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- W2123095375 abstract "The axis inhibition (Axin) scaffold protein colocalizes β-catenin, casein kinase Iα, and glycogen synthetase kinase 3β by their binding to Axin's long intrinsically disordered region, thereby yielding structured domains with flexible linkers. This complex leads to the phosphorylation of β-catenin, marking it for destruction. Fusing proteins with flexible linkers vastly accelerates chemical interactions between them by their colocalization. Here we propose that the complex works by random movements of a stochastic machine, not by coordinated conformational changes. This non-covalent, modular assembly process allows the various molecular machine components to be used in multiple processes." @default.
- W2123095375 created "2016-06-24" @default.
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- W2123095375 date "2013-04-18" @default.
- W2123095375 modified "2023-10-18" @default.
- W2123095375 title "Stochastic machines as a colocalization mechanism for scaffold protein function" @default.
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- W2123095375 doi "https://doi.org/10.1016/j.febslet.2013.04.006" @default.
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