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• W2123193762 endingPage "H1456" @default.
• W2123193762 startingPage "H1446" @default.
• W2123193762 abstract "The aim of this study was to investigate the tolerance of failing myocardium from postinfarction rats to simulated ischemia. Myocardial infarction (MI) was induced by ligation of the left coronary artery in male Wistar rats. Isometric force and free intracellular Ca(2+) concentration ([Ca(2+)](i)) were measured in isolated left ventricular papillary muscles from sham-operated and post-MI animals 6 wk after surgery. Ischemia was simulated by using fluorocarbon immersion with hypoxia. Results showed that mechanical performance was depressed during the period of hypoxia in physiological salt solution (44 +/- 7% of baseline in sham vs. 30 +/- 6% of baseline in MI, P < 0.05) or ischemia (16 +/- 2% of baseline in sham vs. 9 +/- 1% of baseline in MI, P < 0.01) accompanied by no corresponding decrease of peak [Ca(2+)](i) (hypoxia: 51 +/- 8% of baseline in sham vs. 46 +/- 7% of baseline in MI, P = NS; ischemia: 47 +/- 5% of baseline in sham, 39 +/- 7% of baseline in MI, P = NS). After reoxygenation, [Ca(2+)](i) rapidly returned to near preischemic basal levels, whereas developed tension in fluorocarbon remained significantly lower. This dissociation between peak [Ca(2+)](i) and isometric contractility was more pronounced in the failing myocardium from postinfarction rats. In conclusion, more severe impairment of [Ca(2+)](i) homeostasis in the failing myocardium from postinfarction rats increases susceptibility to ischemia-reperfusion injury." @default.
• W2123193762 created "2016-06-24" @default.
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• W2123193762 date "2000-05-01" @default.
• W2123193762 modified "2023-09-25" @default.
• W2123193762 title "Depressed tolerance to fluorocarbon-simulated ischemia in failing myocardium due to impaired [Ca²⁺]_imodulation" @default.
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• W2123193762 doi "https://doi.org/10.1152/ajpheart.2000.278.5.h1446" @default.
• W2123193762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10775121" @default.
• W2123193762 hasPublicationYear "2000" @default.
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