Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123231730> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2123231730 endingPage "104" @default.
- W2123231730 startingPage "99" @default.
- W2123231730 abstract "Concurrent chemotherapy with daily thoracic radiation therapy is a common regimen used in patients with non-small cell lung cancer resulting in excellent response rates but with appreciable morbidity. Radiation-induced toxicities may increase the number of treatment breaks and then may limit the use of this aggressive treatment approach for some patients. We are conducting an open-label, multicenter trial determining the incidence of radiation treatment breaks and severity of treatment-related toxicities with the concurrent use of a cytoprotective agent. Approximately 15 to 20 sites in the United States will participate with a total of 200 patients. Patients will receive one of two chemotherapy regimens and daily radiation (1.8 to 2.0 Gy daily; total dose, 60 to 70 Gy) and amifostine 500 mg subcutaneously or intravenous push daily over a 6- to 7-week period. Patients will receive amifostine (Ethyol; MedImmune Inc, Gaithersburg, MD) 500 mg daily. The route of amifostine administration chosen at the time of patient registration must be adhered to throughout the study. In addition, all patients may receive consolidation chemotherapy consisting of intravenous docetaxel 75 mg/m 2 once every 3 weeks for three courses, starting more than 30 but less than 60 days after the last dose of amifostine or thoracic radiation therapy, whichever is the last therapy discontinued. The objectives of this study are to determine the incidence of radiation treatment breaks and evaluate acute radiation esophagitis, acute radiation pneumonitis, chronic radiation pneumonitis, and pulmonary function in patients with measurable, medically inoperable non-small cell lung cancer stage II, unresectable stage IIIA, or IIIB disease receiving combined modality therapy and amifostine." @default.
- W2123231730 created "2016-06-24" @default.
- W2123231730 creator A5015065013 @default.
- W2123231730 creator A5031260770 @default.
- W2123231730 date "2005-04-01" @default.
- W2123231730 modified "2023-10-18" @default.
- W2123231730 title "Reduction of Treatment Breaks and Radiation-Induced Esophagitis and Pneumonitis Using Amifostine in Unresectable Non-Small Cell Lung Cancer Patients Receiving Definitive Concurrent Chemotherapy and Radiation Therapy: A Prospective Community-Based Clinical Trial" @default.
- W2123231730 cites W1751540033 @default.
- W2123231730 cites W1894754434 @default.
- W2123231730 cites W1895775305 @default.
- W2123231730 cites W1964865644 @default.
- W2123231730 cites W1965920084 @default.
- W2123231730 cites W1986797683 @default.
- W2123231730 cites W2004520476 @default.
- W2123231730 cites W2005383143 @default.
- W2123231730 cites W2054395348 @default.
- W2123231730 cites W2068612483 @default.
- W2123231730 cites W2072993227 @default.
- W2123231730 cites W2461149817 @default.
- W2123231730 cites W4231647528 @default.
- W2123231730 cites W4234133678 @default.
- W2123231730 doi "https://doi.org/10.1053/j.seminoncol.2005.03.017" @default.
- W2123231730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16015543" @default.
- W2123231730 hasPublicationYear "2005" @default.
- W2123231730 type Work @default.
- W2123231730 sameAs 2123231730 @default.
- W2123231730 citedByCount "6" @default.
- W2123231730 countsByYear W21232317302012 @default.
- W2123231730 countsByYear W21232317302014 @default.
- W2123231730 countsByYear W21232317302018 @default.
- W2123231730 countsByYear W21232317302023 @default.
- W2123231730 crossrefType "journal-article" @default.
- W2123231730 hasAuthorship W2123231730A5015065013 @default.
- W2123231730 hasAuthorship W2123231730A5031260770 @default.
- W2123231730 hasConcept C126322002 @default.
- W2123231730 hasConcept C141071460 @default.
- W2123231730 hasConcept C2776256026 @default.
- W2123231730 hasConcept C2776694085 @default.
- W2123231730 hasConcept C2777714996 @default.
- W2123231730 hasConcept C2779134260 @default.
- W2123231730 hasConcept C2779387952 @default.
- W2123231730 hasConcept C2779524853 @default.
- W2123231730 hasConcept C2779920096 @default.
- W2123231730 hasConcept C2781190966 @default.
- W2123231730 hasConcept C2781413609 @default.
- W2123231730 hasConcept C43270747 @default.
- W2123231730 hasConcept C509974204 @default.
- W2123231730 hasConcept C71924100 @default.
- W2123231730 hasConceptScore W2123231730C126322002 @default.
- W2123231730 hasConceptScore W2123231730C141071460 @default.
- W2123231730 hasConceptScore W2123231730C2776256026 @default.
- W2123231730 hasConceptScore W2123231730C2776694085 @default.
- W2123231730 hasConceptScore W2123231730C2777714996 @default.
- W2123231730 hasConceptScore W2123231730C2779134260 @default.
- W2123231730 hasConceptScore W2123231730C2779387952 @default.
- W2123231730 hasConceptScore W2123231730C2779524853 @default.
- W2123231730 hasConceptScore W2123231730C2779920096 @default.
- W2123231730 hasConceptScore W2123231730C2781190966 @default.
- W2123231730 hasConceptScore W2123231730C2781413609 @default.
- W2123231730 hasConceptScore W2123231730C43270747 @default.
- W2123231730 hasConceptScore W2123231730C509974204 @default.
- W2123231730 hasConceptScore W2123231730C71924100 @default.
- W2123231730 hasLocation W21232317301 @default.
- W2123231730 hasLocation W21232317302 @default.
- W2123231730 hasOpenAccess W2123231730 @default.
- W2123231730 hasPrimaryLocation W21232317301 @default.
- W2123231730 hasRelatedWork W2120295836 @default.
- W2123231730 hasRelatedWork W2355231058 @default.
- W2123231730 hasRelatedWork W2356838307 @default.
- W2123231730 hasRelatedWork W236591618 @default.
- W2123231730 hasRelatedWork W2366785048 @default.
- W2123231730 hasRelatedWork W2367106935 @default.
- W2123231730 hasRelatedWork W2374372840 @default.
- W2123231730 hasRelatedWork W2392721562 @default.
- W2123231730 hasRelatedWork W3029039913 @default.
- W2123231730 hasRelatedWork W3031482208 @default.
- W2123231730 hasVolume "32" @default.
- W2123231730 isParatext "false" @default.
- W2123231730 isRetracted "false" @default.
- W2123231730 magId "2123231730" @default.
- W2123231730 workType "article" @default.