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• W2123202877 abstract "Laboratory RNA structure determination is demanding and costly and thus, computational structure prediction is an important task. Single sequence methods for RNA secondary structure prediction are limited by the accuracy of the underlying folding model, if a structure is supported by a family of evolutionarily related sequences, one can be more confident that the prediction is accurate. RNA pseudoknots are functional elements, which have highly conserved structures. However, few comparative structure prediction methods can handle pseudoknots due to the computational complexity.A comparative pseudoknot prediction method called DotKnot-PW is introduced based on structural comparison of secondary structure elements and H-type pseudoknot candidates. DotKnot-PW outperforms other methods from the literature on a hand-curated test set of RNA structures with experimental support.DotKnot-PW and the RNA structure test set are available at the web site http://dotknot.csse.uwa.edu.au/pw.janaspe@csse.uwa.edu.auSupplementary data are available at Bioinformatics online." @default.
• W2123202877 created "2016-06-24" @default.
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• W2123202877 date "2012-10-08" @default.
• W2123202877 modified "2023-09-23" @default.
• W2123202877 title "Predicting pseudoknotted structures across two RNA sequences" @default.
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• W2123202877 doi "https://doi.org/10.1093/bioinformatics/bts575" @default.
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