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• W2123025061 endingPage "5299" @default.
• W2123025061 startingPage "5290" @default.
• W2123025061 abstract "ABSTRACT Survival in aerobic conditions is critical to the pathogenicity of many bacteria. To investigate the means of aerotolerance and resistance to oxidative stress in the catalase-negative organism Streptococcus pyogenes , we used a genomics-based approach to identify and inactivate homologues of two peroxidase genes, encoding alkyl hydroperoxidase ( ahpC ) and glutathione peroxidase ( gpoA ). Single and double mutants survived as well as the wild type under aerobic conditions. However, they were more susceptible than the wild type to growth suppression by paraquat and cumene hydroperoxide. In addition, we show that S. pyogenes demonstrates an inducible peroxide resistance response when treated with sublethal doses of peroxide. This resistance response was intact in ahpC and gpoA mutants but not in mutants lacking PerR, a repressor of several genes including ahpC and catalase ( katA ) in Bacillus subtilis . Because our data indicate that these peroxidase genes are not essential for aerotolerance or induced resistance to peroxide stress in S. pyogenes , genes for a novel mechanism of managing peroxide stress may be regulated by PerR in streptococci." @default.
• W2123025061 created "2016-06-24" @default.
• W2123025061 creator A5020638763 @default.
• W2123025061 creator A5051017654 @default.
• W2123025061 creator A5053217788 @default.
• W2123025061 date "2000-10-01" @default.
• W2123025061 modified "2023-09-23" @default.
• W2123025061 title "Aerotolerance and Peroxide Resistance in Peroxidase and PerR Mutants of <i>Streptococcus pyogenes</i>" @default.
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• W2123025061 doi "https://doi.org/10.1128/jb.182.19.5290-5299.2000" @default.
• W2123025061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/110969" @default.
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