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• W2123053721 abstract "The human RNA helicase DDX1 in the DEAD-box family plays an important role in RNA processing and has been associated with HIV-1 replication and tumour progression. Whereas previously described DEAD-box proteins have a structurally conserved core, DDX1 shows a unique structural feature: a large SPRY-domain insertion in its RecA-like consensus fold. SPRY domains are known to function as protein-protein interaction platforms. Here, the crystal structure of the SPRY domain of human DDX1 (hDSPRY) is reported at 2.0 Å resolution. The structure reveals two layers of concave, antiparallel β-sheets that stack onto each other and a third β-sheet beneath the β-sandwich. A comparison with SPRY-domain structures from other eukaryotic proteins showed that the general β-sandwich fold is conserved; however, differences were detected in the loop regions, which were identified in other SPRY domains to be essential for interaction with cognate partners. In contrast, in hDSPRY these loop regions are not strictly conserved across species. Interestingly, though, a conserved patch of positive surface charge is found that may replace the connecting loops as a protein-protein interaction surface. The data presented here comprise the first structural information on DDX1 and provide insights into the unique domain architecture of this DEAD-box protein. By providing the structure of a putative interaction domain of DDX1, this work will serve as a basis for further studies of the interaction network within the hetero-oligomeric complexes of DDX1 and of its recruitment to the HIV-1 Rev protein as a viral replication factor." @default.
• W2123053721 created "2016-06-24" @default.
• W2123053721 creator A5039624302 @default.
• W2123053721 creator A5050353265 @default.
• W2123053721 date "2015-08-25" @default.
• W2123053721 modified "2023-09-27" @default.
• W2123053721 title "Structure of the SPRY domain of the human RNA helicase DDX1, a putative interaction platform within a DEAD-box protein" @default.
• W2123053721 cites W1966904972 @default.
• W2123053721 cites W1970997159 @default.
• W2123053721 cites W1973325087 @default.
• W2123053721 cites W1973610263 @default.
• W2123053721 cites W1978547782 @default.
• W2123053721 cites W1985233638 @default.
• W2123053721 cites W1986191025 @default.
• W2123053721 cites W1991118423 @default.
• W2123053721 cites W1995017064 @default.
• W2123053721 cites W1995100160 @default.
• W2123053721 cites W1996607909 @default.
• W2123053721 cites W1996690481 @default.
• W2123053721 cites W1999997768 @default.
• W2123053721 cites W2000840258 @default.
• W2123053721 cites W2001641653 @default.
• W2123053721 cites W2001665937 @default.
• W2123053721 cites W2006784855 @default.
• W2123053721 cites W2014694459 @default.
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• W2123053721 cites W2017874433 @default.
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• W2123053721 doi "https://doi.org/10.1107/s2053230x15013709" @default.
• W2123053721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4555926" @default.
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• W2123053721 hasPublicationYear "2015" @default.
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