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- W2123240057 abstract "Nine reversely C3-prenylated pyrrolo[2,3-b]indoles were successfully prepared by using two recombinant enzymes involved in the biosynthesis of acetylaszonalenin from Neosartorya fischeri. The prenyltransferase AnaPT catalysed the conversion of six tryptophan-containing cyclic dipeptides to reversely C3-prenylated indoline derivatives. Using cyclo-L-Trp-L-Trp as substrate, both mono- and diprenylated indolines were obtained. Two of the AnaPT products were acetylated at position N1 by the acetyltransferase AnaAT. The structures of the obtained compounds were characterised by HR-ESI-MS, 1H- and 13C-NMR analyses as well as by long-range 1H-13C connectivities in heteronuclear multiple-bond correlation (HMBC) spectra after preparative isolation. Their absolute configurations were determined by analysing the 1H-1H spatial correlations in rotating-frame nuclear overhauser effect spectroscopy (ROESY)." @default.
- W2123240057 created "2016-06-24" @default.
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- W2123240057 date "2010-01-01" @default.
- W2123240057 modified "2023-09-25" @default.
- W2123240057 title "Reconstruction of pyrrolo[2,3-b]indoles carrying an α-configured reverse C3-dimethylallyl moiety by using recombinant enzymes" @default.
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- W2123240057 doi "https://doi.org/10.1039/b922440h" @default.
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