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- W2123156974 endingPage "2766" @default.
- W2123156974 startingPage "2753" @default.
- W2123156974 abstract "The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to complement activation. Their well-appreciated effector functions include chemotaxis and activation of granulocytes, mast cells and macrophages. Recent evidence suggests that ATs are also generated locally within tissues by pathogen-, cell-, or contact system-derived proteases. This local generation of ATs is important for their pleiotropic biologic effects beyond inflammation. The ATs exert most of the biologic activities through ligation of three cognate receptors, i.e. the C3a receptor, the C5a receptor and the C5a receptor-like, C5L2. Here, we will discuss recent findings suggesting that ATs regulate cell apoptosis, lipid metabolism as well as innate and adaptive immune responses through their impact on antigen-presenting cells and T cells. As we will outline, such regulatory functions of ATs and their receptors play important roles in the pathogenesis of allergy, autoimmunity, neurodegenerative diseases, cancer and infections with intracellular pathogens." @default.
- W2123156974 created "2016-06-24" @default.
- W2123156974 creator A5005325608 @default.
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- W2123156974 creator A5024929079 @default.
- W2123156974 creator A5034468688 @default.
- W2123156974 creator A5048940037 @default.
- W2123156974 creator A5050794917 @default.
- W2123156974 date "2009-09-01" @default.
- W2123156974 modified "2023-10-16" @default.
- W2123156974 title "The role of the anaphylatoxins in health and disease" @default.
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