Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123156966> ?p ?o ?g. }
- W2123156966 abstract "ABSTRACT The efficacy of current influenza vaccines requires a close antigenic match between circulating and vaccine strains. As such, timely identification of emerging influenza virus antigenic variants is central to the success of influenza vaccination programs. Empirical methods to determine influenza virus antigenic properties are time-consuming and mid-throughput and require live viruses. Here, we present a novel, experimentally validated, computational method for determining influenza virus antigenicity on the basis of hemagglutinin (HA) sequence. This method integrates a bootstrapped ridge regression with antigenic mapping to quantify antigenic distances by using influenza HA1 sequences. Our method was applied to H3N2 seasonal influenza viruses and identified the 13 previously recognized H3N2 antigenic clusters and the antigenic drift event of 2009 that led to a change of the H3N2 vaccine strain. IMPORTANCE This report supplies a novel method for quantifying antigenic distance and identifying antigenic variants using sequences alone. This method will be useful in influenza vaccine strain selection by significantly reducing the human labor efforts for serological characterization and will increase the likelihood of correct influenza vaccine candidate selection." @default.
- W2123156966 created "2016-06-24" @default.
- W2123156966 creator A5001033383 @default.
- W2123156966 creator A5004557326 @default.
- W2123156966 creator A5005839226 @default.
- W2123156966 creator A5024445390 @default.
- W2123156966 creator A5028692805 @default.
- W2123156966 creator A5038575631 @default.
- W2123156966 creator A5063493372 @default.
- W2123156966 creator A5078356550 @default.
- W2123156966 date "2013-08-30" @default.
- W2123156966 modified "2023-10-18" @default.
- W2123156966 title "Using Sequence Data To Infer the Antigenicity of Influenza Virus" @default.
- W2123156966 cites W1561081210 @default.
- W2123156966 cites W1965582988 @default.
- W2123156966 cites W1968808448 @default.
- W2123156966 cites W1970714421 @default.
- W2123156966 cites W1973887208 @default.
- W2123156966 cites W1978807612 @default.
- W2123156966 cites W1979158913 @default.
- W2123156966 cites W1986478210 @default.
- W2123156966 cites W1988533731 @default.
- W2123156966 cites W1989275845 @default.
- W2123156966 cites W1998591468 @default.
- W2123156966 cites W2008412982 @default.
- W2123156966 cites W2017795981 @default.
- W2123156966 cites W2039523393 @default.
- W2123156966 cites W2041646166 @default.
- W2123156966 cites W2044054342 @default.
- W2123156966 cites W2054798895 @default.
- W2123156966 cites W2055832244 @default.
- W2123156966 cites W2058144955 @default.
- W2123156966 cites W2060539718 @default.
- W2123156966 cites W2060990215 @default.
- W2123156966 cites W2062740562 @default.
- W2123156966 cites W2077124055 @default.
- W2123156966 cites W2078098398 @default.
- W2123156966 cites W2084645097 @default.
- W2123156966 cites W2099057076 @default.
- W2123156966 cites W2099576461 @default.
- W2123156966 cites W2105704721 @default.
- W2123156966 cites W2106396440 @default.
- W2123156966 cites W2128442209 @default.
- W2123156966 cites W2132926880 @default.
- W2123156966 cites W2139815785 @default.
- W2123156966 cites W2139841187 @default.
- W2123156966 cites W2144718643 @default.
- W2123156966 cites W2155467153 @default.
- W2123156966 cites W2157116486 @default.
- W2123156966 cites W2157229339 @default.
- W2123156966 cites W2157825883 @default.
- W2123156966 cites W2161845697 @default.
- W2123156966 cites W2169698020 @default.
- W2123156966 cites W2171288396 @default.
- W2123156966 cites W2173375845 @default.
- W2123156966 cites W2614049562 @default.
- W2123156966 doi "https://doi.org/10.1128/mbio.00230-13" @default.
- W2123156966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3705446" @default.
- W2123156966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23820391" @default.
- W2123156966 hasPublicationYear "2013" @default.
- W2123156966 type Work @default.
- W2123156966 sameAs 2123156966 @default.
- W2123156966 citedByCount "77" @default.
- W2123156966 countsByYear W21231569662013 @default.
- W2123156966 countsByYear W21231569662014 @default.
- W2123156966 countsByYear W21231569662015 @default.
- W2123156966 countsByYear W21231569662016 @default.
- W2123156966 countsByYear W21231569662017 @default.
- W2123156966 countsByYear W21231569662018 @default.
- W2123156966 countsByYear W21231569662019 @default.
- W2123156966 countsByYear W21231569662020 @default.
- W2123156966 countsByYear W21231569662021 @default.
- W2123156966 countsByYear W21231569662022 @default.
- W2123156966 countsByYear W21231569662023 @default.
- W2123156966 crossrefType "journal-article" @default.
- W2123156966 hasAuthorship W2123156966A5001033383 @default.
- W2123156966 hasAuthorship W2123156966A5004557326 @default.
- W2123156966 hasAuthorship W2123156966A5005839226 @default.
- W2123156966 hasAuthorship W2123156966A5024445390 @default.
- W2123156966 hasAuthorship W2123156966A5028692805 @default.
- W2123156966 hasAuthorship W2123156966A5038575631 @default.
- W2123156966 hasAuthorship W2123156966A5063493372 @default.
- W2123156966 hasAuthorship W2123156966A5078356550 @default.
- W2123156966 hasBestOaLocation W21231569663 @default.
- W2123156966 hasConcept C104317684 @default.
- W2123156966 hasConcept C142724271 @default.
- W2123156966 hasConcept C147483822 @default.
- W2123156966 hasConcept C159047783 @default.
- W2123156966 hasConcept C180915046 @default.
- W2123156966 hasConcept C191942190 @default.
- W2123156966 hasConcept C203014093 @default.
- W2123156966 hasConcept C21833749 @default.
- W2123156966 hasConcept C22070199 @default.
- W2123156966 hasConcept C2522874641 @default.
- W2123156966 hasConcept C2777546802 @default.
- W2123156966 hasConcept C2778692840 @default.
- W2123156966 hasConcept C2779026604 @default.
- W2123156966 hasConcept C2779134260 @default.
- W2123156966 hasConcept C2780689484 @default.
- W2123156966 hasConcept C2781416681 @default.