Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123236557> ?p ?o ?g. }
- W2123236557 endingPage "e37311" @default.
- W2123236557 startingPage "e37311" @default.
- W2123236557 abstract "IL-12 and IL-23 regulate innate and adaptive immunity to microbial pathogens through influencing the expression of IFN-γ, IL-17, and IL-22. Herein we define the roles of IL-12 and IL-23 in regulating host resistance and intestinal inflammation during acute Salmonella infection. We find that IL-23 alone is dispensable for protection against systemic spread of bacteria, but synergizes with IL-12 for optimal protection. IL-12 promotes the production of IFN-γ by NK cells, which is required for resistance against Salmonella and also for induction of intestinal inflammation and epithelial injury. In contrast, IL-23 controls the severity of inflammation by inhibiting IL-12A expression, reducing IFN-γ and preventing excessive mucosal injury. Our studies demonstrate that IL-23 is a homeostatic regulator of IL-12-dependent, IFN-γ-mediated intestinal inflammation." @default.
- W2123236557 created "2016-06-24" @default.
- W2123236557 creator A5027246219 @default.
- W2123236557 creator A5028473222 @default.
- W2123236557 creator A5065207317 @default.
- W2123236557 creator A5067623106 @default.
- W2123236557 creator A5079322424 @default.
- W2123236557 date "2012-05-18" @default.
- W2123236557 modified "2023-09-26" @default.
- W2123236557 title "Homeostatic Regulation of Salmonella-Induced Mucosal Inflammation and Injury by IL-23" @default.
- W2123236557 cites W1535831265 @default.
- W2123236557 cites W1551727579 @default.
- W2123236557 cites W1553227656 @default.
- W2123236557 cites W1585477246 @default.
- W2123236557 cites W1768580582 @default.
- W2123236557 cites W1892690144 @default.
- W2123236557 cites W1905324622 @default.
- W2123236557 cites W1982840915 @default.
- W2123236557 cites W1986660413 @default.
- W2123236557 cites W1990083653 @default.
- W2123236557 cites W2002148098 @default.
- W2123236557 cites W2010506461 @default.
- W2123236557 cites W2010847298 @default.
- W2123236557 cites W2016850513 @default.
- W2123236557 cites W2020233428 @default.
- W2123236557 cites W2031352506 @default.
- W2123236557 cites W2033507649 @default.
- W2123236557 cites W2033529357 @default.
- W2123236557 cites W2035031252 @default.
- W2123236557 cites W2040702442 @default.
- W2123236557 cites W2042048278 @default.
- W2123236557 cites W2050849048 @default.
- W2123236557 cites W2051281891 @default.
- W2123236557 cites W2069571875 @default.
- W2123236557 cites W2087905758 @default.
- W2123236557 cites W2091378964 @default.
- W2123236557 cites W2092719112 @default.
- W2123236557 cites W2095655760 @default.
- W2123236557 cites W2106464597 @default.
- W2123236557 cites W2106604753 @default.
- W2123236557 cites W2106860933 @default.
- W2123236557 cites W2107066107 @default.
- W2123236557 cites W2110033222 @default.
- W2123236557 cites W2112128505 @default.
- W2123236557 cites W2112475646 @default.
- W2123236557 cites W2116899741 @default.
- W2123236557 cites W2122723986 @default.
- W2123236557 cites W2124519481 @default.
- W2123236557 cites W2130959939 @default.
- W2123236557 cites W2133435354 @default.
- W2123236557 cites W2146153364 @default.
- W2123236557 cites W2151925533 @default.
- W2123236557 cites W2154218327 @default.
- W2123236557 cites W2154676602 @default.
- W2123236557 cites W2158002180 @default.
- W2123236557 doi "https://doi.org/10.1371/journal.pone.0037311" @default.
- W2123236557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3356277" @default.
- W2123236557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22624013" @default.
- W2123236557 hasPublicationYear "2012" @default.
- W2123236557 type Work @default.
- W2123236557 sameAs 2123236557 @default.
- W2123236557 citedByCount "18" @default.
- W2123236557 countsByYear W21232365572013 @default.
- W2123236557 countsByYear W21232365572014 @default.
- W2123236557 countsByYear W21232365572015 @default.
- W2123236557 countsByYear W21232365572017 @default.
- W2123236557 countsByYear W21232365572018 @default.
- W2123236557 countsByYear W21232365572019 @default.
- W2123236557 countsByYear W21232365572020 @default.
- W2123236557 countsByYear W21232365572021 @default.
- W2123236557 crossrefType "journal-article" @default.
- W2123236557 hasAuthorship W2123236557A5027246219 @default.
- W2123236557 hasAuthorship W2123236557A5028473222 @default.
- W2123236557 hasAuthorship W2123236557A5065207317 @default.
- W2123236557 hasAuthorship W2123236557A5067623106 @default.
- W2123236557 hasAuthorship W2123236557A5079322424 @default.
- W2123236557 hasBestOaLocation W21232365571 @default.
- W2123236557 hasConcept C126322002 @default.
- W2123236557 hasConcept C136449434 @default.
- W2123236557 hasConcept C156730664 @default.
- W2123236557 hasConcept C187316574 @default.
- W2123236557 hasConcept C193419808 @default.
- W2123236557 hasConcept C203014093 @default.
- W2123236557 hasConcept C2776914184 @default.
- W2123236557 hasConcept C2778782520 @default.
- W2123236557 hasConcept C2779341262 @default.
- W2123236557 hasConcept C2781065037 @default.
- W2123236557 hasConcept C3019368612 @default.
- W2123236557 hasConcept C47348012 @default.
- W2123236557 hasConcept C523546767 @default.
- W2123236557 hasConcept C54355233 @default.
- W2123236557 hasConcept C63645605 @default.
- W2123236557 hasConcept C71924100 @default.
- W2123236557 hasConcept C86803240 @default.
- W2123236557 hasConcept C8891405 @default.
- W2123236557 hasConcept C89423630 @default.
- W2123236557 hasConcept C95444343 @default.
- W2123236557 hasConceptScore W2123236557C126322002 @default.