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- W2123221500 abstract "The optimal composition of dietary lipids in the neonatal period is of growing interest because of their importance for the development and function of neural tissue. However, little is known about fat digestion in infancy. Stable isotope (13C) labelled mixed triacylglycerol has been used to measure functional fat digestion in adults and children with cystic fibrosis. Using this method, we tested the hypothesis that fat digestion is immature at birth but develops rapidly to normal levels during the first year of life. 32 tests were performed (18 on neonates aged 1-6 days, 5 at age 7-21 days and 9 at 57-447 days). Results were expressed as percentage dose of 13C recovered (PDR) in each 30 minute interval, and cumulative PDR (cPDR) against time after ingestion of the substrate. From the graphs, peak PDR, cPDR at peak, cPDR at 360 mins, and time to peak were measured and expressed as mean (SEM). Table There was a significant difference between the youngest and oldest age group in cPDR at 360 mins (p=0.003) and peak PDR (p=0.004), but the difference in cPDR at peak was just outside significance (p=0.07) and there was no significant difference in time to peak (p=0.17). There was a significant rise in cPDR360 (p=0.003) and peak PDR (p=0.007) in four of the five babies in the middle age group who were tested before 6 days. These results show that the functional capacity of the newborn to digest fats is low at birth, but rises rapidly over the first few weeks of life to normal adult levels." @default.
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- W2123221500 date "1996-05-01" @default.
- W2123221500 modified "2023-09-27" @default.
- W2123221500 title "73 FUNCTIONAL CAPACITY OF THE NEWBORN TO DIGEST DIETARY FATS" @default.
- W2123221500 doi "https://doi.org/10.1097/00005176-199605000-00086" @default.
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