FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123239600> ?p ?o ?g. }

• W2123239600 endingPage "612" @default.
• W2123239600 startingPage "604" @default.
• W2123239600 abstract "Coordinated migration and progesterone production by granulosa cells is critical to the development of the corpus luteum, but the underlying mechanisms remain obscure. Sphingosine 1-phosphate (S1P), which is associated with follicular fluid high-density lipoprotein (FF-HDL), was previously shown to regulate ovarian angiogenesis. We herein examined the effects of S1P and FF-HDL on the function of granulosa lutein cells. Both FF-HDL and S1P induced migration of primary human granulosa lutein cells (hGCs) and the granulosa lutein cell line HGL5. In addition, FF-HDL but not S1P promoted progesterone synthesis, and neither of the two compounds stimulated proliferation of granulosa lutein cells. Polymerase chain reaction and Western blot experiments demonstrated the expression of S1P receptor type 1 (S1PR1), S1PR2, S1PR3, and S1PR5 but not S1PR4 in hGCs and HGL5 cells. The FF-HDL- and S1P-induced granulosa lutein cell migration was emulated by FTY720, an agonist of S1PR1, S1PR3, S1PR4, and S1PR5, and by VPC24191, an agonist of S1PR1 and S1PR3, but not by SEW2871 and phytosphingosine 1-phosphate, agonists of S1PR1 and S1PR4, respectively. In addition, blockade of S1PR3 with CAY1044, suramine, or pertussis toxin inhibited hGC and HGL5 cell migration toward FF-HDL or S1P, while blockade of S1PR1 and S1PR2 with W146 and JTE013, respectively, had no effect. Both FF-HDL and S1P triggered activation of small G-protein RAC1 and actin polymerization in granulosa cells, and RAC1 inhibition with Clostridium difficile toxin B or NSC23766 abolished FF-HDL- and S1P-induced migration. The FF-HDL-associated S1P promotes granulosa lutein cell migration via S1PR3 and RAC1 activation. This may represent a novel mechanism contributing to the development of the corpus luteum." @default.
• W2123239600 created "2016-06-24" @default.
• W2123239600 creator A5006492057 @default.
• W2123239600 creator A5030096952 @default.
• W2123239600 creator A5035295431 @default.
• W2123239600 creator A5048059512 @default.
• W2123239600 creator A5056936867 @default.
• W2123239600 date "2011-03-01" @default.
• W2123239600 modified "2023-10-17" @default.
• W2123239600 title "Follicular Fluid High-Density Lipoprotein-Associated Sphingosine 1-Phosphate (S1P) Promotes Human Granulosa Lutein Cell Migration via S1P Receptor Type 3 and Small G-Protein RAC11" @default.
• W2123239600 cites W1570743730 @default.
• W2123239600 cites W1597787921 @default.
• W2123239600 cites W1775749144 @default.
• W2123239600 cites W184854032 @default.
• W2123239600 cites W1960843983 @default.
• W2123239600 cites W1967642852 @default.
• W2123239600 cites W1968306248 @default.
• W2123239600 cites W1970717080 @default.
• W2123239600 cites W1978313960 @default.
• W2123239600 cites W1979990604 @default.
• W2123239600 cites W1980084524 @default.
• W2123239600 cites W1980553725 @default.
• W2123239600 cites W1981932258 @default.
• W2123239600 cites W1984290711 @default.
• W2123239600 cites W1991324453 @default.
• W2123239600 cites W1991558659 @default.
• W2123239600 cites W1991624475 @default.
• W2123239600 cites W1994791673 @default.
• W2123239600 cites W1996180854 @default.
• W2123239600 cites W2009950379 @default.
• W2123239600 cites W2010205740 @default.
• W2123239600 cites W2019731805 @default.
• W2123239600 cites W2019889454 @default.
• W2123239600 cites W2037831313 @default.
• W2123239600 cites W2047174762 @default.
• W2123239600 cites W2052488903 @default.
• W2123239600 cites W2053556262 @default.
• W2123239600 cites W2065543350 @default.
• W2123239600 cites W2066565536 @default.
• W2123239600 cites W2072338652 @default.
• W2123239600 cites W2078845055 @default.
• W2123239600 cites W2081529705 @default.
• W2123239600 cites W2082032805 @default.
• W2123239600 cites W2088161473 @default.
• W2123239600 cites W2093914571 @default.
• W2123239600 cites W2103753682 @default.
• W2123239600 cites W2107141026 @default.
• W2123239600 cites W2108626995 @default.
• W2123239600 cites W2118861337 @default.
• W2123239600 cites W2119802141 @default.
• W2123239600 cites W2123915935 @default.
• W2123239600 cites W2127032203 @default.
• W2123239600 cites W2130392812 @default.
• W2123239600 cites W2142685635 @default.
• W2123239600 cites W2144885443 @default.
• W2123239600 cites W2147432416 @default.
• W2123239600 cites W2154113347 @default.
• W2123239600 cites W2159131465 @default.
• W2123239600 cites W2168344795 @default.
• W2123239600 cites W2169616751 @default.
• W2123239600 cites W2171175765 @default.
• W2123239600 cites W2402712445 @default.
• W2123239600 cites W2070893206 @default.
• W2123239600 doi "https://doi.org/10.1095/biolreprod.110.084152" @default.
• W2123239600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20980685" @default.
• W2123239600 hasPublicationYear "2011" @default.
• W2123239600 type Work @default.
• W2123239600 sameAs 2123239600 @default.
• W2123239600 citedByCount "32" @default.
• W2123239600 countsByYear W21232396002012 @default.
• W2123239600 countsByYear W21232396002013 @default.
• W2123239600 countsByYear W21232396002014 @default.
• W2123239600 countsByYear W21232396002015 @default.
• W2123239600 countsByYear W21232396002016 @default.
• W2123239600 countsByYear W21232396002017 @default.
• W2123239600 countsByYear W21232396002018 @default.
• W2123239600 countsByYear W21232396002019 @default.
• W2123239600 countsByYear W21232396002020 @default.
• W2123239600 countsByYear W21232396002021 @default.
• W2123239600 countsByYear W21232396002022 @default.
• W2123239600 countsByYear W21232396002023 @default.
• W2123239600 crossrefType "journal-article" @default.
• W2123239600 hasAuthorship W2123239600A5006492057 @default.
• W2123239600 hasAuthorship W2123239600A5030096952 @default.
• W2123239600 hasAuthorship W2123239600A5035295431 @default.
• W2123239600 hasAuthorship W2123239600A5048059512 @default.
• W2123239600 hasAuthorship W2123239600A5056936867 @default.
• W2123239600 hasConcept C126322002 @default.
• W2123239600 hasConcept C134018914 @default.
• W2123239600 hasConcept C140800825 @default.
• W2123239600 hasConcept C146285616 @default.
• W2123239600 hasConcept C167734588 @default.
• W2123239600 hasConcept C170493617 @default.
• W2123239600 hasConcept C187785154 @default.
• W2123239600 hasConcept C2776596873 @default.
• W2123239600 hasConcept C2776608385 @default.
• W2123239600 hasConcept C2777025900 @default.
• W2123239600 hasConcept C2777203538 @default.

• next