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- W2123149390 abstract "<b>Objective:</b> To evaluate insulin resistance and systemic inflammation in older patients with systolic (SHF) or diastolic heart failure (DHF). <b>Patients:</b> 52 non-diabetic patients (> 70 and < 90 years old) with chronic heart failure (CHF) and hospitalised within the previous six months for heart failure were studied, together with a control group of older healthy volunteers (n = 26). On the basis of Doppler echocardiographic criteria patients were classed as having SHF (n = 27) or DHF (n = 25). <b>Main outcome measures:</b> Fasting glucose, insulin, C reactive protein, interleukin 6, and tumour necrosis factor α soluble receptor II (TNF-αSRII) concentrations were determined. Insulin resistance was estimated by the homeostasis model assessment (HOMA). <b>Results:</b> HOMA index (median, interquartile range) was higher in patients with DHF (1.77, 1.06–2.26) than in patients with SHF (0.97, 0.81–1.85) or healthy volunteers (1.04, 0.76–1.44; p = 0.01). After adjustment for body mass index, age, and use of angiotensin converting enzyme inhibitors, both groups of patients with CHF were more insulin resistant than were healthy volunteers (p = 0.02). C reactive protein, interleukin 6, and TNF-αSRII were all significantly (p < 0.001) higher in patients with DHF and SHF than in healthy volunteers. All markers of systemic inflammation were independently associated with the presence of clinical CHF. <b>Conclusion:</b> Insulin resistance and inflammatory activation are present in older patients with SHF and DHF." @default.
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- W2123149390 date "2005-01-01" @default.
- W2123149390 modified "2023-10-18" @default.
- W2123149390 title "Insulin resistance and inflammatory activation in older patients with systolic and diastolic heart failure" @default.
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- W2123149390 doi "https://doi.org/10.1136/hrt.2003.029652" @default.
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