FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123165969> ?p ?o ?g. }

• W2123165969 endingPage "689" @default.
• W2123165969 startingPage "673" @default.
• W2123165969 abstract "1. The macroscopic and single channel gating characteristics of connexin (Cx) 50 gap junction channels between pairs of N2A neuroblastoma cells transfected with mouse Cx50 DNA were investigated using the dual whole-cell voltage clamp technique. 2. The macroscopic junctional current (Ij) of Cx50-transfected cells decayed exponentially with time in response to transjunctional voltage (Vj) steps (time constant (tau) of approximately 4 s at a Vj of 30-40 mV and 100-200 ms at a Vj of 80-100 mV). The steady-state junctional conductance (gj) was well described by a two-state Boltzmann equation. The half-inactivation voltage (V0), the ratio of minimal to maximal gj (gmin/gmax) and the equivalent gating charge were +/- 37 mV, 0.21 and 4, respectively. 3. The conductance of single Cx50 channels measured using patch pipettes containing 130 mM CsCl was 220 +/- 13.1 pS (12 cell pairs). A prominent residual or subconductance state corresponding to 43 +/- 4. 2 pS (10 cell pairs) was also observed at large Vj s. 4. The relationship between channel open probability (Po) and Vj was well described by a Boltzmann relationship with parameters similar to those obtained for macroscopic gj (V0 = 34 mV, gating charge = 4.25, maximum P= 0.98). The ensemble average of single channel currents at Vj = 50 mV declined in a monoexponential manner (tau = 905 ms), a value similar to the decline of the macroscopic Ij of Cx50 channels at the same voltage. 5. Ion substitution experiments indicated that Cx50 channels have a lower permeability to anions than to cations (transjunctional conductance of KCl vs. potassium glutamate (gammaj, KCl/gammaj,KGlut), 1.2; 6 cell pairs). 6. The results have important implications for understanding the role of connexins in tissues where Cx50 is a major gap junction component, including the lens." @default.
• W2123165969 created "2016-06-24" @default.
• W2123165969 creator A5027257928 @default.
• W2123165969 creator A5048676905 @default.
• W2123165969 creator A5049693824 @default.
• W2123165969 creator A5056576364 @default.
• W2123165969 creator A5059361186 @default.
• W2123165969 creator A5066760140 @default.
• W2123165969 date "1999-06-01" @default.
• W2123165969 modified "2023-10-15" @default.
• W2123165969 title "Voltage dependence of macroscopic and unitary currents of gap junction channels formed by mouse connexin50 expressed in rat neuroblastoma cells" @default.
• W2123165969 cites W110010700 @default.
• W2123165969 cites W135014788 @default.
• W2123165969 cites W166199280 @default.
• W2123165969 cites W1964547564 @default.
• W2123165969 cites W1967949725 @default.
• W2123165969 cites W1968411842 @default.
• W2123165969 cites W1977845454 @default.
• W2123165969 cites W1982231835 @default.
• W2123165969 cites W1986281847 @default.
• W2123165969 cites W1986662190 @default.
• W2123165969 cites W1987681547 @default.
• W2123165969 cites W1988316236 @default.
• W2123165969 cites W2004617457 @default.
• W2123165969 cites W2004853618 @default.
• W2123165969 cites W2006884634 @default.
• W2123165969 cites W2006905166 @default.
• W2123165969 cites W2011683698 @default.
• W2123165969 cites W2013800225 @default.
• W2123165969 cites W2017688904 @default.
• W2123165969 cites W2018517424 @default.
• W2123165969 cites W2023040290 @default.
• W2123165969 cites W2032962887 @default.
• W2123165969 cites W2040821726 @default.
• W2123165969 cites W2042890989 @default.
• W2123165969 cites W2049078511 @default.
• W2123165969 cites W2050159014 @default.
• W2123165969 cites W20508168 @default.
• W2123165969 cites W2051566911 @default.
• W2123165969 cites W2053751445 @default.
• W2123165969 cites W2075977132 @default.
• W2123165969 cites W2076700981 @default.
• W2123165969 cites W2088988088 @default.
• W2123165969 cites W2090627913 @default.
• W2123165969 cites W2098660246 @default.
• W2123165969 cites W2102155514 @default.
• W2123165969 cites W2103255264 @default.
• W2123165969 cites W2107051929 @default.
• W2123165969 cites W2107560584 @default.
• W2123165969 cites W2109127883 @default.
• W2123165969 cites W2113755529 @default.
• W2123165969 cites W2117539526 @default.
• W2123165969 cites W2132478632 @default.
• W2123165969 cites W2135942782 @default.
• W2123165969 cites W2138356252 @default.
• W2123165969 cites W2141504633 @default.
• W2123165969 cites W2147681062 @default.
• W2123165969 cites W2152719446 @default.
• W2123165969 cites W2168734089 @default.
• W2123165969 cites W2415912813 @default.
• W2123165969 doi "https://doi.org/10.1111/j.1469-7793.1999.0673s.x" @default.
• W2123165969 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2269370" @default.
• W2123165969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10358109" @default.
• W2123165969 hasPublicationYear "1999" @default.
• W2123165969 type Work @default.
• W2123165969 sameAs 2123165969 @default.
• W2123165969 citedByCount "98" @default.
• W2123165969 countsByYear W21231659692012 @default.
• W2123165969 countsByYear W21231659692013 @default.
• W2123165969 countsByYear W21231659692014 @default.
• W2123165969 countsByYear W21231659692015 @default.
• W2123165969 countsByYear W21231659692016 @default.
• W2123165969 countsByYear W21231659692017 @default.
• W2123165969 countsByYear W21231659692018 @default.
• W2123165969 countsByYear W21231659692019 @default.
• W2123165969 countsByYear W21231659692020 @default.
• W2123165969 countsByYear W21231659692021 @default.
• W2123165969 countsByYear W21231659692022 @default.
• W2123165969 countsByYear W21231659692023 @default.
• W2123165969 crossrefType "journal-article" @default.
• W2123165969 hasAuthorship W2123165969A5027257928 @default.
• W2123165969 hasAuthorship W2123165969A5048676905 @default.
• W2123165969 hasAuthorship W2123165969A5049693824 @default.
• W2123165969 hasAuthorship W2123165969A5056576364 @default.
• W2123165969 hasAuthorship W2123165969A5059361186 @default.
• W2123165969 hasAuthorship W2123165969A5066760140 @default.
• W2123165969 hasBestOaLocation W21231659691 @default.
• W2123165969 hasConcept C119599485 @default.
• W2123165969 hasConcept C121332964 @default.
• W2123165969 hasConcept C121932024 @default.
• W2123165969 hasConcept C12554922 @default.
• W2123165969 hasConcept C127413603 @default.
• W2123165969 hasConcept C147789679 @default.
• W2123165969 hasConcept C147944092 @default.
• W2123165969 hasConcept C158157758 @default.
• W2123165969 hasConcept C170493617 @default.
• W2123165969 hasConcept C181911157 @default.
• W2123165969 hasConcept C185592680 @default.

• next