FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123177072> ?p ?o ?g. }

• W2123177072 endingPage "595" @default.
• W2123177072 startingPage "588" @default.
• W2123177072 abstract "Mouse myocyte contractility and the changes induced by pressure overload are not fully understood. We studied contractile reserve in isolated left ventricular myocytes from mice with ascending aortic stenosis (AS) during compensatory hypertrophy (4-week AS) and the later stage of early failure (7-week AS) and from control mice. Myocyte contraction and [Ca(2+)](i) transients with fluo-3 were measured simultaneously. At baseline (0.5 Hz, 1.5 mmol/L [Ca(2+)](o), 25 degrees C), the amplitude of myocyte shortening and peak-systolic [Ca(2+)](i) in 7-week AS were not different from those of controls, whereas contraction, relaxation, and the decline of [Ca(2+)](i) transients were slower. In response to the challenge of high [Ca(2+)](o), fractional cell shortening was severely depressed with reduced peak-systolic [Ca(2+)](i) in 7-week AS compared with controls. In response to rapid pacing stimulation, cell shortening and peak-systolic [Ca(2+)](i) increased in controls, but this response was depressed in 7-week AS. In contrast, the responses to both challenge with high [Ca(2+)](o) and rapid pacing in 4-week AS were similar to those of controls. Although protein levels of Na(+)-Ca(2+) exchanger were increased in both 4-week and 7-week AS, the ratio of SR Ca(2+)-ATPase to phospholamban protein levels was depressed in 7-week AS compared with controls but not in 4-week AS. This was associated with an impaired capacity to increase sarcoplasmic reticulum Ca(2+) load during high work states in 7-week AS myocytes. In hypertrophied failing mouse myocytes, depressed contractile reserve is related to an impaired augmentation of systolic [Ca(2+)](i) and SR Ca(2+) load and simulates findings in human failing myocytes." @default.
• W2123177072 created "2016-06-24" @default.
• W2123177072 creator A5006718419 @default.
• W2123177072 creator A5010550624 @default.
• W2123177072 creator A5013469439 @default.
• W2123177072 creator A5019054175 @default.
• W2123177072 creator A5029121602 @default.
• W2123177072 creator A5085665354 @default.
• W2123177072 date "2000-09-29" @default.
• W2123177072 modified "2023-10-17" @default.
• W2123177072 title "Contractile Reserve and Intracellular Calcium Regulation in Mouse Myocytes From Normal and Hypertrophied Failing Hearts" @default.
• W2123177072 cites W1972134881 @default.
• W2123177072 cites W2007801010 @default.
• W2123177072 cites W2011637501 @default.
• W2123177072 cites W2014501709 @default.
• W2123177072 cites W2022109153 @default.
• W2123177072 cites W2027162244 @default.
• W2123177072 cites W2027204345 @default.
• W2123177072 cites W2036424054 @default.
• W2123177072 cites W2042646075 @default.
• W2123177072 cites W2087186577 @default.
• W2123177072 cites W2089412926 @default.
• W2123177072 cites W2090630705 @default.
• W2123177072 cites W2106377610 @default.
• W2123177072 cites W2172519975 @default.
• W2123177072 cites W2176715668 @default.
• W2123177072 cites W2286417340 @default.
• W2123177072 cites W2306496033 @default.
• W2123177072 cites W2309341672 @default.
• W2123177072 cites W2407259462 @default.
• W2123177072 cites W2413689718 @default.
• W2123177072 doi "https://doi.org/10.1161/01.res.87.7.588" @default.
• W2123177072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11009564" @default.
• W2123177072 hasPublicationYear "2000" @default.
• W2123177072 type Work @default.
• W2123177072 sameAs 2123177072 @default.
• W2123177072 citedByCount "75" @default.
• W2123177072 countsByYear W21231770722012 @default.
• W2123177072 countsByYear W21231770722013 @default.
• W2123177072 countsByYear W21231770722014 @default.
• W2123177072 countsByYear W21231770722015 @default.
• W2123177072 countsByYear W21231770722016 @default.
• W2123177072 countsByYear W21231770722020 @default.
• W2123177072 countsByYear W21231770722022 @default.
• W2123177072 countsByYear W21231770722023 @default.
• W2123177072 crossrefType "journal-article" @default.
• W2123177072 hasAuthorship W2123177072A5006718419 @default.
• W2123177072 hasAuthorship W2123177072A5010550624 @default.
• W2123177072 hasAuthorship W2123177072A5013469439 @default.
• W2123177072 hasAuthorship W2123177072A5019054175 @default.
• W2123177072 hasAuthorship W2123177072A5029121602 @default.
• W2123177072 hasAuthorship W2123177072A5085665354 @default.
• W2123177072 hasBestOaLocation W21231770721 @default.
• W2123177072 hasConcept C126322002 @default.
• W2123177072 hasConcept C134018914 @default.
• W2123177072 hasConcept C158617107 @default.
• W2123177072 hasConcept C163415756 @default.
• W2123177072 hasConcept C167414201 @default.
• W2123177072 hasConcept C17137333 @default.
• W2123177072 hasConcept C185592680 @default.
• W2123177072 hasConcept C207200792 @default.
• W2123177072 hasConcept C2778198053 @default.
• W2123177072 hasConcept C2778271984 @default.
• W2123177072 hasConcept C3018791406 @default.
• W2123177072 hasConcept C39133596 @default.
• W2123177072 hasConcept C519063684 @default.
• W2123177072 hasConcept C55493867 @default.
• W2123177072 hasConcept C71924100 @default.
• W2123177072 hasConcept C86803240 @default.
• W2123177072 hasConceptScore W2123177072C126322002 @default.
• W2123177072 hasConceptScore W2123177072C134018914 @default.
• W2123177072 hasConceptScore W2123177072C158617107 @default.
• W2123177072 hasConceptScore W2123177072C163415756 @default.
• W2123177072 hasConceptScore W2123177072C167414201 @default.
• W2123177072 hasConceptScore W2123177072C17137333 @default.
• W2123177072 hasConceptScore W2123177072C185592680 @default.
• W2123177072 hasConceptScore W2123177072C207200792 @default.
• W2123177072 hasConceptScore W2123177072C2778198053 @default.
• W2123177072 hasConceptScore W2123177072C2778271984 @default.
• W2123177072 hasConceptScore W2123177072C3018791406 @default.
• W2123177072 hasConceptScore W2123177072C39133596 @default.
• W2123177072 hasConceptScore W2123177072C519063684 @default.
• W2123177072 hasConceptScore W2123177072C55493867 @default.
• W2123177072 hasConceptScore W2123177072C71924100 @default.
• W2123177072 hasConceptScore W2123177072C86803240 @default.
• W2123177072 hasIssue "7" @default.
• W2123177072 hasLocation W21231770721 @default.
• W2123177072 hasLocation W21231770722 @default.
• W2123177072 hasOpenAccess W2123177072 @default.
• W2123177072 hasPrimaryLocation W21231770721 @default.
• W2123177072 hasRelatedWork W2003842308 @default.
• W2123177072 hasRelatedWork W2004786427 @default.
• W2123177072 hasRelatedWork W2012616967 @default.
• W2123177072 hasRelatedWork W2064236298 @default.
• W2123177072 hasRelatedWork W2095093072 @default.
• W2123177072 hasRelatedWork W2106040905 @default.
• W2123177072 hasRelatedWork W2123177072 @default.
• W2123177072 hasRelatedWork W2123216038 @default.

• next