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• W2123229384 abstract "Abstract A variety of ribonucleoprotein (RNP) granules form in eukaryotic cells to regulate the translation, decay, and localization of the encapsulated messenger RNA (mRNAs). The work here examined the assembly and function of two highly conserved RNP structures, the processing body (P body) and the stress granule, in the yeast Saccharomyces cerevisiae. These granules are induced by similar stress conditions and contain translationally repressed mRNAs and a partially overlapping set of protein constituents. However, despite these similarities, the data indicate that these RNP complexes are independently assembled and that this assembly is controlled by different signaling pathways. In particular, the cAMP-dependent protein kinase (PKA) was found to control P body formation under all conditions examined. In contrast, the assembly of stress granules was not affected by changes in either PKA or TORC1 signalling activity. Both of these RNP granules were also detected in stationary-phase cells, but each appears at a distinct time. P bodies were formed prior to stationary-phase arrest, and the data suggest that these foci are important for the long-term survival of these quiescent cells. Stress granules, on the other hand, were not assembled until after the cells had entered into the stationary phase of growth and their appearance could therefore serve as a specific marker for the entry into this quiescent state. In all, the results here provide a framework for understanding the assembly of these RNP complexes and suggest that these structures have distinct but important activities in quiescent cells." @default.
• W2123229384 created "2016-06-24" @default.
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• W2123229384 date "2013-01-01" @default.
• W2123229384 modified "2023-10-10" @default.
• W2123229384 title "Processing Body and Stress Granule Assembly Occur by Independent and Differentially Regulated Pathways in<i>Saccharomyces cerevisiae</i>" @default.
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• W2123229384 doi "https://doi.org/10.1534/genetics.112.146993" @default.
• W2123229384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3527240" @default.
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