FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123133677> ?p ?o ?g. }

• W2123133677 endingPage "90" @default.
• W2123133677 startingPage "90" @default.
• W2123133677 abstract "Purified intravenous immunoglobulin (IVIG) obtained from the plasma of healthy humans is indicated for the treatment of primary immunodeficiency disorders associated with defects in humoral immunity. IVIG contains naturally occurring auto-antibodies, including antibodies (Abs) against β-amyloid (Aβ) peptides accumulating in the brains of Alzheimer's disease (AD) patients. IVIG has been shown to alleviate AD pathology when studied with mildly affected AD patients. Although its mechanisms-of-action have been broadly studied, it remains unresolved how IVIG affects the removal of natively formed brain Aβ deposits by primary astrocytes and microglia, two major cell types involved in the neuroinflammatory responses.We first determined the effect of IVIG on Aβ toxicity in primary neuronal cell culture. The mechanisms-of-action of IVIG in reduction of Aβ burden was analyzed with ex vivo assay. We studied whether IVIG solubilizes natively formed Aβ deposits from brain sections of APP/PS1 mice or promotes Aβ removal by primary glial cells. We determined the role of lysosomal degradation pathway and Aβ Abs in the IVIG-promoted reduction of Aβ. Finally, we studied the penetration of IVIG into the brain parenchyma and interaction with brain deposits of human Aβ in a mouse model of AD in vivo.IVIG was protective against Aβ toxicity in a primary mouse hippocampal neuron culture. IVIG modestly inhibited the fibrillization of synthetic Aβ1-42 but did not solubilize natively formed brain Aβ deposits ex vivo. IVIG enhanced microglia-mediated Aβ clearance ex vivo, with a mechanism linked to Aβ Abs and lysosomal degradation. The IVIG-enhanced Aβ clearance appears specific for microglia since IVIG did not affect Aβ clearance by astrocytes. The cellular mechanisms of Aβ clearance we observed have potential relevance in vivo since after peripheral administration IVIG penetrated to mouse brain tissue reaching highest concentrations in the hippocampus and bound selectively to Aβ deposits in co-localization with microglia.Our results demonstrate that IVIG promotes recognition and removal of natively formed brain Aβ deposits by primary microglia involving natural Aβ Abs in IVIG. These findings may have therapeutic relevance in vivo as IVIG penetrates through the blood-brain barrier and specifically binds to Aβ deposits in brain parenchyma." @default.
• W2123133677 created "2016-06-24" @default.
• W2123133677 creator A5000776705 @default.
• W2123133677 creator A5003020479 @default.
• W2123133677 creator A5005270668 @default.
• W2123133677 creator A5020702366 @default.
• W2123133677 creator A5031765078 @default.
• W2123133677 creator A5059497513 @default.
• W2123133677 creator A5064363817 @default.
• W2123133677 creator A5065951298 @default.
• W2123133677 creator A5070430837 @default.
• W2123133677 creator A5077906923 @default.
• W2123133677 creator A5081196992 @default.
• W2123133677 creator A5090473093 @default.
• W2123133677 date "2010-01-01" @default.
• W2123133677 modified "2023-10-17" @default.
• W2123133677 title "Human intravenous immunoglobulin provides protection against Aβ toxicity by multiple mechanisms in a mouse model of Alzheimer's disease" @default.
• W2123133677 cites W1199233662 @default.
• W2123133677 cites W1492780000 @default.
• W2123133677 cites W1528113046 @default.
• W2123133677 cites W1550693054 @default.
• W2123133677 cites W1559704329 @default.
• W2123133677 cites W1567490604 @default.
• W2123133677 cites W1585782290 @default.
• W2123133677 cites W1608895167 @default.
• W2123133677 cites W1621971853 @default.
• W2123133677 cites W1693283493 @default.
• W2123133677 cites W1823419340 @default.
• W2123133677 cites W1965275873 @default.
• W2123133677 cites W1967549235 @default.
• W2123133677 cites W1972543492 @default.
• W2123133677 cites W1978266853 @default.
• W2123133677 cites W1982506852 @default.
• W2123133677 cites W1989206786 @default.
• W2123133677 cites W1994462973 @default.
• W2123133677 cites W1997337646 @default.
• W2123133677 cites W1998227221 @default.
• W2123133677 cites W2002802598 @default.
• W2123133677 cites W2006376420 @default.
• W2123133677 cites W2006521244 @default.
• W2123133677 cites W2008645373 @default.
• W2123133677 cites W2009174342 @default.
• W2123133677 cites W2010476270 @default.
• W2123133677 cites W2015127947 @default.
• W2123133677 cites W2018626218 @default.
• W2123133677 cites W2019759965 @default.
• W2123133677 cites W2038405391 @default.
• W2123133677 cites W2041529353 @default.
• W2123133677 cites W2042400232 @default.
• W2123133677 cites W2044788039 @default.
• W2123133677 cites W2046704592 @default.
• W2123133677 cites W2052652421 @default.
• W2123133677 cites W2054525989 @default.
• W2123133677 cites W2056936299 @default.
• W2123133677 cites W2057725943 @default.
• W2123133677 cites W2058614488 @default.
• W2123133677 cites W2063696444 @default.
• W2123133677 cites W2063909850 @default.
• W2123133677 cites W2068346395 @default.
• W2123133677 cites W2074643069 @default.
• W2123133677 cites W2074753416 @default.
• W2123133677 cites W2076009773 @default.
• W2123133677 cites W2082487815 @default.
• W2123133677 cites W2085326534 @default.
• W2123133677 cites W2089894687 @default.
• W2123133677 cites W2092940965 @default.
• W2123133677 cites W2094660330 @default.
• W2123133677 cites W2096814558 @default.
• W2123133677 cites W2097867538 @default.
• W2123133677 cites W2099370040 @default.
• W2123133677 cites W2107015337 @default.
• W2123133677 cites W2108761681 @default.
• W2123133677 cites W2121753059 @default.
• W2123133677 cites W2124049467 @default.
• W2123133677 cites W2132576841 @default.
• W2123133677 cites W2136732030 @default.
• W2123133677 cites W2142140888 @default.
• W2123133677 cites W2142943752 @default.
• W2123133677 cites W2146550933 @default.
• W2123133677 cites W2147680452 @default.
• W2123133677 cites W2150999725 @default.
• W2123133677 cites W2164535032 @default.
• W2123133677 cites W2168025729 @default.
• W2123133677 cites W2169152986 @default.
• W2123133677 cites W2171311951 @default.
• W2123133677 cites W2469844384 @default.
• W2123133677 doi "https://doi.org/10.1186/1742-2094-7-90" @default.
• W2123133677 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3004875" @default.
• W2123133677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21138577" @default.
• W2123133677 hasPublicationYear "2010" @default.
• W2123133677 type Work @default.
• W2123133677 sameAs 2123133677 @default.
• W2123133677 citedByCount "92" @default.
• W2123133677 countsByYear W21231336772012 @default.
• W2123133677 countsByYear W21231336772013 @default.
• W2123133677 countsByYear W21231336772014 @default.
• W2123133677 countsByYear W21231336772015 @default.
• W2123133677 countsByYear W21231336772016 @default.

• next