FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123201636> ?p ?o ?g. }

• W2123201636 endingPage "17477" @default.
• W2123201636 startingPage "17474" @default.
• W2123201636 abstract "High-affinity binding of thyroid hormone (T3) to nuclear receptors influences the transcriptional rate of specific genes. The carboxylic acid, sodium butyrate, is known to reduce nuclear binding of T3 in GH3 rat pituitary cels, and this effect correlates with inhibition of T3 responsiveness. Incubation of GH3 cells with 10 mM, but not 1 mM, sodium butyrate abolishes induction of growth hormone gene expression by T3. The relationship between thyroid hormone receptor (TR) depletion and inhibition of T3 action was further investigated by determining the effects of sodium butyrate on TR gene expression. GH3 cells contain mRNAs encoding at least three thyroid hormone receptors (TRs alpha 1, beta 1, and beta 2), as well as a related non-T3 binding repressor or T3 action (c-erbA alpha 2). Remarkably, 10 mM sodium butyrate reduces TR beta 2 mRNA levels by greater than 95% in the presence or absence of T3. The down-regulation of TR beta 2 mRNA occurs at a concentration of sodium butyrate between 5 and 10 mM and is maximal by 8 h of treatment. In contrast, TR beta 1 mRNA levels are unchanged. Furthermore, sodium butyrate has little effect on the mRNAs encoding TR alpha 1 and c-erbA alpha 2. Nuclear run-on assays indicated that sodium butyrate depletes TR beta 2 mRNA by rapidly repressing TR beta 2 gene transcription. In the presence of the transcriptional inhibitor, actinomycin D, the half-life of TR beta 2 mRNA was approximately 3 h in the presence or absence of sodium butyrate. Thus, the reduction in TR number induced by sodium butyrate is likely to be due to the transcriptionally mediated reduction in TR beta 2 mRNA. These data suggest that TR beta 2 has an important physiological role in the regulation of growth hormone gene expression by T3." @default.
• W2123201636 created "2016-06-24" @default.
• W2123201636 creator A5075882004 @default.
• W2123201636 date "1990-10-01" @default.
• W2123201636 modified "2023-10-15" @default.
• W2123201636 title "Sodium butyrate selectively alters thyroid hormone receptor gene expression in GH3 cells." @default.
• W2123201636 cites W123333279 @default.
• W2123201636 cites W140087283 @default.
• W2123201636 cites W1532040890 @default.
• W2123201636 cites W1537146606 @default.
• W2123201636 cites W1565777341 @default.
• W2123201636 cites W1568323065 @default.
• W2123201636 cites W1606138580 @default.
• W2123201636 cites W1670076014 @default.
• W2123201636 cites W1911488345 @default.
• W2123201636 cites W1933411091 @default.
• W2123201636 cites W1965735992 @default.
• W2123201636 cites W1971263640 @default.
• W2123201636 cites W1974639601 @default.
• W2123201636 cites W1975671933 @default.
• W2123201636 cites W1979544459 @default.
• W2123201636 cites W1982588581 @default.
• W2123201636 cites W1983450433 @default.
• W2123201636 cites W1987284343 @default.
• W2123201636 cites W1994987671 @default.
• W2123201636 cites W1995436294 @default.
• W2123201636 cites W1997514802 @default.
• W2123201636 cites W2021253208 @default.
• W2123201636 cites W2023947174 @default.
• W2123201636 cites W2028549678 @default.
• W2123201636 cites W2040916062 @default.
• W2123201636 cites W2050874067 @default.
• W2123201636 cites W2058232931 @default.
• W2123201636 cites W2060333964 @default.
• W2123201636 cites W2077580619 @default.
• W2123201636 cites W2080046379 @default.
• W2123201636 cites W2082538115 @default.
• W2123201636 cites W2083432935 @default.
• W2123201636 cites W2085124463 @default.
• W2123201636 cites W2089052831 @default.
• W2123201636 cites W2089264059 @default.
• W2123201636 cites W2090024435 @default.
• W2123201636 cites W2100805638 @default.
• W2123201636 cites W2119671728 @default.
• W2123201636 cites W2131695882 @default.
• W2123201636 cites W2166401623 @default.
• W2123201636 cites W2171315857 @default.
• W2123201636 cites W2419377870 @default.
• W2123201636 doi "https://doi.org/10.1016/s0021-9258(18)38188-2" @default.
• W2123201636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2211641" @default.
• W2123201636 hasPublicationYear "1990" @default.
• W2123201636 type Work @default.
• W2123201636 sameAs 2123201636 @default.
• W2123201636 citedByCount "47" @default.
• W2123201636 countsByYear W21232016362012 @default.
• W2123201636 countsByYear W21232016362013 @default.
• W2123201636 countsByYear W21232016362014 @default.
• W2123201636 countsByYear W21232016362019 @default.
• W2123201636 countsByYear W21232016362021 @default.
• W2123201636 crossrefType "journal-article" @default.
• W2123201636 hasAuthorship W2123201636A5075882004 @default.
• W2123201636 hasBestOaLocation W21232016361 @default.
• W2123201636 hasConcept C104317684 @default.
• W2123201636 hasConcept C109115496 @default.
• W2123201636 hasConcept C121608353 @default.
• W2123201636 hasConcept C126322002 @default.
• W2123201636 hasConcept C133603901 @default.
• W2123201636 hasConcept C134018914 @default.
• W2123201636 hasConcept C150194340 @default.
• W2123201636 hasConcept C170493617 @default.
• W2123201636 hasConcept C185592680 @default.
• W2123201636 hasConcept C23589133 @default.
• W2123201636 hasConcept C2778942008 @default.
• W2123201636 hasConcept C526584372 @default.
• W2123201636 hasConcept C530470458 @default.
• W2123201636 hasConcept C55493867 @default.
• W2123201636 hasConcept C71315377 @default.
• W2123201636 hasConcept C71924100 @default.
• W2123201636 hasConcept C86803240 @default.
• W2123201636 hasConcept C95444343 @default.
• W2123201636 hasConceptScore W2123201636C104317684 @default.
• W2123201636 hasConceptScore W2123201636C109115496 @default.
• W2123201636 hasConceptScore W2123201636C121608353 @default.
• W2123201636 hasConceptScore W2123201636C126322002 @default.
• W2123201636 hasConceptScore W2123201636C133603901 @default.
• W2123201636 hasConceptScore W2123201636C134018914 @default.
• W2123201636 hasConceptScore W2123201636C150194340 @default.
• W2123201636 hasConceptScore W2123201636C170493617 @default.
• W2123201636 hasConceptScore W2123201636C185592680 @default.
• W2123201636 hasConceptScore W2123201636C23589133 @default.
• W2123201636 hasConceptScore W2123201636C2778942008 @default.
• W2123201636 hasConceptScore W2123201636C526584372 @default.
• W2123201636 hasConceptScore W2123201636C530470458 @default.
• W2123201636 hasConceptScore W2123201636C55493867 @default.
• W2123201636 hasConceptScore W2123201636C71315377 @default.
• W2123201636 hasConceptScore W2123201636C71924100 @default.
• W2123201636 hasConceptScore W2123201636C86803240 @default.
• W2123201636 hasConceptScore W2123201636C95444343 @default.

• next