FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123235021> ?p ?o ?g. }

• W2123235021 endingPage "e000179" @default.
• W2123235021 startingPage "e000179" @default.
• W2123235021 abstract "<h3>Objective</h3> Tumour budding formed by histologically undifferentiated cancer cells beyond the border of the tumour margin is associated with lymph node metastasis. However, hollow tumour nests, a possible histologically advanced phenotype of tumour budding, have not been discussed. We examined whether hollow spheroids exist beyond the border of the invasive margin and are associated with metastasis and prognosis. Moreover, we suggest that carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) isoform balance is associated with hollow spheroid formation. <h3>Methods</h3> Immunohistochemical analyses with CEACAM1 and M30 as an apoptosis marker were performed to examine the importance of hollow spheroid CEACAM1 expression and central cell apoptosis in hollow spheroid formation. The correlations between the presence of hollow spheroids beyond the invasive margin and the clinicopathological characteristics of 314 patients with colorectal cancer were retrospectively evaluated. A 3D culture with colorectal cancer cells transfected with CEACAM1 cDNA or shRNA was used to determine whether CEACAM1 isoform balance controls colorectal hollow spheroid formation. <h3>Results</h3> Hollow spheroid formation accompanying central cell apoptosis was confirmed by M30 staining and serial section with CEACAM1 staining. Of the 314 patients, 96 (30.4%) were classified as having hollow spheroids. The presence of hollow spheroids is an independent risk factor for metastases and shorter survival. In 3D culture, CEACAM1 isoform balance modulated hollow spheroid formation of colorectal cancer cells. <h3>Conclusions</h3> Hollow spheroid formation beyond the border of the tumour margin in colorectal cancer is more important than tumour budding for the prediction of malignant potential." @default.
• W2123235021 created "2016-06-24" @default.
• W2123235021 creator A5004211331 @default.
• W2123235021 creator A5004391555 @default.
• W2123235021 creator A5005616066 @default.
• W2123235021 creator A5011209329 @default.
• W2123235021 creator A5016834515 @default.
• W2123235021 creator A5029064405 @default.
• W2123235021 creator A5033890333 @default.
• W2123235021 creator A5050600975 @default.
• W2123235021 creator A5056726382 @default.
• W2123235021 creator A5057450881 @default.
• W2123235021 creator A5068027322 @default.
• W2123235021 creator A5073275097 @default.
• W2123235021 creator A5086210627 @default.
• W2123235021 creator A5090148802 @default.
• W2123235021 date "2011-08-11" @default.
• W2123235021 modified "2023-09-26" @default.
• W2123235021 title "Hollow spheroids beyond the invasive margin indicate the malignant potential of colorectal cancer" @default.
• W2123235021 cites W1573511653 @default.
• W2123235021 cites W1631351130 @default.
• W2123235021 cites W182194735 @default.
• W2123235021 cites W1968621691 @default.
• W2123235021 cites W1983462117 @default.
• W2123235021 cites W1983532504 @default.
• W2123235021 cites W1984645684 @default.
• W2123235021 cites W1989148960 @default.
• W2123235021 cites W1995036338 @default.
• W2123235021 cites W1996654465 @default.
• W2123235021 cites W2005230990 @default.
• W2123235021 cites W2010066826 @default.
• W2123235021 cites W2017514049 @default.
• W2123235021 cites W2021751282 @default.
• W2123235021 cites W2022487668 @default.
• W2123235021 cites W2029231546 @default.
• W2123235021 cites W2045694484 @default.
• W2123235021 cites W2049179639 @default.
• W2123235021 cites W2051055358 @default.
• W2123235021 cites W2051993489 @default.
• W2123235021 cites W2053190811 @default.
• W2123235021 cites W2054037411 @default.
• W2123235021 cites W2054466868 @default.
• W2123235021 cites W2058245162 @default.
• W2123235021 cites W2073708753 @default.
• W2123235021 cites W2074437332 @default.
• W2123235021 cites W2082857199 @default.
• W2123235021 cites W2083998563 @default.
• W2123235021 cites W2089559330 @default.
• W2123235021 cites W2102986711 @default.
• W2123235021 cites W2106476262 @default.
• W2123235021 cites W2110260685 @default.
• W2123235021 cites W2117159579 @default.
• W2123235021 cites W2136156049 @default.
• W2123235021 cites W2149417967 @default.
• W2123235021 cites W2150327482 @default.
• W2123235021 cites W2152106804 @default.
• W2123235021 cites W2230489472 @default.
• W2123235021 cites W2273092316 @default.
• W2123235021 cites W2319853571 @default.
• W2123235021 cites W2399948064 @default.
• W2123235021 doi "https://doi.org/10.1136/bmjopen-2011-000179" @default.
• W2123235021 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3191579" @default.
• W2123235021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22021784" @default.
• W2123235021 hasPublicationYear "2011" @default.
• W2123235021 type Work @default.
• W2123235021 sameAs 2123235021 @default.
• W2123235021 citedByCount "13" @default.
• W2123235021 countsByYear W21232350212012 @default.
• W2123235021 countsByYear W21232350212013 @default.
• W2123235021 countsByYear W21232350212014 @default.
• W2123235021 countsByYear W21232350212015 @default.
• W2123235021 countsByYear W21232350212017 @default.
• W2123235021 countsByYear W21232350212019 @default.
• W2123235021 countsByYear W21232350212020 @default.
• W2123235021 countsByYear W21232350212023 @default.
• W2123235021 crossrefType "journal-article" @default.
• W2123235021 hasAuthorship W2123235021A5004211331 @default.
• W2123235021 hasAuthorship W2123235021A5004391555 @default.
• W2123235021 hasAuthorship W2123235021A5005616066 @default.
• W2123235021 hasAuthorship W2123235021A5011209329 @default.
• W2123235021 hasAuthorship W2123235021A5016834515 @default.
• W2123235021 hasAuthorship W2123235021A5029064405 @default.
• W2123235021 hasAuthorship W2123235021A5033890333 @default.
• W2123235021 hasAuthorship W2123235021A5050600975 @default.
• W2123235021 hasAuthorship W2123235021A5056726382 @default.
• W2123235021 hasAuthorship W2123235021A5057450881 @default.
• W2123235021 hasAuthorship W2123235021A5068027322 @default.
• W2123235021 hasAuthorship W2123235021A5073275097 @default.
• W2123235021 hasAuthorship W2123235021A5086210627 @default.
• W2123235021 hasAuthorship W2123235021A5090148802 @default.
• W2123235021 hasBestOaLocation W21232350211 @default.
• W2123235021 hasConcept C121608353 @default.
• W2123235021 hasConcept C126322002 @default.
• W2123235021 hasConcept C142724271 @default.
• W2123235021 hasConcept C175369904 @default.
• W2123235021 hasConcept C190283241 @default.
• W2123235021 hasConcept C204232928 @default.
• W2123235021 hasConcept C2777387746 @default.

• next