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- W2123247102 abstract "Signalling pathways are well-known abstractions that explain the mechanisms whereby cells respond to signals. Collections of pathways form networks, and interactions between pathways in a network, known as cross-talk, enables further complex signalling behaviours. While there are several formal modelling approaches for signalling pathways, none make cross-talk explicit; the aim of this paper is to define and categorise cross-talk in a rigorous way. We define a modular approach to pathway and network modelling, based on the module construct in the PRISM modelling language, and a set of generic signalling modules. Five different types of cross-talk are defined according to various biologically meaningful combinations of variable sharing, synchronisation labels and reaction renaming. The approach is illustrated with a case-study analysis of cross-talk between the TGF- β , WNT and MAPK pathways." @default.
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- W2123247102 date "2012-10-01" @default.
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- W2123247102 title "Modular modelling of signalling pathways and their cross-talk" @default.
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- W2123247102 doi "https://doi.org/10.1016/j.tcs.2012.07.003" @default.
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