Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123174893> ?p ?o ?g. }
- W2123174893 endingPage "424" @default.
- W2123174893 startingPage "417" @default.
- W2123174893 abstract "The role of preS domains of the hepatitis B virus (HBV) envelope proteins in the first steps of viral infection has been restricted to their implication in virus attachment to a putative hepatocyte receptor. In order to explore a fusion activity in these regions, we used recombinant preS domains to characterize their interaction with liposomes. Binding experiments carried out with NBD-labeled proteins indicated that preS were able to interact in a monomeric way with acidic phospholipid vesicles, being the partition coefficient similar to that described for peptides which can insert deeply into bilayers. Fluorescence depolarization of DPH-labeled vesicles confirmed the specificity for negative charged phospholipids. Upon interaction the proteins induced aggregation, lipid mixing and release of internal contents of acidic vesicles at both acid and neutral pH in a concentration-dependent manner. Taken together, all these data indicate that preS domains are able to insert into the hydrophobic core of the bilayer. Moreover, the insertion resulted in a protein conformational change which increased the helical content. Therefore all these results suggest that, besides their participation in the recognition of a cellular receptor, the preS domains could be involved in the fusion mechanism of HBV with the plasma membrane of target cells." @default.
- W2123174893 created "2016-06-24" @default.
- W2123174893 creator A5030833355 @default.
- W2123174893 creator A5060650751 @default.
- W2123174893 creator A5063152845 @default.
- W2123174893 creator A5072509384 @default.
- W2123174893 creator A5082063349 @default.
- W2123174893 creator A5086985368 @default.
- W2123174893 date "2009-02-01" @default.
- W2123174893 modified "2023-10-12" @default.
- W2123174893 title "Interaction of preS domains of hepatitis B virus with phospholipid vesicles" @default.
- W2123174893 cites W1503300581 @default.
- W2123174893 cites W1591950279 @default.
- W2123174893 cites W1607766894 @default.
- W2123174893 cites W167632067 @default.
- W2123174893 cites W1822042631 @default.
- W2123174893 cites W1837032642 @default.
- W2123174893 cites W1860897788 @default.
- W2123174893 cites W1880341895 @default.
- W2123174893 cites W1964671048 @default.
- W2123174893 cites W1975562030 @default.
- W2123174893 cites W1978763290 @default.
- W2123174893 cites W1980441078 @default.
- W2123174893 cites W1983361428 @default.
- W2123174893 cites W1983748518 @default.
- W2123174893 cites W1984198411 @default.
- W2123174893 cites W1987131886 @default.
- W2123174893 cites W1991079346 @default.
- W2123174893 cites W1992798775 @default.
- W2123174893 cites W2001825873 @default.
- W2123174893 cites W2017923262 @default.
- W2123174893 cites W2018899371 @default.
- W2123174893 cites W2023054692 @default.
- W2123174893 cites W2023274408 @default.
- W2123174893 cites W2035664036 @default.
- W2123174893 cites W2049844451 @default.
- W2123174893 cites W2053324553 @default.
- W2123174893 cites W2062684349 @default.
- W2123174893 cites W2071507299 @default.
- W2123174893 cites W2085398130 @default.
- W2123174893 cites W2087870820 @default.
- W2123174893 cites W2088141654 @default.
- W2123174893 cites W2095124275 @default.
- W2123174893 cites W2103191417 @default.
- W2123174893 cites W2105800692 @default.
- W2123174893 cites W2124731827 @default.
- W2123174893 cites W2133663051 @default.
- W2123174893 cites W2136551429 @default.
- W2123174893 cites W2144892927 @default.
- W2123174893 cites W2145943989 @default.
- W2123174893 cites W2152568411 @default.
- W2123174893 cites W2154410058 @default.
- W2123174893 cites W2159712152 @default.
- W2123174893 cites W2163895770 @default.
- W2123174893 cites W2165628973 @default.
- W2123174893 doi "https://doi.org/10.1016/j.bbamem.2008.10.014" @default.
- W2123174893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19026610" @default.
- W2123174893 hasPublicationYear "2009" @default.
- W2123174893 type Work @default.
- W2123174893 sameAs 2123174893 @default.
- W2123174893 citedByCount "6" @default.
- W2123174893 countsByYear W21231748932015 @default.
- W2123174893 countsByYear W21231748932016 @default.
- W2123174893 countsByYear W21231748932020 @default.
- W2123174893 countsByYear W21231748932022 @default.
- W2123174893 crossrefType "journal-article" @default.
- W2123174893 hasAuthorship W2123174893A5030833355 @default.
- W2123174893 hasAuthorship W2123174893A5060650751 @default.
- W2123174893 hasAuthorship W2123174893A5063152845 @default.
- W2123174893 hasAuthorship W2123174893A5072509384 @default.
- W2123174893 hasAuthorship W2123174893A5082063349 @default.
- W2123174893 hasAuthorship W2123174893A5086985368 @default.
- W2123174893 hasBestOaLocation W21231748932 @default.
- W2123174893 hasConcept C103038307 @default.
- W2123174893 hasConcept C108625454 @default.
- W2123174893 hasConcept C12554922 @default.
- W2123174893 hasConcept C130316041 @default.
- W2123174893 hasConcept C159047783 @default.
- W2123174893 hasConcept C185154212 @default.
- W2123174893 hasConcept C185592680 @default.
- W2123174893 hasConcept C192157962 @default.
- W2123174893 hasConcept C2522874641 @default.
- W2123174893 hasConcept C2777339483 @default.
- W2123174893 hasConcept C2778918659 @default.
- W2123174893 hasConcept C2780593183 @default.
- W2123174893 hasConcept C39944091 @default.
- W2123174893 hasConcept C41625074 @default.
- W2123174893 hasConcept C55493867 @default.
- W2123174893 hasConcept C86803240 @default.
- W2123174893 hasConcept C95444343 @default.
- W2123174893 hasConcept C97380033 @default.
- W2123174893 hasConceptScore W2123174893C103038307 @default.
- W2123174893 hasConceptScore W2123174893C108625454 @default.
- W2123174893 hasConceptScore W2123174893C12554922 @default.
- W2123174893 hasConceptScore W2123174893C130316041 @default.
- W2123174893 hasConceptScore W2123174893C159047783 @default.
- W2123174893 hasConceptScore W2123174893C185154212 @default.
- W2123174893 hasConceptScore W2123174893C185592680 @default.