FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123168045> ?p ?o ?g. }

• W2123168045 endingPage "673" @default.
• W2123168045 startingPage "663" @default.
• W2123168045 abstract "Abstract High-mobility group A2 (HMGA2) is commonly overexpressed in large leiomyomas. HMGA2 is an important regulator of cell growth, differentiation, apoptosis, and transformation. As a predicted target of Let-7 microRNAs (Let-7s), HMGA2 can be repressed by Let-7s in vitro. MicroRNA profiling analysis revealed that Let-7s were significantly dysregulated in uterine leiomyomas: high in small leiomyomas and lower in large leiomyomas. To evaluate whether Let-7 repression of HMGA2 plays a major role in leiomyomas, we analyzed the molecular relationship of HMGA2 and Let-7s, both in vitro and in vivo. We first characterized that exogenous Let-7 microRNAs could directly repress the dominant transcript of HMGA2, HMGA2a. This repression was also identified for two cryptic HMGA2 transcripts in primary leiomyoma cultures. Second, we found that the endogenous Let-7s were biologically active and played a major role in the regulation of HMGA2. Then, we illustrated that Let-7 repression of HMGA2 inhibited cellular proliferation. Finally, we examined the expression levels of Let-7c and HMGA2 in a large cohort of leiomyomas (n = 120), and we found high levels of Let-7 and low levels of HMGA2 in small leiomyomas, and low levels of Let-7 and high levels of HMGA2 in large leiomyomas. Our findings suggest that the Let-7–mediated repression of HMGA2 mechanism can be an important molecular event in leiomyoma growth. (Mol Cancer Res 2008;6(4):663–73)" @default.
• W2123168045 created "2016-06-24" @default.
• W2123168045 creator A5000882396 @default.
• W2123168045 creator A5009486201 @default.
• W2123168045 creator A5011447518 @default.
• W2123168045 creator A5027047231 @default.
• W2123168045 creator A5044083374 @default.
• W2123168045 creator A5044849611 @default.
• W2123168045 creator A5065912386 @default.
• W2123168045 date "2008-04-01" @default.
• W2123168045 modified "2023-09-23" @default.
• W2123168045 title "Antiproliferative Effects by <i>Let-7</i> Repression of High-Mobility Group A2 in Uterine Leiomyoma" @default.
• W2123168045 cites W1900976126 @default.
• W2123168045 cites W1920303762 @default.
• W2123168045 cites W1958284284 @default.
• W2123168045 cites W1969018878 @default.
• W2123168045 cites W1977808594 @default.
• W2123168045 cites W1986178112 @default.
• W2123168045 cites W1993719542 @default.
• W2123168045 cites W2004993869 @default.
• W2123168045 cites W2007515109 @default.
• W2123168045 cites W2009229545 @default.
• W2123168045 cites W2017802973 @default.
• W2123168045 cites W2036294319 @default.
• W2123168045 cites W2038743660 @default.
• W2123168045 cites W2040191060 @default.
• W2123168045 cites W2044268365 @default.
• W2123168045 cites W2046436315 @default.
• W2123168045 cites W2047508831 @default.
• W2123168045 cites W2063424945 @default.
• W2123168045 cites W2065221264 @default.
• W2123168045 cites W2069759108 @default.
• W2123168045 cites W2075086580 @default.
• W2123168045 cites W2076475787 @default.
• W2123168045 cites W2081709171 @default.
• W2123168045 cites W2081807421 @default.
• W2123168045 cites W2082858783 @default.
• W2123168045 cites W2083381199 @default.
• W2123168045 cites W2090349620 @default.
• W2123168045 cites W2094659333 @default.
• W2123168045 cites W2095125813 @default.
• W2123168045 cites W2103005112 @default.
• W2123168045 cites W2110666579 @default.
• W2123168045 cites W2119967589 @default.
• W2123168045 cites W2123663533 @default.
• W2123168045 cites W2128875155 @default.
• W2123168045 cites W2135810600 @default.
• W2123168045 cites W2137665434 @default.
• W2123168045 cites W2139141502 @default.
• W2123168045 cites W2144038313 @default.
• W2123168045 cites W2145682669 @default.
• W2123168045 cites W2150536104 @default.
• W2123168045 cites W2151922790 @default.
• W2123168045 cites W2152041515 @default.
• W2123168045 cites W2155123146 @default.
• W2123168045 cites W2164991984 @default.
• W2123168045 cites W2170647698 @default.
• W2123168045 doi "https://doi.org/10.1158/1541-7786.mcr-07-0370" @default.
• W2123168045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18403645" @default.
• W2123168045 hasPublicationYear "2008" @default.
• W2123168045 type Work @default.
• W2123168045 sameAs 2123168045 @default.
• W2123168045 citedByCount "135" @default.
• W2123168045 countsByYear W21231680452012 @default.
• W2123168045 countsByYear W21231680452013 @default.
• W2123168045 countsByYear W21231680452014 @default.
• W2123168045 countsByYear W21231680452015 @default.
• W2123168045 countsByYear W21231680452016 @default.
• W2123168045 countsByYear W21231680452017 @default.
• W2123168045 countsByYear W21231680452018 @default.
• W2123168045 countsByYear W21231680452019 @default.
• W2123168045 countsByYear W21231680452020 @default.
• W2123168045 countsByYear W21231680452022 @default.
• W2123168045 countsByYear W21231680452023 @default.
• W2123168045 crossrefType "journal-article" @default.
• W2123168045 hasAuthorship W2123168045A5000882396 @default.
• W2123168045 hasAuthorship W2123168045A5009486201 @default.
• W2123168045 hasAuthorship W2123168045A5011447518 @default.
• W2123168045 hasAuthorship W2123168045A5027047231 @default.
• W2123168045 hasAuthorship W2123168045A5044083374 @default.
• W2123168045 hasAuthorship W2123168045A5044849611 @default.
• W2123168045 hasAuthorship W2123168045A5065912386 @default.
• W2123168045 hasConcept C104317684 @default.
• W2123168045 hasConcept C142724271 @default.
• W2123168045 hasConcept C145059251 @default.
• W2123168045 hasConcept C150194340 @default.
• W2123168045 hasConcept C186310378 @default.
• W2123168045 hasConcept C190283241 @default.
• W2123168045 hasConcept C2529059 @default.
• W2123168045 hasConcept C2777795800 @default.
• W2123168045 hasConcept C3017725331 @default.
• W2123168045 hasConcept C502942594 @default.
• W2123168045 hasConcept C54355233 @default.
• W2123168045 hasConcept C62112901 @default.
• W2123168045 hasConcept C71924100 @default.
• W2123168045 hasConcept C86803240 @default.
• W2123168045 hasConceptScore W2123168045C104317684 @default.
• W2123168045 hasConceptScore W2123168045C142724271 @default.

• next