Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123262178> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2123262178 endingPage "191" @default.
- W2123262178 startingPage "186" @default.
- W2123262178 abstract "Tumor suppressor proteins must be exquisitely regulated since they can induce cell death while preventing cancer. For example, the p19ARF tumor suppressor (p14ARF in humans) appears to stimulate the apoptotic function of the p53 tumor suppressor to prevent lymphomagenesis and carcinogenesis induced by oncogene overexpression. Here we present a genetic approach to defining the role of p19ARF in regulating the apoptotic function of p53 in highly proliferating, homeostatic tissues. In contrast to our expectation, p19ARF did not activate the apoptotic function of p53 in lymphocytes or epithelial cells. These results demonstrate that the mechanisms that control p53 function during homeostasis differ from those that are critical for tumor suppression. Moreover, the Mdm2/p53/p19ARF pathway appears to exist only under very restricted conditions." @default.
- W2123262178 created "2016-06-24" @default.
- W2123262178 creator A5024598807 @default.
- W2123262178 creator A5039907102 @default.
- W2123262178 creator A5042517317 @default.
- W2123262178 creator A5056790767 @default.
- W2123262178 date "2004-01-01" @default.
- W2123262178 modified "2023-09-26" @default.
- W2123262178 title "Mdm2 Regulates p53 Independently of p19<sup>ARF</sup> in Homeostatic Tissues" @default.
- W2123262178 cites W1969044026 @default.
- W2123262178 cites W1973886069 @default.
- W2123262178 cites W1983751803 @default.
- W2123262178 cites W1983822300 @default.
- W2123262178 cites W1986763150 @default.
- W2123262178 cites W1993864973 @default.
- W2123262178 cites W2035277612 @default.
- W2123262178 cites W2046958356 @default.
- W2123262178 cites W2079413263 @default.
- W2123262178 cites W2090930894 @default.
- W2123262178 cites W2101801927 @default.
- W2123262178 cites W2102930268 @default.
- W2123262178 cites W2103756564 @default.
- W2123262178 cites W2117736191 @default.
- W2123262178 cites W2126679757 @default.
- W2123262178 cites W2130555878 @default.
- W2123262178 cites W2136422121 @default.
- W2123262178 cites W2150608281 @default.
- W2123262178 cites W2164559478 @default.
- W2123262178 cites W2330712443 @default.
- W2123262178 doi "https://doi.org/10.1128/mcb.24.1.186-191.2004" @default.
- W2123262178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/303350" @default.
- W2123262178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14673154" @default.
- W2123262178 hasPublicationYear "2004" @default.
- W2123262178 type Work @default.
- W2123262178 sameAs 2123262178 @default.
- W2123262178 citedByCount "25" @default.
- W2123262178 countsByYear W21232621782012 @default.
- W2123262178 countsByYear W21232621782014 @default.
- W2123262178 countsByYear W21232621782021 @default.
- W2123262178 countsByYear W21232621782022 @default.
- W2123262178 crossrefType "journal-article" @default.
- W2123262178 hasAuthorship W2123262178A5024598807 @default.
- W2123262178 hasAuthorship W2123262178A5039907102 @default.
- W2123262178 hasAuthorship W2123262178A5042517317 @default.
- W2123262178 hasAuthorship W2123262178A5056790767 @default.
- W2123262178 hasBestOaLocation W21232621782 @default.
- W2123262178 hasConcept C121608353 @default.
- W2123262178 hasConcept C14036430 @default.
- W2123262178 hasConcept C179185449 @default.
- W2123262178 hasConcept C190283241 @default.
- W2123262178 hasConcept C2776192174 @default.
- W2123262178 hasConcept C2776750431 @default.
- W2123262178 hasConcept C2778264664 @default.
- W2123262178 hasConcept C2781018059 @default.
- W2123262178 hasConcept C29537977 @default.
- W2123262178 hasConcept C502942594 @default.
- W2123262178 hasConcept C54355233 @default.
- W2123262178 hasConcept C555283112 @default.
- W2123262178 hasConcept C63645605 @default.
- W2123262178 hasConcept C86803240 @default.
- W2123262178 hasConcept C95444343 @default.
- W2123262178 hasConceptScore W2123262178C121608353 @default.
- W2123262178 hasConceptScore W2123262178C14036430 @default.
- W2123262178 hasConceptScore W2123262178C179185449 @default.
- W2123262178 hasConceptScore W2123262178C190283241 @default.
- W2123262178 hasConceptScore W2123262178C2776192174 @default.
- W2123262178 hasConceptScore W2123262178C2776750431 @default.
- W2123262178 hasConceptScore W2123262178C2778264664 @default.
- W2123262178 hasConceptScore W2123262178C2781018059 @default.
- W2123262178 hasConceptScore W2123262178C29537977 @default.
- W2123262178 hasConceptScore W2123262178C502942594 @default.
- W2123262178 hasConceptScore W2123262178C54355233 @default.
- W2123262178 hasConceptScore W2123262178C555283112 @default.
- W2123262178 hasConceptScore W2123262178C63645605 @default.
- W2123262178 hasConceptScore W2123262178C86803240 @default.
- W2123262178 hasConceptScore W2123262178C95444343 @default.
- W2123262178 hasIssue "1" @default.
- W2123262178 hasLocation W21232621781 @default.
- W2123262178 hasLocation W21232621782 @default.
- W2123262178 hasLocation W21232621783 @default.
- W2123262178 hasOpenAccess W2123262178 @default.
- W2123262178 hasPrimaryLocation W21232621781 @default.
- W2123262178 hasRelatedWork W1532697565 @default.
- W2123262178 hasRelatedWork W1988593536 @default.
- W2123262178 hasRelatedWork W2072594716 @default.
- W2123262178 hasRelatedWork W2106048601 @default.
- W2123262178 hasRelatedWork W2124832202 @default.
- W2123262178 hasRelatedWork W2142432694 @default.
- W2123262178 hasRelatedWork W2224899546 @default.
- W2123262178 hasRelatedWork W2367539210 @default.
- W2123262178 hasRelatedWork W2898164255 @default.
- W2123262178 hasRelatedWork W3094652082 @default.
- W2123262178 hasVolume "24" @default.
- W2123262178 isParatext "false" @default.
- W2123262178 isRetracted "false" @default.
- W2123262178 magId "2123262178" @default.
- W2123262178 workType "article" @default.