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• W2123160696 abstract "The role of the hyperpolarization-activated current (Ih) mediated by HCN channels in temperature sensing by the hypothalamus was addressed. In warm-sensitive neurons (WSNs), exposure to ZD7288, an inhibitor of Ih mediated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, decreased their action potential amplitudes and frequencies significantly. By contrast, ZD7288 had little or no effect on temperature-insensitive neurons (TINs). Exposure of WSNs to ZD7288 led to a significant increase in the duration of the inter-spike interval and a reduction of Ih irreversibly. These results suggest that ZD7288 have the contrasting effects on the firing patterns of WSNs versus TINs, which implies HCN channels play a central role in temperature sensing by hypothalamic neurons." @default.
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• W2123160696 date "2012-01-01" @default.
• W2123160696 modified "2023-10-17" @default.
• W2123160696 title "Effects of ZD7288 on firing pattern of thermosensitive neurons isolated from hypothalamus" @default.
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• W2123160696 doi "https://doi.org/10.1016/j.neulet.2011.11.041" @default.
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