W2122939867C134018914 @default.
• W2122939867 hasConceptScore W2122939867C185592680 @default.
• W2122939867 hasConceptScore W2122939867C207200792 @default.
• W2122939867 hasConceptScore W2122939867C2776333580 @default.
• W2122939867 hasConceptScore W2122939867C2779959927 @default.

• next