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• W2123229085 abstract "To evaluate the effects of liothyronine (3,5,3′-triiodo-l-thyronine, T 3 ) on Na + channel current ( I Na ) properties, I Na was recorded in adult guinea pig ventricular myocytes. T 3 (1 nM) acutely increased whole cell I Na and shifted the steady-state I Na inactivation curve dose dependently. When the pipette solution contained 100 μM GTP or GTPγS, the effect of T 3 on the whole cell I Na was increased two- to threefold. This effect was almost completely abolished by pertussis toxin preincubation. In the cell-attached patch, T 3 increased the open probability of single I Na by reducing the null probability. In the inside-out patch, T 3 effect was 10 times faster than that in whole cell and cell-attached patches while GTPγS was present and could be completely washed out. T 3 alone slightly increased the channel open probability by increasing the closed state to open state rate constant ( k CO ) and reducing the null probability. GTPγS exposure only increased the number of functional channels. T 3 and GTPγS synergistically enhanced the channel open probability 5.8 ± 0.5-fold by increasing k CO , decreasing the open state to absorbing inactivated state rate constant, and greatly reducing the null probability. These results demonstrate that T 3 acts on the cytosolic side of the membrane and acutely activates I Na . Pertussis toxin-sensitive G protein modulation greatly magnifies the T 3 effects on the channel kinetics and null probability, thereby increasing the channel open probability." @default.
• W2123229085 created "2016-06-24" @default.
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• W2123229085 date "2002-11-01" @default.
• W2123229085 modified "2023-09-26" @default.
• W2123229085 title "G protein modulates thyroid hormone-induced Na⁺ channel activation in ventricular myocytes" @default.
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• W2123229085 doi "https://doi.org/10.1152/ajpheart.00326.2002" @default.
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