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- W2123052851 abstract "Development of liver metastases is a frequent complication in the course of gastro-intestinal malignancies. After entering the liver via the portal circulation, blood-borne tumor cells that have been seeded from primary colorectal cancer, are first encountered by Kupffer cells (KC), which line the liver sinusoids. KC represent ∼10% of all liver cells, and have the ability to kill tumor cells. As such, they may play an important intrinsic role in the protection against outgrowth of hepatic metastases. Furthermore, the cytotoxic function of KC is increased upon stimulation with various biological response modifiers, such as interferon-γ, granulocyte macrophage-colony stimulating factor, antibodies and muramyl dipeptides. Therefore, enhancement of KC cytotoxic functions may represent an attractive treatment modality to prevent development of liver metastases in the clinical setting." @default.
- W2123052851 created "2016-06-24" @default.
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- W2123052851 date "2005-08-01" @default.
- W2123052851 modified "2023-10-17" @default.
- W2123052851 title "Therapeutic potential of Kupffer cells in prevention of liver metastases outgrowth" @default.
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- W2123052851 doi "https://doi.org/10.1016/j.imbio.2005.05.020" @default.
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