Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123168098> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2123168098 endingPage "2314" @default.
- W2123168098 startingPage "2312" @default.
- W2123168098 abstract "Mucormycosis is a rare but refractory mycosis with high mortality. Few therapeutic options are available and novel strategies are needed. Calcineurin inhibitors are known to have antifungal activity, including synergy with various antifungals. We examined the interaction of caspofungin with calcineurin inhibitors and sirolimus against Glomeromycetes. Twenty-six strains of Glomeromycetes representing seven species (Rhizopus arrhizus, Rhizopus microsporus, Mucor sp., Rhizomucor pusillus, Cunninghamellaberthollettiae, Mycocladus corymbifera and Apophysomyces elegans) were studied. Antifungal susceptibility testing was performed according to CLSI M38-A2, modified for chequerboard dilution testing using the minimum effective concentration (MEC) endpoint for caspofungin and calcineurin inhibitors/sirolimus. Synergy was defined as a fractional inhibitory concentration index ≤0.5, indifference >0.5 to ≤4.0 and antagonism >4.0. Caspofungin had no intrinsic activity against Glomeromycetes (MEC >8 mg/L). The combination of caspofungin with calcineurin inhibitors and sirolimus showed synergy in seven isolates. In the presence of calcineurin inhibitors and sirolimus, the MEC of caspofungin was significantly lowered (>4-fold) in 24 and 7 isolates, respectively. All species showed lower MECs of caspofungin with calcineurin inhibitors and only R. arrhizus, Mucor sp. and R. pusillus showed lower MECs with sirolimus. No antagonism was observed. Calcineurin inhibitors and sirolimus significantly lowered MECs of caspofungin for Glomeromycetes, with occasional synergy observed. The clinical significance of this should be further investigated." @default.
- W2123168098 created "2016-06-24" @default.
- W2123168098 creator A5048105708 @default.
- W2123168098 creator A5057437852 @default.
- W2123168098 date "2011-07-26" @default.
- W2123168098 modified "2023-09-27" @default.
- W2123168098 title "In vitro interaction of caspofungin and immunosuppressives against agents of mucormycosis" @default.
- W2123168098 cites W1979891814 @default.
- W2123168098 cites W2016562927 @default.
- W2123168098 cites W2021832667 @default.
- W2123168098 cites W2108009652 @default.
- W2123168098 cites W2108597723 @default.
- W2123168098 cites W2118776720 @default.
- W2123168098 cites W2134569385 @default.
- W2123168098 cites W2155809016 @default.
- W2123168098 cites W2168675232 @default.
- W2123168098 doi "https://doi.org/10.1093/jac/dkr297" @default.
- W2123168098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21795260" @default.
- W2123168098 hasPublicationYear "2011" @default.
- W2123168098 type Work @default.
- W2123168098 sameAs 2123168098 @default.
- W2123168098 citedByCount "15" @default.
- W2123168098 countsByYear W21231680982013 @default.
- W2123168098 countsByYear W21231680982014 @default.
- W2123168098 countsByYear W21231680982015 @default.
- W2123168098 countsByYear W21231680982016 @default.
- W2123168098 countsByYear W21231680982018 @default.
- W2123168098 countsByYear W21231680982019 @default.
- W2123168098 countsByYear W21231680982022 @default.
- W2123168098 countsByYear W21231680982023 @default.
- W2123168098 crossrefType "journal-article" @default.
- W2123168098 hasAuthorship W2123168098A5048105708 @default.
- W2123168098 hasAuthorship W2123168098A5057437852 @default.
- W2123168098 hasBestOaLocation W21231680981 @default.
- W2123168098 hasConcept C126322002 @default.
- W2123168098 hasConcept C128057223 @default.
- W2123168098 hasConcept C170493617 @default.
- W2123168098 hasConcept C185592680 @default.
- W2123168098 hasConcept C2777383412 @default.
- W2123168098 hasConcept C2777921159 @default.
- W2123168098 hasConcept C2779548794 @default.
- W2123168098 hasConcept C2779629538 @default.
- W2123168098 hasConcept C2780402444 @default.
- W2123168098 hasConcept C2911091166 @default.
- W2123168098 hasConcept C55493867 @default.
- W2123168098 hasConcept C71924100 @default.
- W2123168098 hasConcept C86803240 @default.
- W2123168098 hasConcept C89423630 @default.
- W2123168098 hasConcept C98274493 @default.
- W2123168098 hasConceptScore W2123168098C126322002 @default.
- W2123168098 hasConceptScore W2123168098C128057223 @default.
- W2123168098 hasConceptScore W2123168098C170493617 @default.
- W2123168098 hasConceptScore W2123168098C185592680 @default.
- W2123168098 hasConceptScore W2123168098C2777383412 @default.
- W2123168098 hasConceptScore W2123168098C2777921159 @default.
- W2123168098 hasConceptScore W2123168098C2779548794 @default.
- W2123168098 hasConceptScore W2123168098C2779629538 @default.
- W2123168098 hasConceptScore W2123168098C2780402444 @default.
- W2123168098 hasConceptScore W2123168098C2911091166 @default.
- W2123168098 hasConceptScore W2123168098C55493867 @default.
- W2123168098 hasConceptScore W2123168098C71924100 @default.
- W2123168098 hasConceptScore W2123168098C86803240 @default.
- W2123168098 hasConceptScore W2123168098C89423630 @default.
- W2123168098 hasConceptScore W2123168098C98274493 @default.
- W2123168098 hasIssue "10" @default.
- W2123168098 hasLocation W21231680981 @default.
- W2123168098 hasLocation W21231680982 @default.
- W2123168098 hasOpenAccess W2123168098 @default.
- W2123168098 hasPrimaryLocation W21231680981 @default.
- W2123168098 hasRelatedWork W1522009253 @default.
- W2123168098 hasRelatedWork W1561703469 @default.
- W2123168098 hasRelatedWork W1966785288 @default.
- W2123168098 hasRelatedWork W2041898668 @default.
- W2123168098 hasRelatedWork W2054066544 @default.
- W2123168098 hasRelatedWork W2094073838 @default.
- W2123168098 hasRelatedWork W2123168098 @default.
- W2123168098 hasRelatedWork W2130219955 @default.
- W2123168098 hasRelatedWork W2444456071 @default.
- W2123168098 hasRelatedWork W4213378507 @default.
- W2123168098 hasVolume "66" @default.
- W2123168098 isParatext "false" @default.
- W2123168098 isRetracted "false" @default.
- W2123168098 magId "2123168098" @default.
- W2123168098 workType "article" @default.