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- W2123248911 abstract "In tonsils, CD138+ plasma cells (PCs) are surrounded by CD163+ resident macrophages (Mϕs). We show here that human Mϕs (isolated from tonsils or generated from monocytes in vitro) drive activated B cells to differentiate into CD138+CD38++ PCs through secreted CXCL10/IP-10 and VCAM-1 contact. IP-10 production by Mϕs is induced by B cell–derived IL-6 and depends on STAT3 phosphorylation. Furthermore, IP-10 amplifies the production of IL-6 by B cells, which sustains the STAT3 signals that lead to PC differentiation. IP-10–deficient mice challenged with NP-Ficoll show a decreased frequency of NP-specific PCs and lower titers of antibodies. Thus, our results reveal a novel dialog between Mϕs and B cells, in which IP-10 acts as a PC differentiation factor." @default.
- W2123248911 created "2016-06-24" @default.
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- W2123248911 date "2012-09-17" @default.
- W2123248911 modified "2023-10-17" @default.
- W2123248911 title "Macrophages induce differentiation of plasma cells through CXCL10/IP-10" @default.
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- W2123248911 doi "https://doi.org/10.1084/jem.20112142" @default.
- W2123248911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3457728" @default.
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