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• W2123216891 endingPage "1362" @default.
• W2123216891 startingPage "1351" @default.
• W2123216891 abstract "The mitochondrial protein frataxin helps maintain appropriate iron levels in the mitochondria of yeast and humans. A deficiency of this protein in humans causes Friedreich's ataxia, while its complete absence in yeast (Delta yfh1 mutant) results in loss of mitochondrial DNA, apparently due to radicals generated by excess iron. We found that the absence of frataxin in yeast also leads to nuclear damage, as evidenced by inducibility of a nuclear DNA damage reporter, increased chromosomal instability including recombination and mutation, and greater sensitivity to DNA-damaging agents, as well as slow growth. Addition of a human frataxin mutant did not prevent nuclear damage, although it partially complemented the Delta yfh1 mutant in preventing mitochondrial DNA loss. The effects in Delta yfh1 mutants result from reactive oxygen species (ROS), since (i) Delta yfh1 cells produce more hydrogen peroxide, (ii) the effects are alleviated by a radical scavenger and (iii) the glutathione peroxidase gene prevents an increase in mutation rates. Thus, the frataxin protein is concluded to have a protective role for the nucleus as well as the mitochondria." @default.
• W2123216891 created "2016-06-24" @default.
• W2123216891 creator A5035521745 @default.
• W2123216891 date "2002-05-16" @default.
• W2123216891 modified "2023-10-14" @default.
• W2123216891 title "The mitochondrial protein frataxin prevents nuclear damage" @default.
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• W2123216891 doi "https://doi.org/10.1093/hmg/11.11.1351" @default.
• W2123216891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12019217" @default.
• W2123216891 hasPublicationYear "2002" @default.
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