FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123121206> ?p ?o ?g. }

• W2123121206 endingPage "948" @default.
• W2123121206 startingPage "943" @default.
• W2123121206 abstract "Summary Background and objectives Recent clinical trials on cholesterol-lowering in patients with CKD yielded conflicting results, which might have resulted from different treatment strategies. Serum cholesterol levels are determined by endogenous synthesis and intestinal absorption, which are differentially influenced by various classes of cholesterol-lowering agents. Assessing markers of cholesterol metabolism has thus been proposed for guidance of lipid-lowering therapy. This study analyzed surrogate markers of cholesterol absorption and synthesis in hemodialysis (HD) patients. Design, setting, participants, & measurements In 113 HD patients, lathosterol was measured as a marker of cholesterol synthesis and cholestanol was measured as a marker of cholesterol absorption via gas chromatography. Controls were 229 healthy persons. Overall survival in HD patients was recorded over 3.4-year follow-up. Results Compared with controls, HD patients had lower lathosterol and higher cholestanol levels ( P <0.001 for both). During follow-up, 58 patients died; higher cholestanol (indicating higher cholesterol absorption) predicted poor outcome among HD patients in multivariate Cox regression analysis after adjustment for potential confounders (hazard ratio for cholestanol above median, 2.24 [95% confidence interval (CI), 1.29–3.89]; P =0.004), whereas lower lathosterol (indicating lower cholesterol synthesis) did not (hazard ratio for lathosterol below median, 1.43 [95% CI, 0.81–2.50]; P =0.22). Conclusions This analysis of markers of cholesterol metabolism characterizes HD patients as cholesterol absorbers. In longitudinal analysis, higher levels of cholestanol were associated with all-cause mortality." @default.
• W2123121206 created "2016-06-24" @default.
• W2123121206 creator A5001741187 @default.
• W2123121206 creator A5011285126 @default.
• W2123121206 creator A5012419218 @default.
• W2123121206 creator A5018765344 @default.
• W2123121206 creator A5022295403 @default.
• W2123121206 creator A5026376858 @default.
• W2123121206 creator A5049797816 @default.
• W2123121206 creator A5069796252 @default.
• W2123121206 creator A5071412244 @default.
• W2123121206 creator A5087085147 @default.
• W2123121206 creator A5087097007 @default.
• W2123121206 date "2012-06-01" @default.
• W2123121206 modified "2023-10-16" @default.
• W2123121206 title "Cholesterol Synthesis, Cholesterol Absorption, and Mortality in Hemodialysis Patients" @default.
• W2123121206 cites W1963907865 @default.
• W2123121206 cites W1972507145 @default.
• W2123121206 cites W2001906656 @default.
• W2123121206 cites W2003121310 @default.
• W2123121206 cites W2016253197 @default.
• W2123121206 cites W2051753495 @default.
• W2123121206 cites W2063908227 @default.
• W2123121206 cites W2101967622 @default.
• W2123121206 cites W2110601215 @default.
• W2123121206 cites W2134120087 @default.
• W2123121206 cites W2153014921 @default.
• W2123121206 cites W2161280893 @default.
• W2123121206 cites W2162430779 @default.
• W2123121206 cites W2164089346 @default.
• W2123121206 doi "https://doi.org/10.2215/cjn.05170511" @default.
• W2123121206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22461539" @default.
• W2123121206 hasPublicationYear "2012" @default.
• W2123121206 type Work @default.
• W2123121206 sameAs 2123121206 @default.
• W2123121206 citedByCount "47" @default.
• W2123121206 countsByYear W21231212062012 @default.
• W2123121206 countsByYear W21231212062013 @default.
• W2123121206 countsByYear W21231212062014 @default.
• W2123121206 countsByYear W21231212062015 @default.
• W2123121206 countsByYear W21231212062016 @default.
• W2123121206 countsByYear W21231212062017 @default.
• W2123121206 countsByYear W21231212062018 @default.
• W2123121206 countsByYear W21231212062019 @default.
• W2123121206 countsByYear W21231212062020 @default.
• W2123121206 countsByYear W21231212062021 @default.
• W2123121206 countsByYear W21231212062022 @default.
• W2123121206 countsByYear W21231212062023 @default.
• W2123121206 crossrefType "journal-article" @default.
• W2123121206 hasAuthorship W2123121206A5001741187 @default.
• W2123121206 hasAuthorship W2123121206A5011285126 @default.
• W2123121206 hasAuthorship W2123121206A5012419218 @default.
• W2123121206 hasAuthorship W2123121206A5018765344 @default.
• W2123121206 hasAuthorship W2123121206A5022295403 @default.
• W2123121206 hasAuthorship W2123121206A5026376858 @default.
• W2123121206 hasAuthorship W2123121206A5049797816 @default.
• W2123121206 hasAuthorship W2123121206A5069796252 @default.
• W2123121206 hasAuthorship W2123121206A5071412244 @default.
• W2123121206 hasAuthorship W2123121206A5087085147 @default.
• W2123121206 hasAuthorship W2123121206A5087097007 @default.
• W2123121206 hasBestOaLocation W21231212061 @default.
• W2123121206 hasConcept C126322002 @default.
• W2123121206 hasConcept C134018914 @default.
• W2123121206 hasConcept C207103383 @default.
• W2123121206 hasConcept C2778063415 @default.
• W2123121206 hasConcept C2778163477 @default.
• W2123121206 hasConcept C2778718757 @default.
• W2123121206 hasConcept C2780022283 @default.
• W2123121206 hasConcept C2781471481 @default.
• W2123121206 hasConcept C2910061293 @default.
• W2123121206 hasConcept C44249647 @default.
• W2123121206 hasConcept C71924100 @default.
• W2123121206 hasConcept C90924648 @default.
• W2123121206 hasConceptScore W2123121206C126322002 @default.
• W2123121206 hasConceptScore W2123121206C134018914 @default.
• W2123121206 hasConceptScore W2123121206C207103383 @default.
• W2123121206 hasConceptScore W2123121206C2778063415 @default.
• W2123121206 hasConceptScore W2123121206C2778163477 @default.
• W2123121206 hasConceptScore W2123121206C2778718757 @default.
• W2123121206 hasConceptScore W2123121206C2780022283 @default.
• W2123121206 hasConceptScore W2123121206C2781471481 @default.
• W2123121206 hasConceptScore W2123121206C2910061293 @default.
• W2123121206 hasConceptScore W2123121206C44249647 @default.
• W2123121206 hasConceptScore W2123121206C71924100 @default.
• W2123121206 hasConceptScore W2123121206C90924648 @default.
• W2123121206 hasIssue "6" @default.
• W2123121206 hasLocation W21231212061 @default.
• W2123121206 hasLocation W21231212062 @default.
• W2123121206 hasOpenAccess W2123121206 @default.
• W2123121206 hasPrimaryLocation W21231212061 @default.
• W2123121206 hasRelatedWork W1505181157 @default.
• W2123121206 hasRelatedWork W1976829511 @default.
• W2123121206 hasRelatedWork W2002841317 @default.
• W2123121206 hasRelatedWork W2008910697 @default.
• W2123121206 hasRelatedWork W2061071087 @default.
• W2123121206 hasRelatedWork W2071689495 @default.
• W2123121206 hasRelatedWork W2123121206 @default.
• W2123121206 hasRelatedWork W2137844474 @default.

• next