FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123144543> ?p ?o ?g. }

• W2123144543 endingPage "892" @default.
• W2123144543 startingPage "885" @default.
• W2123144543 abstract "Primary aldosteronism is the most common form of secondary hypertension with hypokalemia and suppressed renin-angiotensin system caused by autonomous aldosterone production. Our aim was to compare zona glomerulosa (ZG) structure and function between control adrenals and the peritumoral tissue from patients operated on for aldosterone-producing adenoma. ZG morphology and CYP11B1, CYP11B2, and disabled 2 expression were studied in 15 control adrenals and 25 adrenals with aldosterone-producing adenoma. A transcriptome analysis was done using publicly available data sets. In control adrenals, ZG was discontinuous, and CYP11B2 expression was focal or partly continuous and localized to 3 structures, foci, megafoci, and aldosterone-producing cell clusters. CYP11B2 expression was restricted to a limited number of ZG cells expressing Dab2 but not CYP11B1; aldosterone-producing cell clusters were composed of cells with an intermediate phenotype expressing CYP11B2 but not disabled 2 or CYP11B1. In peritumoral tissue, large remodeling of the adrenal cortex was observed with increased nodulation and decreased vascularization that were not correlated with CYP11B2 expression. In 17 out of 25 adrenals, hyperplasia of adjacent ZG was observed with persistent expression of CYP11B2 that was extended to the entire ZG. In all of the adrenals from patients with aldosterone-producing adenoma, CYP11B2 expression was present in foci, megafoci, and aldosterone-producing cell clusters. Transcriptome profiling indicates a close relationship between peritumoral and control adrenal cortex. In conclusion, adrenal cortex remodeling, reduced vascularization, and ZG hyperplasia are major features of adrenals with aldosterone-producing adenoma. Transcriptional phenotyping is not in favor of this being an intermediate step toward the formation of aldosterone-producing adenoma." @default.
• W2123144543 created "2016-06-24" @default.
• W2123144543 creator A5017494730 @default.
• W2123144543 creator A5040128812 @default.
• W2123144543 creator A5040383170 @default.
• W2123144543 creator A5043545666 @default.
• W2123144543 creator A5045269059 @default.
• W2123144543 creator A5054769886 @default.
• W2123144543 creator A5057280958 @default.
• W2123144543 creator A5059427031 @default.
• W2123144543 creator A5068164050 @default.
• W2123144543 creator A5077098386 @default.
• W2123144543 creator A5077449453 @default.
• W2123144543 creator A5084238877 @default.
• W2123144543 date "2010-11-01" @default.
• W2123144543 modified "2023-10-17" @default.
• W2123144543 title "Adrenal Cortex Remodeling and Functional Zona Glomerulosa Hyperplasia in Primary Aldosteronism" @default.
• W2123144543 cites W1967908883 @default.
• W2123144543 cites W1983095160 @default.
• W2123144543 cites W1994199177 @default.
• W2123144543 cites W2002904441 @default.
• W2123144543 cites W2036848271 @default.
• W2123144543 cites W2043342005 @default.
• W2123144543 cites W2046922552 @default.
• W2123144543 cites W2054343869 @default.
• W2123144543 cites W2061006219 @default.
• W2123144543 cites W2062229790 @default.
• W2123144543 cites W2066489938 @default.
• W2123144543 cites W2117663124 @default.
• W2123144543 cites W2127109776 @default.
• W2123144543 cites W2138551378 @default.
• W2123144543 cites W2140244660 @default.
• W2123144543 cites W2157801554 @default.
• W2123144543 cites W4252016380 @default.
• W2123144543 cites W4368240604 @default.
• W2123144543 cites W4378951528 @default.
• W2123144543 doi "https://doi.org/10.1161/hypertensionaha.110.158543" @default.
• W2123144543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20937967" @default.
• W2123144543 hasPublicationYear "2010" @default.
• W2123144543 type Work @default.
• W2123144543 sameAs 2123144543 @default.
• W2123144543 citedByCount "129" @default.
• W2123144543 countsByYear W21231445432012 @default.
• W2123144543 countsByYear W21231445432013 @default.
• W2123144543 countsByYear W21231445432014 @default.
• W2123144543 countsByYear W21231445432015 @default.
• W2123144543 countsByYear W21231445432016 @default.
• W2123144543 countsByYear W21231445432017 @default.
• W2123144543 countsByYear W21231445432018 @default.
• W2123144543 countsByYear W21231445432019 @default.
• W2123144543 countsByYear W21231445432020 @default.
• W2123144543 countsByYear W21231445432021 @default.
• W2123144543 countsByYear W21231445432022 @default.
• W2123144543 countsByYear W21231445432023 @default.
• W2123144543 crossrefType "journal-article" @default.
• W2123144543 hasAuthorship W2123144543A5017494730 @default.
• W2123144543 hasAuthorship W2123144543A5040128812 @default.
• W2123144543 hasAuthorship W2123144543A5040383170 @default.
• W2123144543 hasAuthorship W2123144543A5043545666 @default.
• W2123144543 hasAuthorship W2123144543A5045269059 @default.
• W2123144543 hasAuthorship W2123144543A5054769886 @default.
• W2123144543 hasAuthorship W2123144543A5057280958 @default.
• W2123144543 hasAuthorship W2123144543A5059427031 @default.
• W2123144543 hasAuthorship W2123144543A5068164050 @default.
• W2123144543 hasAuthorship W2123144543A5077098386 @default.
• W2123144543 hasAuthorship W2123144543A5077449453 @default.
• W2123144543 hasAuthorship W2123144543A5084238877 @default.
• W2123144543 hasBestOaLocation W21231445431 @default.
• W2123144543 hasConcept C126322002 @default.
• W2123144543 hasConcept C134018914 @default.
• W2123144543 hasConcept C155392382 @default.
• W2123144543 hasConcept C198710026 @default.
• W2123144543 hasConcept C2776292634 @default.
• W2123144543 hasConcept C2777428134 @default.
• W2123144543 hasConcept C2777562237 @default.
• W2123144543 hasConcept C2777581072 @default.
• W2123144543 hasConcept C2777977426 @default.
• W2123144543 hasConcept C2778242168 @default.
• W2123144543 hasConcept C2778525890 @default.
• W2123144543 hasConcept C2780178468 @default.
• W2123144543 hasConcept C2780233176 @default.
• W2123144543 hasConcept C2780249997 @default.
• W2123144543 hasConcept C2780694816 @default.
• W2123144543 hasConcept C2780902042 @default.
• W2123144543 hasConcept C2908929049 @default.
• W2123144543 hasConcept C71315377 @default.
• W2123144543 hasConcept C71924100 @default.
• W2123144543 hasConcept C84393581 @default.
• W2123144543 hasConcept C86803240 @default.
• W2123144543 hasConceptScore W2123144543C126322002 @default.
• W2123144543 hasConceptScore W2123144543C134018914 @default.
• W2123144543 hasConceptScore W2123144543C155392382 @default.
• W2123144543 hasConceptScore W2123144543C198710026 @default.
• W2123144543 hasConceptScore W2123144543C2776292634 @default.
• W2123144543 hasConceptScore W2123144543C2777428134 @default.
• W2123144543 hasConceptScore W2123144543C2777562237 @default.
• W2123144543 hasConceptScore W2123144543C2777581072 @default.
• W2123144543 hasConceptScore W2123144543C2777977426 @default.

• next