FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123132596> ?p ?o ?g. }

• W2123132596 endingPage "76" @default.
• W2123132596 startingPage "2867" @default.
• W2123132596 abstract "Recently, we showed that preinvasive breast pathologies, such as usual hyperplasia, atypical hyperplasia, and carcinoma in situ, have an increased vascularity when compared with normal breast tissue (S. C. Heffelfinger et al., Clinical Cancer Res., 2: 1873-1878, 1996). To understand the mechanism of this increased vascularity, we examined by immunohistochemistry each of these pathological lesions for the expression of angiogenic growth factors. These studies showed that normal breast tissue contains numerous angiogenic agents, particularly vascular endothelial cell growth factor and basic fibroblast growth factor. At the transition from normal epithelium to proliferative breast disease, insulin-like growth factor (IGF) II expression was increased, primarily in the stroma and infiltrating leukocytes. However, among proliferative tissues, IGF I decreased with increasing vascularity. Finally, both epithelial vascular endothelial growth factor and epithelial and leukocytic platelet-derived endothelial cell growth factor increased at the transition to carcinoma in situ, whereas stromal and leukocytic basic fibroblast growth factor were elevated only in invasive carcinoma. Therefore, during histological progression there is also a complex progression of angiogenic growth factors. For CIS, two forms of vascularity are found: stromal microvascular density (MVD), and vascularity associated with the epithelial basement membrane (vascular score). There was 35% discordance between these two measurement systems. Among carcinoma in situ cases, decreases in stromal IGF II were associated with increasing vascular scores but not MVD, and increases in platelet-derived endothelial cell growth factor were associated with increasing MVD but not the vascular score. The presence of discordance and differential association with specific angiogenic agents suggests that these two forms of vascularity may be differentially regulated." @default.
• W2123132596 created "2016-06-24" @default.
• W2123132596 creator A5008922383 @default.
• W2123132596 creator A5048917628 @default.
• W2123132596 creator A5071665300 @default.
• W2123132596 creator A5079505620 @default.
• W2123132596 date "1999-10-01" @default.
• W2123132596 modified "2023-09-29" @default.
• W2123132596 title "Angiogenic growth factors in preinvasive breast disease." @default.
• W2123132596 cites W111955272 @default.
• W2123132596 cites W1434881831 @default.
• W2123132596 cites W1524623016 @default.
• W2123132596 cites W154610216 @default.
• W2123132596 cites W1564495345 @default.
• W2123132596 cites W1663121334 @default.
• W2123132596 cites W1665704747 @default.
• W2123132596 cites W1796060835 @default.
• W2123132596 cites W1902189520 @default.
• W2123132596 cites W1967870287 @default.
• W2123132596 cites W1969898679 @default.
• W2123132596 cites W1974025321 @default.
• W2123132596 cites W1976697969 @default.
• W2123132596 cites W1986727868 @default.
• W2123132596 cites W1986731330 @default.
• W2123132596 cites W1987030721 @default.
• W2123132596 cites W1990275850 @default.
• W2123132596 cites W2000019513 @default.
• W2123132596 cites W2002483118 @default.
• W2123132596 cites W2018342641 @default.
• W2123132596 cites W2023209386 @default.
• W2123132596 cites W2033791403 @default.
• W2123132596 cites W2034285427 @default.
• W2123132596 cites W2034822725 @default.
• W2123132596 cites W2038198672 @default.
• W2123132596 cites W2040530363 @default.
• W2123132596 cites W2053570562 @default.
• W2123132596 cites W2055218751 @default.
• W2123132596 cites W2063391840 @default.
• W2123132596 cites W2066935430 @default.
• W2123132596 cites W2076820945 @default.
• W2123132596 cites W2083307394 @default.
• W2123132596 cites W2087523741 @default.
• W2123132596 cites W2093498435 @default.
• W2123132596 cites W2093635855 @default.
• W2123132596 cites W2097316509 @default.
• W2123132596 cites W2100285612 @default.
• W2123132596 cites W2100837269 @default.
• W2123132596 cites W2105346716 @default.
• W2123132596 cites W2111900331 @default.
• W2123132596 cites W2117085705 @default.
• W2123132596 cites W2124803011 @default.
• W2123132596 cites W2128749862 @default.
• W2123132596 cites W2131572066 @default.
• W2123132596 cites W2158743409 @default.
• W2123132596 cites W2159699022 @default.
• W2123132596 cites W2319962899 @default.
• W2123132596 cites W2415201403 @default.
• W2123132596 cites W2497059924 @default.
• W2123132596 cites W2620321199 @default.
• W2123132596 cites W2109648811 @default.
• W2123132596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10537355" @default.
• W2123132596 hasPublicationYear "1999" @default.
• W2123132596 type Work @default.
• W2123132596 sameAs 2123132596 @default.
• W2123132596 citedByCount "36" @default.
• W2123132596 countsByYear W21231325962012 @default.
• W2123132596 countsByYear W21231325962013 @default.
• W2123132596 countsByYear W21231325962015 @default.
• W2123132596 countsByYear W21231325962016 @default.
• W2123132596 countsByYear W21231325962021 @default.
• W2123132596 countsByYear W21231325962022 @default.
• W2123132596 crossrefType "journal-article" @default.
• W2123132596 hasAuthorship W2123132596A5008922383 @default.
• W2123132596 hasAuthorship W2123132596A5048917628 @default.
• W2123132596 hasAuthorship W2123132596A5071665300 @default.
• W2123132596 hasAuthorship W2123132596A5079505620 @default.
• W2123132596 hasConcept C121608353 @default.
• W2123132596 hasConcept C126322002 @default.
• W2123132596 hasConcept C142724271 @default.
• W2123132596 hasConcept C167734588 @default.
• W2123132596 hasConcept C16930146 @default.
• W2123132596 hasConcept C170493617 @default.
• W2123132596 hasConcept C178596483 @default.
• W2123132596 hasConcept C2775960820 @default.
• W2123132596 hasConcept C2777025900 @default.
• W2123132596 hasConcept C2777546739 @default.
• W2123132596 hasConcept C2777562237 @default.
• W2123132596 hasConcept C2777587049 @default.
• W2123132596 hasConcept C2777661416 @default.
• W2123132596 hasConcept C2780394083 @default.
• W2123132596 hasConcept C3018521938 @default.
• W2123132596 hasConcept C502942594 @default.
• W2123132596 hasConcept C530470458 @default.
• W2123132596 hasConcept C71924100 @default.
• W2123132596 hasConcept C74373430 @default.
• W2123132596 hasConcept C86803240 @default.
• W2123132596 hasConceptScore W2123132596C121608353 @default.
• W2123132596 hasConceptScore W2123132596C126322002 @default.

• next