Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123123969> ?p ?o ?g. }
- W2123123969 endingPage "218" @default.
- W2123123969 startingPage "212" @default.
- W2123123969 abstract "Several mammalian repetitive transposable genetic elements were characterized in recent years, and their role in mutagenesis is delineated in this review. Two main groups have been described: elements with symmetrical termini such as the murine IAP sequences and the human THE 1 elements and elements characterized by a poly-A rich tail at the 3′ end such as the SINE and LINE sequences. The characteristic property of such mobile elements to spread and integrate in the host genome leads to insertional mutagenesis. Both germline and somatic mutations have been documented resulting from the insertion of the various types of mammalian repetitive transposable genetic elements. As foreseen by Barbara McClintock, such genetic events can cause either the activation or the inactivation of specific genes, resulting in their identification via an altered phenotype. Several disease states, such as hemophilia and cancer, are the result of this apparent aspect of genome instability. © 1993 Wiley-Liss, Inc." @default.
- W2123123969 created "2016-06-24" @default.
- W2123123969 creator A5071994598 @default.
- W2123123969 creator A5082558562 @default.
- W2123123969 date "1993-01-01" @default.
- W2123123969 modified "2023-09-27" @default.
- W2123123969 title "Insertional mutagenesis by transposable elements in the mammalian genome" @default.
- W2123123969 cites W107231475 @default.
- W2123123969 cites W1426391262 @default.
- W2123123969 cites W1538258690 @default.
- W2123123969 cites W1569441480 @default.
- W2123123969 cites W1721319863 @default.
- W2123123969 cites W1844760932 @default.
- W2123123969 cites W1877182448 @default.
- W2123123969 cites W1968023581 @default.
- W2123123969 cites W1969989752 @default.
- W2123123969 cites W1971074898 @default.
- W2123123969 cites W1973746453 @default.
- W2123123969 cites W1975188816 @default.
- W2123123969 cites W1978483415 @default.
- W2123123969 cites W1978817316 @default.
- W2123123969 cites W1986319478 @default.
- W2123123969 cites W1987302058 @default.
- W2123123969 cites W1988218731 @default.
- W2123123969 cites W1989165429 @default.
- W2123123969 cites W1989814892 @default.
- W2123123969 cites W1990263899 @default.
- W2123123969 cites W1996781651 @default.
- W2123123969 cites W1999053228 @default.
- W2123123969 cites W2001266010 @default.
- W2123123969 cites W2001717481 @default.
- W2123123969 cites W2006394999 @default.
- W2123123969 cites W2012704007 @default.
- W2123123969 cites W2020615180 @default.
- W2123123969 cites W2020854816 @default.
- W2123123969 cites W2023118606 @default.
- W2123123969 cites W2023470881 @default.
- W2123123969 cites W2041794693 @default.
- W2123123969 cites W2049071198 @default.
- W2123123969 cites W2058063129 @default.
- W2123123969 cites W2059225262 @default.
- W2123123969 cites W2060651643 @default.
- W2123123969 cites W2064518632 @default.
- W2123123969 cites W2066031071 @default.
- W2123123969 cites W2070273393 @default.
- W2123123969 cites W2070423612 @default.
- W2123123969 cites W2070807615 @default.
- W2123123969 cites W2080056745 @default.
- W2123123969 cites W2080721346 @default.
- W2123123969 cites W2082454818 @default.
- W2123123969 cites W2086101682 @default.
- W2123123969 cites W2089184579 @default.
- W2123123969 cites W2092148833 @default.
- W2123123969 cites W2092275525 @default.
- W2123123969 cites W2115285376 @default.
- W2123123969 cites W2117621343 @default.
- W2123123969 cites W2122241386 @default.
- W2123123969 cites W2130578722 @default.
- W2123123969 cites W2137185016 @default.
- W2123123969 cites W2164374134 @default.
- W2123123969 cites W2167555142 @default.
- W2123123969 cites W2205143309 @default.
- W2123123969 cites W4234179782 @default.
- W2123123969 doi "https://doi.org/10.1002/em.2850210303" @default.
- W2123123969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8385004" @default.
- W2123123969 hasPublicationYear "1993" @default.
- W2123123969 type Work @default.
- W2123123969 sameAs 2123123969 @default.
- W2123123969 citedByCount "35" @default.
- W2123123969 countsByYear W21231239692012 @default.
- W2123123969 crossrefType "journal-article" @default.
- W2123123969 hasAuthorship W2123123969A5071994598 @default.
- W2123123969 hasAuthorship W2123123969A5082558562 @default.
- W2123123969 hasConcept C104317684 @default.
- W2123123969 hasConcept C107635520 @default.
- W2123123969 hasConcept C109825262 @default.
- W2123123969 hasConcept C127716648 @default.
- W2123123969 hasConcept C132533263 @default.
- W2123123969 hasConcept C141231307 @default.
- W2123123969 hasConcept C143425029 @default.
- W2123123969 hasConcept C16318435 @default.
- W2123123969 hasConcept C178169997 @default.
- W2123123969 hasConcept C197077220 @default.
- W2123123969 hasConcept C28693550 @default.
- W2123123969 hasConcept C4918238 @default.
- W2123123969 hasConcept C501734568 @default.
- W2123123969 hasConcept C54355233 @default.
- W2123123969 hasConcept C552990157 @default.
- W2123123969 hasConcept C86803240 @default.
- W2123123969 hasConceptScore W2123123969C104317684 @default.
- W2123123969 hasConceptScore W2123123969C107635520 @default.
- W2123123969 hasConceptScore W2123123969C109825262 @default.
- W2123123969 hasConceptScore W2123123969C127716648 @default.
- W2123123969 hasConceptScore W2123123969C132533263 @default.
- W2123123969 hasConceptScore W2123123969C141231307 @default.
- W2123123969 hasConceptScore W2123123969C143425029 @default.
- W2123123969 hasConceptScore W2123123969C16318435 @default.
- W2123123969 hasConceptScore W2123123969C178169997 @default.