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• W2123105877 abstract "Abstract: Extracts from bovine seminal vesicles have been shown to contain high concentrations of nerve growth factor (NGF)-like biological activity and of the NGF protein with properties corresponding to that of NGF from other sources. We now demonstrate that a second neuronotrophic protein, termed seminal vesicle-derived neuronotrophic factor (SVNF), is present in seminal vesicle extracts (SVEs), which could not be distinguished from NGF on the basis of biological activity. SVNF has neuronotrophic activity on NGF target cells like embryonic chicken sensory and sympathetic neurons, sympathetic neurons, and chromaffin cells from neonatal rats, but it is inactive on embryonic chicken ciliary or neonatal rat nodose ganglion neurons. It also stimulates fiber outgrowth from rat pheochromocytoma (PC 12) cells. In gel filtration chromatography on Biogel A 1.5 m, the activity is eluted with an apparent molecular weight of 40 kilodaltons, and by preparative isoelectric focusing, the isoelectric point was determined to be in the neutral range (6.8–7.8).The biological activity of SVNF, in contrast to that of NGF, is partially retained after preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis and can be electrophoretically eluted with an apparent molecular weight of 16–20 kilodaltons. Electrophoretically purified SVNF is not inhibited by antisera to mouse NGF, but its activity is increased > 10–fold in the presence of very low concentrations of NGF. For partially purified SVNF, a specific activity of 2.9–5.8 × 105 biological units/mg of protein was determined in the presence of subthreshold NGF concentrations. Thus, two neuronotrophic proteins, SVNF and NGF, are present in high amounts in extracts from bovine seminal vesicles, exhibit very similar and cooperative biological activities, but differ in molecular weights, isoelectric point, and immunological properties." @default.
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• W2123105877 date "1987-05-01" @default.
• W2123105877 modified "2023-09-27" @default.
• W2123105877 title "Characterization and Partial Purification of a Novel Neuronotrophic Factor from Bovine Seminal Vesicle" @default.
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• W2123105877 doi "https://doi.org/10.1111/j.1471-4159.1987.tb05681.x" @default.
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