FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123233680> ?p ?o ?g. }

• W2123233680 endingPage "793" @default.
• W2123233680 startingPage "793" @default.
• W2123233680 abstract "Benzodiazepine drugs are highly effective anxiolytic medications, but the role of the benzodiazepine-gamma-aminobutyric acid(A)-chloride ion channel macromolecular complex in the pathophysiologic mechanism of anxiety is not well understood. Previous human imaging studies have indicated involvement of specific regions of the brain in anxiety disorders, especially the frontal-prefrontal, temporal, and cingulate cortical and the limbic areas.To identify potential abnormalities of brain benzodiazepine receptor binding number and distribution in anxiety disorders.At the University of Michigan positron emission tomography facility, 11 individuals with DSM-IV-defined anxiety syndrome panic disorder were compared with 21 unaffected healthy control subjects. Design and Main Outcome Measure In a between-group comparison, we used positron emission tomography and the benzodiazepine receptor ligand flumazenil labeled with carbon 11 to assess the regional brain pattern of receptor binding.We observed decreased binding specifically in the insular cortex bilaterally. No binding abnormality was observed in any other brain region, and there was no evidence of abnormal cerebral blood flow anywhere in the brain. Individuals with panic disorder and comorbid depression, indicative of a more severe disorder, had the lowest binding. No significant correlations were observed for binding with age, sex, or duration of disorder.A previous smaller study with the same ligand reported a probable binding abnormality in the right insula. Because gamma-aminobutyric acid is a major inhibitory neurotransmitter in the brain and because benzodiazepines facilitate this effect of gamma-aminobutyric acid, decreased benzodiazepine binding is consistent with localized brain activation (ie, loss of inhibition). Because the insula is strongly involved in visceral-somatic afferent and efferent function, activation of the insula is consistent with the occurrence of the physical symptoms prominently associated with panic disorder." @default.
• W2123233680 created "2016-06-24" @default.
• W2123233680 creator A5007318813 @default.
• W2123233680 creator A5017802159 @default.
• W2123233680 creator A5053750375 @default.
• W2123233680 creator A5056220502 @default.
• W2123233680 creator A5056453682 @default.
• W2123233680 creator A5075089696 @default.
• W2123233680 creator A5083886913 @default.
• W2123233680 date "2007-07-01" @default.
• W2123233680 modified "2023-09-25" @default.
• W2123233680 title "Reduced γ-Aminobutyric AcidA–Benzodiazepine Binding Sites in Insular Cortex of Individuals With Panic Disorder" @default.
• W2123233680 cites W105299122 @default.
• W2123233680 cites W1513763202 @default.
• W2123233680 cites W1593167368 @default.
• W2123233680 cites W1790365870 @default.
• W2123233680 cites W1963592163 @default.
• W2123233680 cites W1968979503 @default.
• W2123233680 cites W1973910022 @default.
• W2123233680 cites W1974235453 @default.
• W2123233680 cites W1976658908 @default.
• W2123233680 cites W1976954310 @default.
• W2123233680 cites W1979153562 @default.
• W2123233680 cites W1982549916 @default.
• W2123233680 cites W1984577458 @default.
• W2123233680 cites W1988308733 @default.
• W2123233680 cites W1999680640 @default.
• W2123233680 cites W2004030076 @default.
• W2123233680 cites W2011251830 @default.
• W2123233680 cites W2022014788 @default.
• W2123233680 cites W2024379900 @default.
• W2123233680 cites W2025083501 @default.
• W2123233680 cites W2025234406 @default.
• W2123233680 cites W2025429574 @default.
• W2123233680 cites W2032610103 @default.
• W2123233680 cites W2033967523 @default.
• W2123233680 cites W2038108778 @default.
• W2123233680 cites W2044420664 @default.
• W2123233680 cites W2048776222 @default.
• W2123233680 cites W2056441561 @default.
• W2123233680 cites W2060056442 @default.
• W2123233680 cites W2065228751 @default.
• W2123233680 cites W2071722127 @default.
• W2123233680 cites W2076532454 @default.
• W2123233680 cites W2081240745 @default.
• W2123233680 cites W2081335111 @default.
• W2123233680 cites W2087519774 @default.
• W2123233680 cites W2088143216 @default.
• W2123233680 cites W2093837465 @default.
• W2123233680 cites W2095173157 @default.
• W2123233680 cites W2102308750 @default.
• W2123233680 cites W2105255193 @default.
• W2123233680 cites W2106588887 @default.
• W2123233680 cites W2111416664 @default.
• W2123233680 cites W2114634718 @default.
• W2123233680 cites W2114770633 @default.
• W2123233680 cites W2116649573 @default.
• W2123233680 cites W2121237571 @default.
• W2123233680 cites W2123369498 @default.
• W2123233680 cites W2124635004 @default.
• W2123233680 cites W2128409098 @default.
• W2123233680 cites W2138790588 @default.
• W2123233680 cites W2139378518 @default.
• W2123233680 cites W2140712651 @default.
• W2123233680 cites W2141984822 @default.
• W2123233680 cites W2159241035 @default.
• W2123233680 cites W2162770913 @default.
• W2123233680 cites W2167979686 @default.
• W2123233680 cites W2169230464 @default.
• W2123233680 cites W2320439911 @default.
• W2123233680 cites W2328057791 @default.
• W2123233680 cites W2408178362 @default.
• W2123233680 cites W2460395268 @default.
• W2123233680 cites W3127623214 @default.
• W2123233680 cites W589533216 @default.
• W2123233680 doi "https://doi.org/10.1001/archpsyc.64.7.793" @default.
• W2123233680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17606813" @default.
• W2123233680 hasPublicationYear "2007" @default.
• W2123233680 type Work @default.
• W2123233680 sameAs 2123233680 @default.
• W2123233680 citedByCount "81" @default.
• W2123233680 countsByYear W21232336802012 @default.
• W2123233680 countsByYear W21232336802013 @default.
• W2123233680 countsByYear W21232336802014 @default.
• W2123233680 countsByYear W21232336802015 @default.
• W2123233680 countsByYear W21232336802016 @default.
• W2123233680 countsByYear W21232336802017 @default.
• W2123233680 countsByYear W21232336802018 @default.
• W2123233680 countsByYear W21232336802019 @default.
• W2123233680 countsByYear W21232336802020 @default.
• W2123233680 countsByYear W21232336802021 @default.
• W2123233680 countsByYear W21232336802022 @default.
• W2123233680 countsByYear W21232336802023 @default.
• W2123233680 crossrefType "journal-article" @default.
• W2123233680 hasAuthorship W2123233680A5007318813 @default.
• W2123233680 hasAuthorship W2123233680A5017802159 @default.
• W2123233680 hasAuthorship W2123233680A5053750375 @default.
• W2123233680 hasAuthorship W2123233680A5056220502 @default.

• next