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- W2123128528 abstract "B82L mouse fibroblasts respond to fibronectin or vitronectin via a syndecan-1-mediated activation of the αvβ5 integrin. Cells attached to syndecan-1-specific antibody display only filopodial extension. However, the syndecan-anchored cells extend lamellipodia when the antibody-substratum is supplemented with serum, or low concentrations of adsorbed vitronectin or fibronectin, that are not sufficient to activate the integrin when plated alone. Integrin activation is blocked by treatment with (Arg-Gly-Asp)-containing peptides and function-blocking antibodies that target αv integrins, as well as by siRNA-mediated silencing of β5 integrin expression. In addition, αvβ5-mediated cell attachment and spreading on high concentrations of vitronectin is blocked by competition with recombinant syndecan-1 ectodomain core protein and by downregulation of mouse syndecan-1 expression by mouse-specific siRNA. Taking advantage of the species-specificity of the siRNA, rescue experiments in which human syndecan-1 constructs are expressed trace the activation site to the syndecan-1 ectodomain. Moreover, both full-length mouse and human syndecan-1 co-immunoprecipitate with the β5 integrin subunit, but fail to do so if the syndecan is displaced by competition with soluble, recombinant syndecan-1 ectodomain. These results suggest that the ectodomain of the syndecan-1 core protein contains an active site that assembles into a complex with the αvβ5 integrin and regulates αvβ5 integrin activity." @default.
- W2123128528 created "2016-06-24" @default.
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- W2123128528 creator A5076389597 @default.
- W2123128528 creator A5081607559 @default.
- W2123128528 creator A5084124992 @default.
- W2123128528 date "2006-06-15" @default.
- W2123128528 modified "2023-10-18" @default.
- W2123128528 title "Syndecan-1 regulates αvβ5 integrin activity in B82L fibroblasts" @default.
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- W2123128528 cites W1604857812 @default.
- W2123128528 cites W1923175924 @default.
- W2123128528 cites W1970483666 @default.
- W2123128528 cites W1973474133 @default.
- W2123128528 cites W1977562862 @default.
- W2123128528 cites W1986612792 @default.
- W2123128528 cites W1987241587 @default.
- W2123128528 cites W1988176449 @default.
- W2123128528 cites W1989046246 @default.
- W2123128528 cites W1991708828 @default.
- W2123128528 cites W1991787503 @default.
- W2123128528 cites W1991839416 @default.
- W2123128528 cites W1993440705 @default.
- W2123128528 cites W1994970197 @default.
- W2123128528 cites W1996066976 @default.
- W2123128528 cites W1996103179 @default.
- W2123128528 cites W1996880045 @default.
- W2123128528 cites W2004369793 @default.
- W2123128528 cites W2007138679 @default.
- W2123128528 cites W2024422510 @default.
- W2123128528 cites W2025047729 @default.
- W2123128528 cites W2029386401 @default.
- W2123128528 cites W2039317622 @default.
- W2123128528 cites W2045434041 @default.
- W2123128528 cites W2045891730 @default.
- W2123128528 cites W2047013487 @default.
- W2123128528 cites W2048485183 @default.
- W2123128528 cites W2064208170 @default.
- W2123128528 cites W2065156837 @default.
- W2123128528 cites W2072103796 @default.
- W2123128528 cites W2072871114 @default.
- W2123128528 cites W2073355679 @default.
- W2123128528 cites W2073489309 @default.
- W2123128528 cites W2074086968 @default.
- W2123128528 cites W2074270121 @default.
- W2123128528 cites W2077576116 @default.
- W2123128528 cites W2079607346 @default.
- W2123128528 cites W2081096724 @default.
- W2123128528 cites W2081607618 @default.
- W2123128528 cites W2082548786 @default.
- W2123128528 cites W2084664594 @default.
- W2123128528 cites W2085560654 @default.
- W2123128528 cites W2097376134 @default.
- W2123128528 cites W2100363932 @default.
- W2123128528 cites W2104373491 @default.
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- W2123128528 cites W2114763381 @default.
- W2123128528 cites W2116938697 @default.
- W2123128528 cites W2121208343 @default.
- W2123128528 cites W2122306511 @default.
- W2123128528 cites W2123277882 @default.
- W2123128528 cites W2123807445 @default.
- W2123128528 cites W2135112491 @default.
- W2123128528 cites W2139981532 @default.
- W2123128528 cites W2140688937 @default.
- W2123128528 cites W2148230934 @default.
- W2123128528 cites W2152708219 @default.
- W2123128528 cites W2155293713 @default.
- W2123128528 cites W2155510991 @default.
- W2123128528 cites W2162312857 @default.
- W2123128528 cites W2186532357 @default.
- W2123128528 cites W2318767049 @default.
- W2123128528 cites W34966227 @default.
- W2123128528 cites W4213141530 @default.
- W2123128528 cites W4232908492 @default.
- W2123128528 cites W4243176216 @default.
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- W2123128528 doi "https://doi.org/10.1242/jcs.02970" @default.
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