Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123176873> ?p ?o ?g. }
- W2123176873 endingPage "1392" @default.
- W2123176873 startingPage "1382" @default.
- W2123176873 abstract "Cytomegalovirus (CMV) infection directly targets vascular endothelium and smooth muscle and at older ages is associated with accelerated vascular pathology and mortality. CMV-specific cellular immunity might directly contribute to this process. Conventional ex vivo activation-induced T-cell responses to 19 dominant CMV antigens, along with CMV-specific inducible regulatory-type CD4+ T cells (iTregs), were measured in healthy older people, using a novel protocol that included classic Treg markers alongside the activation marker CD134. Measurements were correlated with diastolic, systolic, and mean arterial blood pressure, a surrogate marker for arterial stiffness. CMV-specific iTregs recognized the same antigens as conventional CD4+ T cells and were significantly more frequent at older ages. They suppressed antigen-specific and nonspecific proliferation and in large part expressed Foxp3. Frequencies of CMV-specific iTregs and CD8+ T cells (summated response) were significantly associated with diastolic and mean arterial pressures. Confounders, including age, body mass index, smoking, antihypertensive medication use, or C-reactive protein levels, did not explain these observations. A novel CMV-induced regulatory-type CD4+ T-cell subset is readily detectable in CMV-infected people and, like the aggregate CD8+ T-cell response to the most dominant CMV antigens, is quantitatively associated with arterial stiffness in older life. Whereas CD8+ effector T cells might directly cause vascular injury, iTregs may attenuate this response." @default.
- W2123176873 created "2016-06-24" @default.
- W2123176873 creator A5001836884 @default.
- W2123176873 creator A5003820675 @default.
- W2123176873 creator A5010362194 @default.
- W2123176873 creator A5033267681 @default.
- W2123176873 creator A5035617308 @default.
- W2123176873 creator A5048429513 @default.
- W2123176873 creator A5050731847 @default.
- W2123176873 creator A5072687953 @default.
- W2123176873 date "2013-11-07" @default.
- W2123176873 modified "2023-10-17" @default.
- W2123176873 title "A Novel Cytomegalovirus-Induced Regulatory-Type T-Cell Subset Increases in Size During Older Life and Links Virus-Specific Immunity to Vascular Pathology" @default.
- W2123176873 cites W1553612782 @default.
- W2123176873 cites W1820160132 @default.
- W2123176873 cites W1971842136 @default.
- W2123176873 cites W1983990357 @default.
- W2123176873 cites W1984176331 @default.
- W2123176873 cites W1986151024 @default.
- W2123176873 cites W2008808301 @default.
- W2123176873 cites W2009098629 @default.
- W2123176873 cites W2009474250 @default.
- W2123176873 cites W2011490846 @default.
- W2123176873 cites W2012482638 @default.
- W2123176873 cites W2020381478 @default.
- W2123176873 cites W2027211040 @default.
- W2123176873 cites W2034787614 @default.
- W2123176873 cites W2050245631 @default.
- W2123176873 cites W2053763669 @default.
- W2123176873 cites W2072853625 @default.
- W2123176873 cites W2076291243 @default.
- W2123176873 cites W2085262683 @default.
- W2123176873 cites W2088519495 @default.
- W2123176873 cites W2096309022 @default.
- W2123176873 cites W2096736732 @default.
- W2123176873 cites W2097679000 @default.
- W2123176873 cites W2103291317 @default.
- W2123176873 cites W2103849595 @default.
- W2123176873 cites W2104996267 @default.
- W2123176873 cites W2106190040 @default.
- W2123176873 cites W2109392578 @default.
- W2123176873 cites W2110709781 @default.
- W2123176873 cites W2115027745 @default.
- W2123176873 cites W2120402501 @default.
- W2123176873 cites W2132466754 @default.
- W2123176873 cites W2136616293 @default.
- W2123176873 cites W2158109120 @default.
- W2123176873 cites W2158247368 @default.
- W2123176873 cites W2167842251 @default.
- W2123176873 cites W2168094636 @default.
- W2123176873 cites W2170007827 @default.
- W2123176873 doi "https://doi.org/10.1093/infdis/jit576" @default.
- W2123176873 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3982844" @default.
- W2123176873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24203779" @default.
- W2123176873 hasPublicationYear "2013" @default.
- W2123176873 type Work @default.
- W2123176873 sameAs 2123176873 @default.
- W2123176873 citedByCount "36" @default.
- W2123176873 countsByYear W21231768732014 @default.
- W2123176873 countsByYear W21231768732015 @default.
- W2123176873 countsByYear W21231768732016 @default.
- W2123176873 countsByYear W21231768732017 @default.
- W2123176873 countsByYear W21231768732018 @default.
- W2123176873 countsByYear W21231768732019 @default.
- W2123176873 countsByYear W21231768732020 @default.
- W2123176873 countsByYear W21231768732021 @default.
- W2123176873 countsByYear W21231768732022 @default.
- W2123176873 countsByYear W21231768732023 @default.
- W2123176873 crossrefType "journal-article" @default.
- W2123176873 hasAuthorship W2123176873A5001836884 @default.
- W2123176873 hasAuthorship W2123176873A5003820675 @default.
- W2123176873 hasAuthorship W2123176873A5010362194 @default.
- W2123176873 hasAuthorship W2123176873A5033267681 @default.
- W2123176873 hasAuthorship W2123176873A5035617308 @default.
- W2123176873 hasAuthorship W2123176873A5048429513 @default.
- W2123176873 hasAuthorship W2123176873A5050731847 @default.
- W2123176873 hasAuthorship W2123176873A5072687953 @default.
- W2123176873 hasBestOaLocation W21231768731 @default.
- W2123176873 hasConcept C147483822 @default.
- W2123176873 hasConcept C154317977 @default.
- W2123176873 hasConcept C167672396 @default.
- W2123176873 hasConcept C202751555 @default.
- W2123176873 hasConcept C203014093 @default.
- W2123176873 hasConcept C2776090121 @default.
- W2123176873 hasConcept C2779341262 @default.
- W2123176873 hasConcept C2779727006 @default.
- W2123176873 hasConcept C3017875465 @default.
- W2123176873 hasConcept C55493867 @default.
- W2123176873 hasConcept C71924100 @default.
- W2123176873 hasConcept C86803240 @default.
- W2123176873 hasConcept C8891405 @default.
- W2123176873 hasConceptScore W2123176873C147483822 @default.
- W2123176873 hasConceptScore W2123176873C154317977 @default.
- W2123176873 hasConceptScore W2123176873C167672396 @default.
- W2123176873 hasConceptScore W2123176873C202751555 @default.
- W2123176873 hasConceptScore W2123176873C203014093 @default.
- W2123176873 hasConceptScore W2123176873C2776090121 @default.
- W2123176873 hasConceptScore W2123176873C2779341262 @default.