Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123204955> ?p ?o ?g. }
- W2123204955 abstract "Air pollution exposures are linked to systemic inflammation, cardiovascular and respiratory morbidity and mortality, neuroinflammation and neuropathology in young urbanites. In particular, most Mexico City Metropolitan Area (MCMA) children exhibit subtle cognitive deficits, and neuropathology studies show 40% of them exhibiting frontal tau hyperphosphorylation and 51% amyloid-β diffuse plaques (compared to 0% in low pollution control children). We assessed whether a short cocoa intervention can be effective in decreasing plasma endothelin 1 (ET-1) and/or inflammatory mediators in MCMA children. Thirty gram of dark cocoa with 680 mg of total flavonols were given daily for 10.11 ± 3.4 days (range 9-24 days) to 18 children (10.55 years, SD = 1.45; 11F/7M). Key metabolite ratios in frontal white matter and in hippocampus pre and during cocoa intervention were quantified by magnetic resonance spectroscopy. ET-1 significantly decreased after cocoa treatment (p = 0.0002). Fifteen children (83%) showed a marginally significant individual improvement in one or both of the applied simple short memory tasks. Endothelial dysfunction is a key feature of exposure to particulate matter (PM) and decreased endothelin-1 bioavailability is likely useful for brain function in the context of air pollution. Our findings suggest that cocoa interventions may be critical for early implementation of neuroprotection of highly exposed urban children. Multi-domain nutraceutical interventions could limit the risk for endothelial dysfunction, cerebral hypoperfusion, neuroinflammation, cognitive deficits, structural volumetric detrimental brain effects, and the early development of the neuropathological hallmarks of Alzheimer's and Parkinson's diseases." @default.
- W2123204955 created "2016-06-24" @default.
- W2123204955 creator A5001395031 @default.
- W2123204955 creator A5003718052 @default.
- W2123204955 creator A5007804591 @default.
- W2123204955 creator A5012882360 @default.
- W2123204955 creator A5017464998 @default.
- W2123204955 creator A5036064445 @default.
- W2123204955 creator A5039582984 @default.
- W2123204955 creator A5049958295 @default.
- W2123204955 creator A5063027189 @default.
- W2123204955 creator A5063309068 @default.
- W2123204955 creator A5068837856 @default.
- W2123204955 creator A5072706793 @default.
- W2123204955 creator A5077961759 @default.
- W2123204955 creator A5087484202 @default.
- W2123204955 creator A5091750420 @default.
- W2123204955 creator A5091765639 @default.
- W2123204955 date "2013-01-01" @default.
- W2123204955 modified "2023-09-26" @default.
- W2123204955 title "Flavonol-rich dark cocoa significantly decreases plasma endothelin-1 and improves cognition in urban children" @default.
- W2123204955 cites W1509349980 @default.
- W2123204955 cites W1571725385 @default.
- W2123204955 cites W171156348 @default.
- W2123204955 cites W1964607146 @default.
- W2123204955 cites W1964861389 @default.
- W2123204955 cites W1968921200 @default.
- W2123204955 cites W1973893370 @default.
- W2123204955 cites W1977340798 @default.
- W2123204955 cites W1978522885 @default.
- W2123204955 cites W1979096652 @default.
- W2123204955 cites W1986279294 @default.
- W2123204955 cites W1988401581 @default.
- W2123204955 cites W1990362540 @default.
- W2123204955 cites W2000424893 @default.
- W2123204955 cites W2008624929 @default.
- W2123204955 cites W2008788704 @default.
- W2123204955 cites W2012874600 @default.
- W2123204955 cites W2012973600 @default.
- W2123204955 cites W2014105038 @default.
- W2123204955 cites W2015983038 @default.
- W2123204955 cites W2016517325 @default.
- W2123204955 cites W2017887957 @default.
- W2123204955 cites W2019806189 @default.
- W2123204955 cites W2022392583 @default.
- W2123204955 cites W2022588686 @default.
- W2123204955 cites W2027783468 @default.
- W2123204955 cites W2028544693 @default.
- W2123204955 cites W2031447950 @default.
- W2123204955 cites W2034142305 @default.
- W2123204955 cites W2035605584 @default.
- W2123204955 cites W2037569292 @default.
- W2123204955 cites W2040408686 @default.
- W2123204955 cites W2041376120 @default.
- W2123204955 cites W2048986120 @default.
- W2123204955 cites W2049156026 @default.
- W2123204955 cites W2049521111 @default.
- W2123204955 cites W2049685220 @default.
- W2123204955 cites W2051173316 @default.
- W2123204955 cites W2051421916 @default.
- W2123204955 cites W2053418060 @default.
- W2123204955 cites W2054398897 @default.
- W2123204955 cites W2055750901 @default.
- W2123204955 cites W2057463858 @default.
- W2123204955 cites W2058567239 @default.
- W2123204955 cites W2058743295 @default.
- W2123204955 cites W2062065980 @default.
- W2123204955 cites W2062934118 @default.
- W2123204955 cites W2063169512 @default.
- W2123204955 cites W2071956136 @default.
- W2123204955 cites W2076212455 @default.
- W2123204955 cites W2077264199 @default.
- W2123204955 cites W2078706344 @default.
- W2123204955 cites W2081066822 @default.
- W2123204955 cites W2081674453 @default.
- W2123204955 cites W2082235350 @default.
- W2123204955 cites W2085237061 @default.
- W2123204955 cites W2086504454 @default.
- W2123204955 cites W2089179540 @default.
- W2123204955 cites W2089851064 @default.
- W2123204955 cites W2090378728 @default.
- W2123204955 cites W2092656162 @default.
- W2123204955 cites W2094807620 @default.
- W2123204955 cites W2097844974 @default.
- W2123204955 cites W2098143618 @default.
- W2123204955 cites W2099301235 @default.
- W2123204955 cites W2110589919 @default.
- W2123204955 cites W2111120834 @default.
- W2123204955 cites W2111283187 @default.
- W2123204955 cites W2112332330 @default.
- W2123204955 cites W2119538739 @default.
- W2123204955 cites W2120588984 @default.
- W2123204955 cites W2124218528 @default.
- W2123204955 cites W2125087765 @default.
- W2123204955 cites W2127435517 @default.
- W2123204955 cites W2128936731 @default.
- W2123204955 cites W2131043924 @default.
- W2123204955 cites W2135357859 @default.
- W2123204955 cites W2135685983 @default.
- W2123204955 cites W2136898871 @default.