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- W2123027776 abstract "Genetics of rheumatoid arthritis: GWAS and beyond Kate McAllister, Stephen Eyre, Gisela OrozcoArthritis Research United Kingdom Epidemiology Unit, Manchester Academic Health Science Centre, University of Manchester, UKAbstract: The study of complex genetics in autoimmune diseases has progressed at a tremendous pace over the last 4 years, as a direct result of the enormous gains made by genome wide association studies (GWAS). Novel genetic findings are continuously being reported alongside the rapid development of genetic technologies, sophisticated statistical analysis, and larger sample collections. It is now becoming clear that multiple genes contribute to disease risk in many complex genetic disorders including rheumatoid arthritis (RA) and that there are common genetic risk factors that underlie a spectrum of autoimmune diseases. This review details the current genetic landscape of RA, and describes what GWAS has taught us in terms of missing heritability, subsets of disease, existence of genetic heterogeneity, and shared autoimmune risk loci. Finally, this review addresses the initial challenges faced in translating the wealth of genetic findings into determining the biological mechanisms that contribute to the relationship between genotype and phenotype. Unraveling the mechanism of how genes directly influence the cause of RA will lead to a better understanding of the disease and will ultimately have a direct clinical impact, informing the development of new therapies that can be utilized in the treatment of RA.Keywords: rheumatoid arthritis, GWAS, fine mapping, immunochip, bioinformatics" @default.
- W2123027776 created "2016-06-24" @default.
- W2123027776 creator A5061399888 @default.
- W2123027776 creator A5068248314 @default.
- W2123027776 creator A5089398544 @default.
- W2123027776 date "2011-06-01" @default.
- W2123027776 modified "2023-09-30" @default.
- W2123027776 title "Genetics of rheumatoid arthritis: GWAS and beyond" @default.
- W2123027776 cites W103266845 @default.
- W2123027776 cites W163255345 @default.
- W2123027776 cites W183561440 @default.
- W2123027776 cites W185243033 @default.
- W2123027776 cites W1963639770 @default.
- W2123027776 cites W1963988946 @default.
- W2123027776 cites W1964289649 @default.
- W2123027776 cites W1965125415 @default.
- W2123027776 cites W1968739010 @default.
- W2123027776 cites W1969256933 @default.
- W2123027776 cites W1969940077 @default.
- W2123027776 cites W1969944084 @default.
- W2123027776 cites W1970011553 @default.
- W2123027776 cites W1971052194 @default.
- W2123027776 cites W1973652618 @default.
- W2123027776 cites W1973994873 @default.
- W2123027776 cites W1976057202 @default.
- W2123027776 cites W1976192764 @default.
- W2123027776 cites W1978124765 @default.
- W2123027776 cites W1978997769 @default.
- W2123027776 cites W1980516963 @default.
- W2123027776 cites W1982640617 @default.
- W2123027776 cites W1987677365 @default.
- W2123027776 cites W1989198317 @default.
- W2123027776 cites W1990226212 @default.
- W2123027776 cites W1991443138 @default.
- W2123027776 cites W1993333521 @default.
- W2123027776 cites W1993563063 @default.
- W2123027776 cites W1993936200 @default.
- W2123027776 cites W1994185764 @default.
- W2123027776 cites W1994402720 @default.
- W2123027776 cites W1994983680 @default.
- W2123027776 cites W1999353174 @default.
- W2123027776 cites W2002459476 @default.
- W2123027776 cites W2002599058 @default.
- W2123027776 cites W2005279553 @default.
- W2123027776 cites W2005405421 @default.
- W2123027776 cites W2008599922 @default.
- W2123027776 cites W2009087219 @default.
- W2123027776 cites W2014077667 @default.
- W2123027776 cites W2014431334 @default.
- W2123027776 cites W2015516540 @default.
- W2123027776 cites W2015865604 @default.
- W2123027776 cites W2015992070 @default.
- W2123027776 cites W2017548224 @default.
- W2123027776 cites W2019983262 @default.
- W2123027776 cites W2023073368 @default.
- W2123027776 cites W2026615227 @default.
- W2123027776 cites W2028882640 @default.
- W2123027776 cites W2029424880 @default.
- W2123027776 cites W2031755982 @default.
- W2123027776 cites W2031993658 @default.
- W2123027776 cites W2032767442 @default.
- W2123027776 cites W2032799815 @default.
- W2123027776 cites W2032940389 @default.
- W2123027776 cites W2035036601 @default.
- W2123027776 cites W2035688075 @default.
- W2123027776 cites W2037010889 @default.
- W2123027776 cites W2039167627 @default.
- W2123027776 cites W2042103448 @default.
- W2123027776 cites W2042183983 @default.
- W2123027776 cites W2044581569 @default.
- W2123027776 cites W2045247484 @default.
- W2123027776 cites W2045691392 @default.
- W2123027776 cites W2047825227 @default.
- W2123027776 cites W2047961787 @default.
- W2123027776 cites W2049358928 @default.
- W2123027776 cites W2051614646 @default.
- W2123027776 cites W2053138569 @default.
- W2123027776 cites W2053921780 @default.
- W2123027776 cites W2055026823 @default.
- W2123027776 cites W2055514573 @default.
- W2123027776 cites W2055552847 @default.
- W2123027776 cites W2055606249 @default.
- W2123027776 cites W2056696895 @default.
- W2123027776 cites W2064628575 @default.
- W2123027776 cites W2072164029 @default.
- W2123027776 cites W2073198149 @default.
- W2123027776 cites W2079039562 @default.
- W2123027776 cites W2084708009 @default.
- W2123027776 cites W2085630737 @default.
- W2123027776 cites W2087265576 @default.
- W2123027776 cites W2091943129 @default.
- W2123027776 cites W2093102863 @default.
- W2123027776 cites W2093120748 @default.
- W2123027776 cites W2094205468 @default.
- W2123027776 cites W2094619835 @default.
- W2123027776 cites W2095792567 @default.
- W2123027776 cites W2100068629 @default.
- W2123027776 cites W2100266959 @default.