FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123162884> ?p ?o ?g. }

• W2123162884 endingPage "1106" @default.
• W2123162884 startingPage "1101" @default.
• W2123162884 abstract "An elevation in circulating serum uric acid is strongly associated with the development of hypertension and renal disease, but whether uric acid has a causal role or whether it simply indicates patients at risk for these complications remains controversial. We tested the hypothesis that uric acid may have a causal role in the development of hypertension and renal disease by examining the effects of mild hyperuricemia in rats. Mild hyperuricemia was induced in rats by providing a uricase inhibitor (oxonic acid) in the diet. Hyperuricemic rats developed elevated blood pressure after 3 weeks, whereas control rats remained normotensive. The development of hypertension was prevented by concurrent treatment with either a xanthine oxidase inhibitor (allopurinol) or a uricosuric agent (benziodarone), both of which lowered uric acid levels. Blood pressure could also be lowered by reducing uric acid levels with either allopurinol or oxonic acid withdrawal. A direct relationship was found between blood pressure and uric acid ( r =0.75, n=69), with a 10–mm Hg blood pressure increase for each 0.03-mmol/L (0.5-mg/dL) incremental rise in serum uric acid. The kidneys were devoid of urate crystals and were normal by light microscopy. However, immunohistochemical stains documented an ischemic type of injury with collagen deposition, macrophage infiltration, and an increase in tubular expression of osteopontin. Hyperuricemic rats also exhibited an increase in juxtaglomerular renin and a decrease in macula densa neuronal NO synthase. Both the renal injury and hypertension were reduced by treatment with enalapril or l -arginine. In conclusion, mild hyperuricemia causes hypertension and renal injury in the rat via a crystal-independent mechanism, with stimulation of the renin-angiotensin system and inhibition of neuronal NO synthase." @default.
• W2123162884 created "2016-06-24" @default.
• W2123162884 creator A5000127735 @default.
• W2123162884 creator A5002670298 @default.
• W2123162884 creator A5004471228 @default.
• W2123162884 creator A5025994433 @default.
• W2123162884 creator A5043738486 @default.
• W2123162884 creator A5059326014 @default.
• W2123162884 creator A5061472855 @default.
• W2123162884 creator A5079055699 @default.
• W2123162884 creator A5088071825 @default.
• W2123162884 date "2001-11-01" @default.
• W2123162884 modified "2023-10-16" @default.
• W2123162884 title "Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism" @default.
• W2123162884 cites W1928088016 @default.
• W2123162884 cites W1968290904 @default.
• W2123162884 cites W2015697722 @default.
• W2123162884 cites W2029615800 @default.
• W2123162884 cites W2093707453 @default.
• W2123162884 cites W2107419879 @default.
• W2123162884 cites W2113528337 @default.
• W2123162884 cites W2170812754 @default.
• W2123162884 cites W2213342011 @default.
• W2123162884 cites W2323300482 @default.
• W2123162884 cites W2327417059 @default.
• W2123162884 cites W2392101321 @default.
• W2123162884 doi "https://doi.org/10.1161/hy1101.092839" @default.
• W2123162884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11711505" @default.
• W2123162884 hasPublicationYear "2001" @default.
• W2123162884 type Work @default.
• W2123162884 sameAs 2123162884 @default.
• W2123162884 citedByCount "1095" @default.
• W2123162884 countsByYear W21231628842012 @default.
• W2123162884 countsByYear W21231628842013 @default.
• W2123162884 countsByYear W21231628842014 @default.
• W2123162884 countsByYear W21231628842015 @default.
• W2123162884 countsByYear W21231628842016 @default.
• W2123162884 countsByYear W21231628842017 @default.
• W2123162884 countsByYear W21231628842018 @default.
• W2123162884 countsByYear W21231628842019 @default.
• W2123162884 countsByYear W21231628842020 @default.
• W2123162884 countsByYear W21231628842021 @default.
• W2123162884 countsByYear W21231628842022 @default.
• W2123162884 countsByYear W21231628842023 @default.
• W2123162884 crossrefType "journal-article" @default.
• W2123162884 hasAuthorship W2123162884A5000127735 @default.
• W2123162884 hasAuthorship W2123162884A5002670298 @default.
• W2123162884 hasAuthorship W2123162884A5004471228 @default.
• W2123162884 hasAuthorship W2123162884A5025994433 @default.
• W2123162884 hasAuthorship W2123162884A5043738486 @default.
• W2123162884 hasAuthorship W2123162884A5059326014 @default.
• W2123162884 hasAuthorship W2123162884A5061472855 @default.
• W2123162884 hasAuthorship W2123162884A5079055699 @default.
• W2123162884 hasAuthorship W2123162884A5088071825 @default.
• W2123162884 hasBestOaLocation W21231628841 @default.
• W2123162884 hasConcept C126322002 @default.
• W2123162884 hasConcept C134018914 @default.
• W2123162884 hasConcept C181199279 @default.
• W2123162884 hasConcept C185592680 @default.
• W2123162884 hasConcept C198710026 @default.
• W2123162884 hasConcept C2777601384 @default.
• W2123162884 hasConcept C2777820942 @default.
• W2123162884 hasConcept C2778102346 @default.
• W2123162884 hasConcept C2779721657 @default.
• W2123162884 hasConcept C2779881121 @default.
• W2123162884 hasConcept C2780091579 @default.
• W2123162884 hasConcept C2780261098 @default.
• W2123162884 hasConcept C2781236342 @default.
• W2123162884 hasConcept C55493867 @default.
• W2123162884 hasConcept C71924100 @default.
• W2123162884 hasConcept C84393581 @default.
• W2123162884 hasConceptScore W2123162884C126322002 @default.
• W2123162884 hasConceptScore W2123162884C134018914 @default.
• W2123162884 hasConceptScore W2123162884C181199279 @default.
• W2123162884 hasConceptScore W2123162884C185592680 @default.
• W2123162884 hasConceptScore W2123162884C198710026 @default.
• W2123162884 hasConceptScore W2123162884C2777601384 @default.
• W2123162884 hasConceptScore W2123162884C2777820942 @default.
• W2123162884 hasConceptScore W2123162884C2778102346 @default.
• W2123162884 hasConceptScore W2123162884C2779721657 @default.
• W2123162884 hasConceptScore W2123162884C2779881121 @default.
• W2123162884 hasConceptScore W2123162884C2780091579 @default.
• W2123162884 hasConceptScore W2123162884C2780261098 @default.
• W2123162884 hasConceptScore W2123162884C2781236342 @default.
• W2123162884 hasConceptScore W2123162884C55493867 @default.
• W2123162884 hasConceptScore W2123162884C71924100 @default.
• W2123162884 hasConceptScore W2123162884C84393581 @default.
• W2123162884 hasIssue "5" @default.
• W2123162884 hasLocation W21231628841 @default.
• W2123162884 hasLocation W21231628842 @default.
• W2123162884 hasOpenAccess W2123162884 @default.
• W2123162884 hasPrimaryLocation W21231628841 @default.
• W2123162884 hasRelatedWork W1966731608 @default.
• W2123162884 hasRelatedWork W1981742949 @default.
• W2123162884 hasRelatedWork W1993899114 @default.
• W2123162884 hasRelatedWork W2016825263 @default.
• W2123162884 hasRelatedWork W2076678323 @default.
• W2123162884 hasRelatedWork W2089793564 @default.

• next