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- W2123101867 abstract "disease; the recurrence rate in these patients was 75%, and in confirmed stage IA tumors the relapse rate may be lower than the reported 48%. Moreover, as suggested in the article by Billmire et al, COG criteria for surgical staging could lead to understaging in patients with greater than stage I disease. Two patients experienced relapse within 1 month (probably, the disease had already spread at the time of diagnosis), three patients experienced a retroperitoneal recurrence, and lymphnodal relapse was found in 37% of patients with a detected mass, indicating a possible predilection for lymphatic spread. The authors emphasized that although it could be argued that a more systematic surgical approach would have detected occult disease, the salvage rate with chemotherapy would be eventually equivalent.Wesuggestthatsurgicalorradiologicstagingmaybeusefulto identify patients who may benefit from adjuvant chemotherapy, given that, at present, we cannot rule out the possibility that postponing chemotherapy in disease with an occult stage greater than 1A may worsen the prognosis. Given the dearth of high-quality prospective trials on rare tumors,Billmireetal 1 shouldbecongratulatedfortheirstudy.However," @default.
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- W2123101867 date "2014-09-01" @default.
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- W2123101867 title "Surveillance Policy for Stage IA Malignant Ovarian Germ Cell Tumors in Children and Young Adults" @default.
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- W2123101867 doi "https://doi.org/10.1200/jco.2014.55.9617" @default.
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